HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Patterson, G. A. Articles by Todd, T. R. Search for Related Content PubMed PubMed Citation Articles by Patterson, G. A. Articles by Todd, T. R.

The Journal of Thoracic and Cardiovascular Surgery, Vol 101, 623-631, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Comparison of outcomes of double and single lung transplantation for obstructive lung disease. The Toronto Lung Transplant Group

GA Patterson, JR Maurer, TJ Williams, PG Cardoso, M Scavuzzo and TR Todd
Division of Thoracic Surgery, University of Toronto, Toronto General Hospital, Ontario, Canada.

Single lung transplantation has recently been applied with success in patients with obstructive lung disease. Such patients were previously managed by bilateral pulmonary transplantation. Between November 1986 and January 1990, 18 patients underwent transplantation for obstructive lung disease in our center. Eleven double lung transplants and seven single lung transplants were performed in patients having a mean age of 43.4 and 44.1 years, respectively. Operative death occurred in two of 11 double lung transplantations and one of seven single lung transplantations. Each patient underwent preoperative and 3-month postoperative pulmonary function tests, arterial blood gas analyses, nuclear lung scans, and 6-minute walk tests. There was no difference in the preoperative values for any of these parameters. Double lung recipients had significantly higher forced expiratory volume in 1 second and forced vital capacity than single lung recipients. However, the ratios of forced expiratory volume in 1 second to vital capacity were not different. Arterial oxygen and carbon dioxide tension were not different between the two procedures. Whereas double lung transplantations caused a slight preponderance of perfusion to the right lung, the transplanted lung in single lung recipients received a mean of 79.5% +/- 12.3% of predicted flow and only 61.6% +/- 5.0% of predicted ventilation. Three-month 6-minute walk distances were markedly improved in both groups, with double lung recipients achieving 573.0 +/- 44.7 m in comparison with the 528.0 +/- 43.0 m achieved by the single lung recipients. Single lung transplantation is a satisfactory option in patients with obstructive lung disease and might offer significant advantages to the older patient population, in which risk of double lung transplantation is high.

This article has been cited by other articles:

				W. Weder Lung volume reduction surgery Lung Transplantation, July 1, 2010; 40 - 46. [Abstract] [Fulltext] [PDF]

				S. M. Studer, J. B. Orens, and K. McNeil Long-term management, functional outcome and results Lung Transplantation, July 1, 2010; 179 - 192. [Abstract] [Fulltext] [PDF]

				F. Venuta, A. M. Ciccone, and G. F. Coloni Surgery for emphysema and prospects for the future Surgery for Non-Neoplastic Disorders of the Chest: a Clinical Update, June 28, 2010; 139 - 155. [Abstract] [Fulltext] [PDF]

				D. V. Pilcher, G. M. Auzinger, B. Mitra, D. V. Tuxen, R. F. Salamonsen, A. R. Davies, T. J. Williams, and G. I. Snell Predictors of independent lung ventilation: An analysis of 170 single-lung transplantations J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 1071 - 1077. [Abstract] [Full Text] [PDF]

				M. E. Bowdish, R. Pessotto, R. G. Barbers, F. A. Schenkel, V. A. Starnes, and M. L. Barr Long-term Pulmonary Function After Living-Donor Lobar Lung Transplantation in Adults Ann. Thorac. Surg., February 1, 2005; 79(2): 418 - 425. [Abstract] [Full Text] [PDF]

				S.M. Studer, R.D. Levy, K. McNeil, and J.B. Orens Lung transplant outcomes: a review of survival, graft function, physiology, health-related quality of life and cost-effectiveness Eur. Respir. J., October 1, 2004; 24(4): 674 - 685. [Abstract] [Full Text] [PDF]

				B. R. Celli A 62-Year-Old Woman With Chronic Obstructive Pulmonary Disease JAMA, November 26, 2003; 290(20): 2721 - 2729. [Full Text] [PDF]

				B F Meyers and G A Patterson Chronic obstructive pulmonary disease * 10: Bullectomy, lung volume reduction surgery, and transplantation for patients with chronic obstructive pulmonary disease Thorax, July 1, 2003; 58(7): 634 - 638. [Abstract] [Full Text] [PDF]

