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The Journal of Thoracic and Cardiovascular Surgery, Vol 105, 492-501, Copyright © 1993 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
H Date, A Matsumura, JK Manchester, JM Cooper, OH Lowry and JD Cooper
The lung is the only organ to which oxygen may be supplied after its blood
supply is stopped. Before this study, we were not certain whether lung
cells were able to maintain aerobic metabolism with the oxygen in the
alveoli during preservation. Excised rabbit lungs were used to measure
changes in the concentration of oxygen and carbon dioxide in the airway and
changes in glucose, glucose-6-phosphate, lactate, adenosine triphosphate,
and phosphocreatine levels in the lung tissue during preservation under
different conditions. Twenty-seven lungs were flushed with low-potassium
dextran electrolyte solution, inflated with room air, and preserved at 1
degree C (n = 8), 10 degrees C (n = 8), or 22 degrees (n = 11) for 4, 12,
or 24 hours. Eight additional lungs were inflated with 100% nitrogen and
preserved at 10 degrees C for 4 (n = 4) or 24 (n = 4) hours. Oxygen levels
decreased and carbon dioxide levels increased in the airway of the lungs
that were inflated with room air at rates dependent on the preservation
temperature. The increase of carbon dioxide in the lungs that were inflated
with 100% nitrogen was very small. When the oxygen was not available in the
alveoli, lactate accumulated, and adenosine triphosphate and
phosphocreatine decreased in the lung tissue. We concluded that lung cells
are able to maintain aerobic metabolism with the oxygen in the alveoli
during preservation and that the maintenance of aerobic metabolism may be
essential to maintain the optimum viability of preserved lung tissue.
ARTICLES
Changes in alveolar oxygen and carbon dioxide concentration and oxygen consumption during lung preservation. The maintenance of aerobic metabolism during lung preservation
Department of Surgery, Washington University School of Medicine, St. Louis, Mo.
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