HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Inui, K. Articles by Borst, H. G. Search for Related Content PubMed PubMed Citation Articles by Inui, K. Articles by Borst, H. G.

The Journal of Thoracic and Cardiovascular Surgery, Vol 105, 474-478, Copyright © 1993 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Bronchial circulation after experimental lung transplantation. The effect of long-term administration of prednisolone

K Inui, HJ Schafers, M Aoki, V Becker, B Ongsiek, J Kemnitz, A Haverich and HG Borst
Department of Pathology, Hannover Medical School, Germany.

The effect of corticosteroids on bronchial healing after modified left lung transplantation was investigated in pigs. In groups I (n = 6) and II (n = 6), animals received cyclosporine (15 mg/kg per day) and azathioprine (2 mg/kg per day). In group II, prednisolone (1 mg/kg per day) was also administered. Bronchial blood flow was estimated at the donor carina and donor second carina with laser Doppler velocimetry and radioisotopes 7 days postoperatively; macroscopic and microscopic assessments of graft airways were performed. Bronchial blood was calculated relative to the recipient carina. In group II, bronchial blood flow at the donor carina and donor second carina was significantly higher than that of group I. Macroscopic assessment revealed more pronounced ischemic changes in group I (5 of 6 animals) than in group II (2 of 6 animals, p = not significant). Microscopically, airway samples from the donor carina revealed marked destructive changes in five of six animals in group I. In group II, only mild ischemic changes, which were limited to the respiratory epithelium, were seen. We concluded that the administration of prednisolone results in improved bronchial blood flow and decreased bronchial ischemia after lung transplantation.

This article has been cited by other articles:

				A. E. Dutly, A. Gaspert, I. Inci, D. Schneiter, S. Korom, and W. Weder The influence of the rapamycin-derivate SDZ RAD on the healing of airway anastomoses Eur. J. Cardiothorac. Surg., July 1, 2003; 24(1): 154 - 158. [Abstract] [Full Text] [PDF]

				C. Schroder, F. Scholl, E. Daon, A. Goodwin, W. H. Frist, J. R. Roberts, K. G. Christian, M. Ninan, A. P. Milstone, J. E. Loyd, et al. A modified bronchial anastomosis technique for lung transplantation Ann. Thorac. Surg., June 1, 2003; 75(6): 1697 - 1704. [Abstract] [Full Text] [PDF]

				U. Herold, H. Jakob, M. Kamler, R. Thiele, U. Tochtermann, J. Weinmann, J. Motsch, M. M. Gebhard, and S. Hagl Interruption of bronchial circulation leads to a severe decrease in peribronchial oxygen tension in standard lung transplantation technique Eur. J. Cardiothorac. Surg., February 1, 1998; 13(2): 176 - 183. [Abstract] [Full Text] [PDF]

				H. Date, E. P. Trulock, J. M. Arcidi, S. Sundaresan, J. D. Cooper, and G. A. Patterson IMPROVED AIRWAY HEALING AFTER LUNG TRANSPLANTATIONAn analysis of 348 bronchial anastomoses J. Thorac. Cardiovasc. Surg., November 1, 1995; 110(5): 1424 - 1433. [Abstract] [Full Text]

				K. Uthoff, K. J. Zehr, P. B. Gaudin, P. Kumar, P. W. Cho, G. Vogelsang, R. H. Hruban, W. A. Baumgartner, and R. S. Stuart Thalidomide as Replacement for Steroids in Immunosuppression After Lung Transplantation Ann. Thorac. Surg., February 1, 1995; 59(2): 277 - 282. [Abstract] [Full Text]

				H.-J. Schafers, C. M. Schafer, C. Zink, A. Haverich, and H. G. Borst Surgical treatment of airway complications after lung transplantation J. Thorac. Cardiovasc. Surg., June 1, 1994; 107(6): 1476 - 1480. [Abstract] [Full Text]

				M. Takao, H. Tanabe, I. Yada, S. Namikawa, H. Yuasa, and M. Kusagawa Bronchial circulation and airway complications after lung transplantation: Possible role of pulmonary rejection J. Thorac. Cardiovasc. Surg., March 1, 1994; 107(3): 945 - 947. [Full Text]

				K. Inui and H.-J. Schafers Bronchial circulation and airway complications after lung transplantation: Possible role of pulmonary rejection J. Thorac. Cardiovasc. Surg., March 1, 1994; 107(3): 946 - 947. [Full Text]