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The Journal of Thoracic and Cardiovascular Surgery, Vol 103, 1214-1217, Copyright © 1992 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Prognostic significance of tumor deoxyribonucleic acid content in surgically resected small-cell carcinoma of lung

FA Carey, US Prasad, WS Walker, EW Cameron, D Lamb and CC Bird
Department of Pathology, University of Edinburgh, United Kingdom.

The prognostic role of deoxyribonucleic acid flow cytometry was investigated in 53 cases of surgically resected small-cell lung cancer. Deoxyribonucleic acid aneuploidy was detected in 26 patients (49.1%), the remaining tumors being either diploid or tetraploid. Patients with aneuploid tumors had a significantly reduced 2-year survival (38.5%) when compared with patients with diploid or tetraploid tumors (70.3%; p less than 0.05). This finding was independent of tumor stage on multiple logistic regression analysis. Diploid or tetraploid deoxyribonucleic acid content was associated with a particularly good 2- year survival (85%) in N0 or N1 disease. Tumor deoxyribonucleic acid ploidy should be taken into account in planning of management and assessment of prognosis in small-cell lung cancer.


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[Abstract] [Full Text] [PDF]


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Copyright © 1992 by The American Association for Thoracic Surgery.