JTCS KCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rickaby, D. A.
Right arrow Articles by Dawson, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rickaby, D. A.
Right arrow Articles by Dawson, C. A.

The Journal of Thoracic and Cardiovascular Surgery, Vol 101, 732-739, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Tolerance of the isolated perfused lung to hyperthermia

DA Rickaby, JF Fehring, MR Johnston and CA Dawson
Department of Physiology, Medical College of Wisconsin, Milwaukee.

With the use of in vivo isolated lung perfusion for targeting antitumor therapy in the treatment of lung cancer, tolerance of normal lung tissue to the tumoricidal conditions becomes the limiting factor. This study was performed to determine the short-term tolerance of the lung to hyperthermia. Isolated dog lung lobes were perfused with autologous blood or an artificial salt solution at constant flow. Measurements of lung weight, extravascular water, vascular volume, serotonin uptake, urea permeability surface area product, perfusion pressure, and lung compliance were made with the temperature at about 37 degrees C. The temperature was then set at between 37 degrees and 45 degrees C, and at the end of the subsequent 2 hours the measurements were repeated. When the temperature was less than about 44.4 degrees C, hyperthermia had no detectable influence on the measured variables. Thus on the time frame consistent with in vivo perfusion therapy the normal lung appears to tolerate a fairly severe hyperthermia.


This article has been cited by other articles:


Home page
 PerfusionHome page
M. J. Grootenboers, J. Heeren, B. P Van putte, J. M. Hendriks, W. J Van boven, P. E. Van schil, and F. M. Schramel
Isolated lung perfusion for pulmonary metastases, a review and work in progress
Perfusion, September 1, 2006; 21(5): 267 - 276.
[Abstract] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
U. F. W. Franke, T. Wittwer, M. Lessel, K. Liebing, M. Albert, V. Becker, H. Schubert, and T. Wahlers
Evaluation of isolated lung perfusion as neoadjuvant therapy of lung metastases using a novel in vivo pig model: I. Influence of perfusion pressure and hyperthermia on functional and morphological lung integrity
Eur J Cardiothorac Surg, October 1, 2004; 26(4): 792 - 799.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
U. F. W. Franke, T. Wittwer, M. Kaluza, M. Albert, V. Becker, M. Roskos, M. Lessel, and T. Wahlers
Evaluation of isolated lung perfusion as neoadjuvant therapy of lung metastases using a novel in vivo pig model: II. High-dose cisplatin is well tolerated by the native lung tissue
Eur J Cardiothorac Surg, October 1, 2004; 26(4): 800 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
A. Toker, K. Bostanci, D. Yilmazbayhan, E. Dayioglu, and E. Onursal
Effects of Ventilation on Lung Function After Normothermic Ischemia
Asian Cardiovasc Thorac Ann, December 1, 1999; 7(4): 309 - 312.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. V. Clough, S. T. Haworth, C. C. Hanger, J. Wang, D. L. Roerig, J. H. Linehan, and C. A. Dawson
Transit time dispersion in the pulmonary arterial tree
J Appl Physiol, August 1, 1998; 85(2): 565 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Nawata, N. Abecasis, H. M. Ross, A. Abolhoda, H. Cheng, K. S. Sachar, and M. E. Burt
ISOLATED LUNG PERFUSION WITH MELPHALAN FOR THE TREATMENT OF METASTATIC PULMONARY SARCOMA
J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1542 - 1548.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. B. Ratto, S. Toma, D. Civalleri, G. C. Passerone, M. Esposito, D. Zaccheo, M. Canepa, P. Romano, R. Palumbo, F. De Cian, et al.
ISOLATED LUNG PERFUSION WITH PLATINUM IN THE TREATMENT OF PULMONARY METASTASES FROM SOFT TISSUE SARCOMAS
J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 614 - 622.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
H. I. Pass, D. J. Y. Mew, K. C. Kranda, B. K. Temeck, J. S. Donington, and S. A. Rosenberg
Isolated Lung Perfusion With Tumor Necrosis Factor for Pulmonary Metastases
Ann. Thorac. Surg., June 1, 1996; 61(6): 1609 - 1617.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. R. Johnston, R. F. Minchen, and C. A. Dawson
LUNG PERFUSION WITH CHEMOTHERAPY IN PATIENTS WITH UNRESECTABLE METASTATIC SARCOMA TO THE LUNG OR DIFFUSE BRONCHIOLOALVEOLAR CARCINOMA
J. Thorac. Cardiovasc. Surg., August 1, 1995; 110(2): 368 - 373.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
H. W. Pogrebniak, C. J. Witt, R. Terrill, K. Kranda, W. D. Travis, S. A. Rosenberg, and H. I. Pass
Isolated lung perfusion with tumor necrosis factor: A swine model in preparation of human trials
Ann. Thorac. Surg., June 1, 1994; 57(6): 1477 - 1483.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1991 by The American Association for Thoracic Surgery.