				B. F. Meyers, J. P. Lynch, E. P. Trulock, T. Guthrie, J. D. Cooper, and G. A. Patterson Single versus bilateral lung transplantation for idiopathic pulmonary fibrosisA ten-year institutional experience J. Thorac. Cardiovasc. Surg., July 1, 2000; 120(1): 99 - 107. [Abstract] [Full Text] [PDF]

				R. C Cook, G. Fradet, D. Ostrow, and B. Nelems Lung Volume Reduction Surgery Following Single-Lung Transplantation Asian Cardiovasc Thorac Ann, September 1, 1999; 7(3): 221 - 224. [Abstract] [Full Text] [PDF]

				T. R. J. Todd, J. Perron, T. L. Winton, and S. H. Keshavjee Simultaneous Single-Lung Transplantation and Lung Volume Reduction Ann. Thorac. Surg., May 1, 1997; 63(5): 1468 - 1470. [Abstract] [Full Text]

				J. E. Bavaria, R. Kotloff, H. Palevsky, B. Rosengard, J. R. Roberts, P. M. Wahl, N. Blumenthal, C. Archer, and L. R. Kaiser BILATERAL VERSUS SINGLE LUNG TRANSPLANTATION FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE J. Thorac. Cardiovasc. Surg., March 1, 1997; 113(3): 520 - 528. [Abstract] [Full Text]

				R. S. Sundaresan, Y. Shiraishi, E. P. Trulock, J. Manley, J. Lynch, J. D. Cooper, and G. A. Patterson CARDIAC AND PULMONARY REPLACEMENTSINGLE OR BILATERAL LUNG TRANSPLANTATION FOR EMPHYSEMA? J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1485 - 1495. [Abstract] [Full Text]

				T. J. Kroshus, R. M. Bolman III, and V. R. Kshettry Unilateral Volume Reduction After Single-Lung Transplantation for Emphysema Ann. Thorac. Surg., August 1, 1996; 62(2): 363 - 368. [Abstract] [Full Text]

				K. S. Naunheim and M. K. Ferguson The Current Status of Lung Volume Reduction Operations for Emphysema Ann. Thorac. Surg., August 1, 1996; 62(2): 601 - 612. [Abstract] [Full Text]

				K. Bando, R. J. Keenan, I. L. Paradis, H. Konishi, K. Komatsu, R. L. Hardesty, and B. P. Griffith Impact of pulmonary hypertension on outcome after single-lung transplantation Ann. Thorac. Surg., November 1, 1994; 58(5): 1336 - 1342. [Abstract] [PDF]

				C. G. A. McGregor, R. C. Daly, S. G. Peters, D. E. Midthun, J. P. Scott, M. S. Alien, H. D. Tazelaar, M. R. Keating, R. C. Walker, and J. C. McDougall Evolving strategies in lung transplantation for emphysema Ann. Thorac. Surg., June 1, 1994; 57(6): 1513 - 1520. [Abstract] [PDF]

				C. Dromer, J.-F. Velly, J. Jougon, C. Martigne, E. M. Baudet, L. Couraud, and The Bordeaux Lung and Heart-Lung Transplant Group Long-term functional results after bilateral lung transplantation Ann. Thorac. Surg., July 1, 1993; 56(1): 68 - 73. [Abstract] [PDF]

				Diagnostic and Therapeutic Technology Assessment (DATTA) JAMA, February 17, 1993; 269(7): 931 - 936. [PDF]

				P. Y. Brichon, D. Blin, I. Perez, C. Pison, F. Blanc-Jouvan, I. Pin, D. Barnoud, E. Brambilla, and R. Latreille Double-lung transplantation using donor lungs with a right tracheal bronchus Ann. Thorac. Surg., October 1, 1992; 54(4): 777 - 778. [Abstract] [PDF]

				R. J. Novick, A. H. Menkis, D. Sandler, A. Garg, D. Ahmad, S. Williams, and F. N. McKenzie Contralateral pneumonectomy after single-lung transplantation for emphysema Ann. Thorac. Surg., December 1, 1991; 52(6): 1317 - 1319. [Abstract] [PDF]