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The Journal of Thoracic and Cardiovascular Surgery, Vol 101, 256-259, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Evolution of human cardiac myocyte dimension during prolonged mechanical support

L Jacquet, T Zerbe, KL Stein, RL Kormos and BP Griffith
Division of Critical Care Medicine, University of Pittsburgh School of Medicine, Pa.

In animal models using left ventricular assist systems over long time periods, myocardial cellular atrophy has been reported, raising concern that prolonged clinical use of such systems might lead to deterioration in left ventricular function. At the University of Pittsburgh, long- term clinical use of the Novacor (Baxter Healthcare Corp., Novacor Div., Oakland, Calif.) left ventricular support system for patients awaiting heart transplants has allowed study of the effects of long- term mechanical support on human subjects. This study determined that cardiac myocyte dimension is initially greater in patients with end- stage cardiac disease who require support rather than in patients with the same disease who do not require such support. Although myocyte dimension does decrease within a few days of the inception of support, this decrease merely brings cell size closer to the values usual in patients with chronic end-stage cardiac disease, and no further shrinkage is observed. Thus the Novacor left ventricular assist system does not appear associated with left ventricular atrophy, and its long- term use may not be detrimental to left ventricular function.

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