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The Journal of Thoracic and Cardiovascular Surgery, Vol 101, 654-660, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
V Videm, TE Mollnes, P Garred and JL Svennevig
Oxygenator/tubing sets coated with endpoint-attached heparin were compared
to uncoated sets in a dynamic model of extracorporeal circulation.
Biocompatibility was assessed by evaluations of complement activation and
platelet loss. The median concentration of C3 activation products increased
gradually from 12 AU/ml at baseline to 65 AU/ml after 120 minutes in the
uncoated sets and from 12 AU/ml to 19 AU/ml after 120 minutes in the coated
sets (p less than 0.002). The median concentration of the terminal
complement complex in the uncoated sets increased gradually from 3.1 AU/ml
at baseline to 18.2 AU/ml after 120 minutes. In the coated sets the
terminal complement complex reached a peak of 12.0 AU/ml at 15 minutes and
returned to baseline values at 60 minutes. Median platelet loss at 120
minutes was 166 x 10(9) in the uncoated and 21 x 10(9) in the coated sets
(p less than 0.01). Heparin coating thus improved biocompatibility by
reducing both complement activation and platelet loss.
ARTICLES
Biocompatibility of extracorporeal circulation. In vitro comparison of heparin-coated and uncoated oxygenator circuits
Institute for Experimental Medical Research, Ullevaal Hospital, Oslo, Norway.
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R. C. Gorman, N. P. Ziats, A. K. Rao, N. Gikakis, L. Sun, M. M. H. Khan, N. Stenach, S. Sapatnekar, V. Chouhan, J. H. Gorman III, et al. SURFACE-BOUND HEPARIN FAILS TO REDUCE THROMBIN FORMATION DURING CLINICAL CARDIOPULMONARY BYPASS J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 1 - 12. [Abstract] [Full Text]
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E. Ovrum, T. E. Mollnes, E. Fosse, E. Am Holen, G. Tangen, M.-A. L. Ringdal, and V. Videm High and low heparin dose with heparin-coated cardiopulmonary bypass: Activation of complement and granulocytes Ann. Thorac. Surg., December 1, 1995; 60(6): 1755 - 1761. [Abstract] [PDF]
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E. Ovrum, T. E. Mollnes, E. Fosse, E. A. Holen, G. Tangen, M. Abdelnoor, M.-A. L. Ringdal, R. Oystese, and P. Venge COMPLEMENT AND GRANULOCYTE ACTIVATION IN TWO DIFFERENT TYPES OF HEPARINIZED EXTRACORPOREAL CIRCUITS J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1623 - 1632. [Abstract] [Full Text]
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P. G. M. Jansen, H. t. Velthuis, R. A. J. M. Huybregts, R. Paulus, E. R. Bulder, H. I. van der Spoel, P. D. Bezemer, E. H. Slaats, L. Eijsman, and C. R. H. Wildevuur Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 829 - 834. [Abstract] [Full Text]
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D. D. Muehrcke, P. M. McCarthy, R. W. Stewart, S. Seshagiri, D. A. Ogella, R. C. Foster, and D. M. Cosgrove Complications of extracorporeal life support systems using heparin-bound surfaces: The risk of intracardiac clot formation J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 843 - 851. [Abstract] [Full Text]
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J. de Haan, P. W. Boonstra, S. H. J. Monnink, T. Ebels, and W. van Oeveren Retransfusion of suctioned blood during cardiopulmonary bypass impairs hemostasis Ann. Thorac. Surg., April 1, 1995; 59(4): 901 - 907. [Abstract] [PDF]
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L. H. Edmunds Jr Surface-bound heparin--Panacea or peril? Ann. Thorac. Surg., August 1, 1994; 58(2): 285 - 286. [PDF]
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M. Pekna, L. Hagman, E. Halden, U. R. Nilsson, B. Nilsson, and S. Thelin Complement activation during cardiopulmonary bypass: Effects of immobilized heparin Ann. Thorac. Surg., August 1, 1994; 58(2): 421 - 424. [Abstract] [PDF]
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E. Fosse, O. Moen, E. Johnson, G. Semb, V. Brockmeier, T. E. Mollnes, M. K. Fagerhol, and P. Venge Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass Ann. Thorac. Surg., August 1, 1994; 58(2): 472 - 477. [Abstract] [PDF]
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G. J. Magovern Jr., J. A. Magovern, D. H. Benckart, R. R. Lazzara, T. Sakert, T. D. Maher Jr., and R. E. Clark Extracorporeal membrane oxygenation: Preliminary results in patients with postcardiotomy cardiogenic shock Ann. Thorac. Surg., June 1, 1994; 57(6): 1462 - 1470. [Abstract] [PDF]
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D. R. Jones, R. C. Hill, A. Vasilakis, M. J. Hollingsed, G. M. Graeber, R. A. Gustafson, J. L. Cruzzavala, and G. F. Murray Safe use of heparin-coated bypass circuits incorporating a pump-oxygenator Ann. Thorac. Surg., April 1, 1994; 57(4): 815 - 819. [Abstract] [PDF]
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O. Moen, E. Fosse, J. Braten, C. Andersson, M. K. Fagerhol, P. Venge, K. Hegasen, and T. E. Mollnes Roller and centrifugal pumps compared in vitro with regard to haemolysis, granulocyte and complement activation Perfusion, March 1, 1994; 9(2): 109 - 117. [Abstract] [PDF]
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P. W. Boonstra, Y. J. Gu, C. Akkerman, J. Haan, R. Huyzen, and W. van Oeveren Heparin coating of an extracorporeal circuit partly improves hemostasis after cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 289 - 292. [Abstract] [Full Text]
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J. W. Borowiec, A. Bylock, J. van der Linden, and S. Thelin Heparin coating reduces blood cell adhesion to arterial filters during coronary bypass: A clinical study Ann. Thorac. Surg., June 1, 1993; 55(6): 1540 - 1545. [Abstract] [PDF]
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P. Garred, E. Fosse, M. K. Fagerhol, V. Videm, and T. E. Mollnes Calprotectin and complement activation during major operations with or without cardiopulmonary bypass Ann. Thorac. Surg., March 1, 1993; 55(3): 694 - 699. [Abstract] [PDF]
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F. B Plotz, W. R Wildevuur, C. R. Wildevuur, R. E Delius, and R. H Bartlett Platelet consumption during neonatal extracorporeal life support (ECLS) Perfusion, January 1, 1992; 7(1): 27 - 33. [Abstract] [PDF]
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