| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Thoracic and Cardiovascular Surgery, Vol 100, 777-780, Copyright © 1990 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
L Nilsson, L Kulander, SO Nystrom and O Eriksson
Endotoxins are biologically active substances derived from the cell wall of
degraded gram-negative bacteria. Since sterile water may also contain large
amounts of endotoxins, these are easily introduced into the manufacturing
processes of technical medical material, such as the extracorporeal
components used in cardiopulmonary bypass. In hemodialysis, the presence of
endotoxins has been related to untoward effects in patients. Using the
limulus amebocyte lysate test, we determined the serum concentration of
endotoxin in 42 patients undergoing coronary bypass operations. The values
increased during cardiopulmonary bypass, exceeding the normal range of 0 to
20 ng/L in 10 patients with a maximum of 82 ng/L, which probably indicates
endotoxin release from the extracorporeal equipment. We found no obvious
relation to postoperative morbidity. The endotoxin levels of this study are
considerably lower than those reported in two other studies of patients
having cardiopulmonary bypass. This might be due to less intraoperative
contamination but possibly also to differences in analytic methods.
ARTICLES
Endotoxins in cardiopulmonary bypass
Department of Thoracic Surgery, University Hospital, Uppsala, Sweden.
This article has been cited by other articles:
|
|
 |
|
  S. Kats, J. P. A. M. Schonberger, R. Brands, W. Seinen, and W. van Oeveren Endotoxin release in cardiac surgery with cardiopulmonary bypass: pathophysiology and possible therapeutic strategies. An update Eur J Cardiothorac Surg, April 1, 2011; 39(4): 451 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Thiara, V. Andersen, V. Videm, T. Mollnes, K. Svennevig, T. Hoel, and A. Fiane Comparable biocompatibility of Phisio- and Bioline-coated cardiopulmonary bypass circuits indicated by the inflammatory response Perfusion, January 1, 2010; 25(1): 9 - 16. [Abstract] [PDF]
|
|
|
|
 |
|
 M. H. Rosner, D. Portilla, and M. D. Okusa Analytic Reviews: Cardiac Surgery as a Cause of Acute Kidney Injury: Pathogenesis and Potential Therapies J Intensive Care Med, January 1, 2008; 23(1): 3 - 18. [Abstract] [PDF]
|
|
|
|
 |
|
 J. W. Hammon Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation Card. Surg. Adult, January 1, 2008; 3(2008): 370 - 389. [Full Text]
|
|
|
|
 |
|
 E. Bennett-Guerrero, H. P. Grocott, J. H. Levy, K. A. Stierer, C. W. Hogue, A. T. Cheung, M. F. Newman, A. A. Carter, D. P. Rossignol, and C. D. Collard A Phase II, Double-Blind, Placebo-Controlled, Ascending-Dose Study of Eritoran (E5564), a Lipid A Antagonist, in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass Anesth. Analg., February 1, 2007; 104(2): 378 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Rosner and M. D. Okusa Acute Kidney Injury Associated with Cardiac Surgery Clin. J. Am. Soc. Nephrol., January 1, 2006; 1(1): 19 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. B. Aydin, H. Gercekoglu, B. Aksu, V. Ozkul, T. Sener, I. Kiygil, T. Turkoglu, S. Cimen, F. Babacan, and M. Demirtas Endotoxemia in coronary artery bypass surgery: A comparison of the off-pump technique and conventional cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., April 1, 2003; 125(4): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]
|
|
|
|
 |
|
 M. P Vallely, P. G Bannon, C. F Hughes, and L. Kritharides Endothelial Cell Adhesion Molecules and Cardiopulmonary Bypass Asian Cardiovasc Thorac Ann, December 1, 2001; 9(4): 349 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Hennein Inflammation After Cardiopulmonary Bypass: Therapy for the Postpump Syndrome Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 236 - 255. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Storck, K. Buttenschoen, D. Berger, A. Hannekum, and E. Boelke Endotoxemia and Mediator Release During Cardiac Surgery Angiology, September 1, 2000; 51(9): 743 - 749. [Abstract] [PDF]
|
|
|
|
|
|
V. Videm, J. L Svennevig, E. Fosse, B. Mohr, and A. O Aasen Plasma endotoxin concentrations during cardiac surgery may be related to atherosclerosis Perfusion, September 1, 2000; 15(5): 421 - 426. [Abstract] [PDF]
|
|
|
|
 |
|
 L. L. Lequier, H. Nikaidoh, S. R. Leonard, J. L. Bokovoy, M. L. White, P. J. Scannon, and B. P. Giroir Preoperative and Postoperative Endotoxemia in Children With Congenital Heart Disease Chest, June 1, 2000; 117(6): 1706 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wan, J.-L. LeClerc, C.-H. Huynh, D. Schmartz, J.-M. DeSmet, A. P.C. Yim, and J.-L. Vincent DOES STEROID PRETREATMENT INCREASE ENDOTOXIN RELEASE DURING CLINICAL CARDIOPULMONARY BYPASS? J. Thorac. Cardiovasc. Surg., May 1, 1999; 117(5): 1004 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Boyle Jr, T. H. Pohlman, M. C. Johnson, and E. D. Verrier Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response Ann. Thorac. Surg., January 1, 1997; 63(1): 277 - 284. [Abstract] [Full Text]
|
|
|
|
|
|
S. Watarida, A. Mori, M. Onoe, R. Tabata, S. Shiraishi, T. Sugita, T. Nojima, Y. Nakajima, and S. Matsuno A clinical study on the effects of pulsatile cardiopulmonary bypass on the blood endotoxin levels J. Thorac. Cardiovasc. Surg., October 1, 1994; 108(4): 620 - 625. [Abstract] [Full Text]
|
|
|
|
|
|
S. K. Ohri, J. Becket, J. Brannan, B. E. Keogh, and K. M. Taylor Effects of cardiopulmonary bypass on gut blood flow, oxygen utilization, and intramucosal pH Ann. Thorac. Surg., May 1, 1994; 57(5): 1193 - 1199. [Abstract] [PDF]
|
|
|
|
|
|
S.K. Ohri, C.T. Bowles, A. Siddiqui, A. Khaghani, B.E. Keogh, G. Wright, M.H. Yacoub, and K.M. Taylor The effect of cardiopulmonary bypass on gastric and colonic mucosal perfusion: a tonometric assessment Perfusion, March 1, 1994; 9(2): 101 - 108. [Abstract] [PDF]
|
|
|
|
|
|
D. P. Taggart, S. Sundaram, C. McCartney, A. Bowman, H. McIntyre, J. M. Courtney, and D. J. Wheatley Endotoxemia, complement, and white blood cell activation in cardiac surgery: A randomized trial of laxatives and pulsatile perfusion Ann. Thorac. Surg., February 1, 1994; 57(2): 376 - 382. [Abstract] [PDF]
|
|
|
|
|
|
J. Butler, G. M. Rocker, and S. Westaby Inflammatory response to cardiopulmonary bypass Ann. Thorac. Surg., February 1, 1993; 55(2): 552 - 559. [Abstract] [PDF]
|
|
|
|
|
|
L. Andersen and L. Baek Transient endotoxaemia during cardiac surgery Perfusion, January 1, 1992; 7(1): 53 - 58. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
