JTCS Speed Up Your Browser
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liewald, F.
Right arrow Articles by Sunder-Plassmann, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liewald, F.
Right arrow Articles by Sunder-Plassmann, L.

The Journal of Thoracic and Cardiovascular Surgery, Vol 104, 408-412, Copyright © 1992 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Importance of microscopic residual disease at the bronchial margin after resection for non-small-cell carcinoma of the lung

F Liewald, RA Hatz, H Dienemann and L Sunder-Plassmann
Department of Surgery, Klinikum Grosshadern, Ludwig-Maximilians University Medical School, Munich, Germany.

A total of 805 patients underwent lung resection for non-small-cell lung carcinoma at the University of Munich Medical Center, Klinikum Grosshadern, from 1978 through 1988. Microscopic residual disease at the bronchial margin was found in 21 patients (2.6%). The tumor residues showed either a mucosal (1%) or a extramucosal (1.6%) spreading pattern. Patients with extramucosal microscopic residual disease had a poorer prognosis (median survival 10.3 months) than patients with mucosal microscopic residual disease (median survival 25 months). The prognosis was better if the tumor was squamous cell as opposed to adenocarcinoma or large-cell carcinoma. The most important prognostic factor was tumor stage. Patients with microscopic tumor infiltration and stage I or II disease survived longer than the comparable stage III group. We suggest that these patients should undergo reoperation, if possible. Patients with stage III disease, mediastinal lymph node involvement, and microscopic residual disease have the same marked reduction in survival as patients with stage III disease but without microscopic tumor infiltration. We do not recommend a follow-up operation in these patients. Complete histologic examination of mucosal and extramucosal peribronchial tissues at the resection line by frozen section is mandatory to avoid leaving microscopic tumor behind, which may adversely affect patient survival.


This article has been cited by other articles:


Home page
 ICVTSHome page
E. Fernandez, P. L. de Castro, J. Astudillo, J. Fernandez-Llamazares, and and GCCB-S (Bronchogenic Carcinoma Cooperative Gro
Bronchial stump infiltration after lung cancer surgery. Retrospective study of a series of 2994 patients
Interactive CardioVascular and Thoracic Surgery, August 1, 2009; 9(2): 182 - 186.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Collaud, M. Bongiovanni, J.-C. Pache, G. Fioretta, and J. H. Robert
Survival according to the site of bronchial microscopic residual disease after lung resection for non-small cell lung cancer.
J. Thorac. Cardiovasc. Surg., March 1, 2009; 137(3): 622 - 626.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
J. Wind, E. J. Smit, S. Senan, and J.-P. Eerenberg
Residual disease at the bronchial stump after curative resection for lung cancer
Eur. J. Cardiothorac. Surg., July 1, 2007; 32(1): 29 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. G. Little, V. W. Rusch, J. A. Bonner, L. E. Gaspar, M. R. Green, W. R. Webb, and A. K. Stewart
Patterns of Surgical Care of Lung Cancer Patients
Ann. Thorac. Surg., December 1, 2005; 80(6): 2051 - 2056.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
S. Balasubramanian, J. Au, and J. Dunning
Should lobectomy patients with microscopic involvement of the bronchial resection margin undergo re-operation to improve their long-term survival?
Interactive CardioVascular and Thoracic Surgery, December 1, 2005; 4(6): 531 - 537.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Pasic, K. Grunberg, W. J. Mooi, M. A. Paul, P. E. Postmus, and T. G. Sutedja
The Natural History of Carcinoma In Situ Involving Bronchial Resection Margins
Chest, September 1, 2005; 128(3): 1736 - 1741.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Guo, M. G. House, C. Hooker, Y. Han, E. Heath, E. Gabrielson, S. C. Yang, S. B. Baylin, J. G. Herman, and M. V. Brock
Promoter Hypermethylation of Resected Bronchial Margins: A Field Defect of Changes?
Clin. Cancer Res., August 1, 2004; 10(15): 5131 - 5136.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. E.B. Swinson, J. L. Jones, D. Richardson, C. Wykoff, H. Turley, J. Pastorek, N. Taub, A. L. Harris, and K. J. O'Byrne
Carbonic Anhydrase IX Expression, a Novel Surrogate Marker of Tumor Hypoxia, Is Associated With a Poor Prognosis in Non-Small-Cell Lung Cancer
J. Clin. Oncol., February 1, 2003; 21(3): 473 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
H.S. Hofmann, C. Taege, C. Lautenschlager, H. Neef, and R.E. Silber
Microscopic (R1) and macroscopic (R2) residual disease in patients with resected non-small cell lung cancer
Eur. J. Cardiothorac. Surg., April 1, 2002; 21(4): 606 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. Passlick, I. Sitar, W. Sienel, O. Thetter, and A. Morresi-Hauf
Significance of lymphangiosis carcinomatosa at the bronchial resection margin in patients with non-small cell lung cancer
Ann. Thorac. Surg., October 1, 2001; 72(4): 1160 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
M. Kara, S. Dizbay Sak, D. Orhan, and S. Kavukcu
Proximal bronchial extension with special reference to tumor localization in non-small cell lung cancer
Eur. J. Cardiothorac. Surg., August 1, 2001; 20(2): 350 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
G. Massard, C. Doddoli, B. Gasser, X. Ducrocq, R. Kessler, C. Schumacher, G.-M. Jung, and J.-M. Wihlm
Prognostic implications of a positive bronchial resection margin
Eur. J. Cardiothorac. Surg., May 1, 2000; 17(5): 557 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
C. Ghiribelli, L. Voltolini, P. Paladini, L. Luzzi, M. Di Bisceglie, and G. Gotti
Treatment and survival after lung resection for non-small cell lung cancer in patients with microscopic residual disease at the bronchial stump
Eur. J. Cardiothorac. Surg., November 1, 1999; 16(5): 555 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Lacasse, H. C. Bucher, E. Wong, L. Griffith, S. Walter, R. J. Ginsberg, and G. H. Guyatt MD,
"Incomplete Resection" in Non-Small Cell Lung Cancer: Need for a New Definition
Ann. Thorac. Surg., January 1, 1998; 65(1): 220 - 226.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1992 by The American Association for Thoracic Surgery.