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The Journal of Thoracic and Cardiovascular Surgery, Vol 106, 154-165, Copyright © 1993 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Long-term function of cryopreserved aortic homografts. A ten-year study

JK Kirklin, D Smith, W Novick, DC Naftel, JW Kirklin, AD Pacifico, NC Nanda, FR Helmcke and RC Bourge
Department of Surgery, University of Alabama, Birmingham 35294-0007.

Cryopreserved aortic valve homografts have become an accepted aortic valve substitute, but long-term studies with echocardiographic assessment of valve function are largely unavailable. Between 1981 and January 1, 1991, a total of 178 patients aged 9 months to 80 years (median 46 years) underwent implantation of a cryopreserved aortic valve homograft. Serial two-dimensional Doppler echocardiographic studies were obtained in 149 patients. Overall survival was 91% at 1 year and 85% at 8 years. Survival of patients undergoing isolated primary infracoronary aortic valve replacement was 99% at 1 month and 94% at 8 years. Twelve patients underwent homograft explanation. Freedom from explantation for leaflet degeneration was 95% at 8 years. Freedom from presumed leaflet failure (valve degeneration at explantation or aortic insufficiency grade 3/4 or more without reoperation on echocardiography) was 94% at 5 years and 85% at 8 years. By multivariable analysis younger recipient age was the only risk factor identified for leaflet failure. Ninety-five percent of patients followed up for 4 or more years were in New York Heart Association class I or II.


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RELIABLE CRYOPRESERVATION OF TRACHEA FOR ONE MONTH IN A NEW TREHALOSE SOLUTION
J. Thorac. Cardiovasc. Surg., August 1, 1995; 110(2): 382 - 385.
[Abstract] [Full Text]

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 Ann. Thorac. Surg.Home page
J. E. Rubay, D. Raphael, T. Sluysmans, J.-L. J. Vanoverschelde, A. Robert, J.-C. Schoevaerdts, B. Marchandise, and R. A. Dion
Aortic valve replacement with allograft/autograft: subcoronary versus intraluminal cylinder or root
Ann. Thorac. Surg., August 1, 1995; 60(suppl_2): S78 - S82.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
T. P. Willems, L. A. van Herwerden, E. W. Steyerberg, M. A. Taams, V. E. Kleyburg, R. B. Hokken, J. R. T. C. Roelandt, and E. Bos
Subcoronary implantation or aortic root replacement for human tissue valves: Sufficient data to prefer either technique?
Ann. Thorac. Surg., August 1, 1995; 60(suppl_2): S83 - S86.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
T. M. Sundt III, N. Rasmi, K. Wong, R. Radley-Smith, A. Khaghani, and M. H. Yacoub
Reoperative aortic valve operation after homograft root replacement: Surgical options and results
Ann. Thorac. Surg., August 1, 1995; 60(suppl_2): S95 - S100.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
R. N. Mitchell, R. A. Jonas, and F. J. Schoen
Structure-function correlations in cryopreserved allograft cardiac valves
Ann. Thorac. Surg., August 1, 1995; 60(suppl_2): S108 - S113.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
M. Valante, G. Faggian, M. E. Billingham, E. Talenti, F. Calabrese, R. Casula, N. E. Shumway, and G. Thiene
The aortic valve after heart transplantation
Ann. Thorac. Surg., August 1, 1995; 60(suppl_2): S135 - S140.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
C. Gross, W. Harringer, R. Mair, G. Wimmer-Greinecker, U. Klima, K. Sihorsch, R. Hofmann, H. Beran, and P. Brucke
Aortic valve replacement: Is the stentless xenograft an alternative to the homograft? early results of a randomized study
Ann. Thorac. Surg., August 1, 1995; 60(suppl_2): S418 - S421.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
S. Westaby, N. Amarasena, O. Ormerod, G. A. Chandima Amarasena, and R. Pillai
Aortic valve replacement with the freestyle stentless xenograft
Ann. Thorac. Surg., August 1, 1995; 60(suppl_2): S422 - S427.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
M. C. Felger, O. L. Miller, J. H. Calhoon, E. Y. Sako, S. B. Johnson, G. P. Wittpenn, and J. K. Trinkle
Homograft patch repair for hemorrhagic mediastinitis
Ann. Thorac. Surg., July 1, 1995; 60(1): 190 - 191.
[Abstract] [PDF]

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 J. Thorac. Cardiovasc. Surg.Home page
M. Yacoub, N. R. H. Rasmi, T. M. Sundt, O. Lund, E. Boyland, R. Radley-Smith, A. Khaghani, and A. Mitchell
Fourteen-year experience with homovital homografts for aortic valve replacement
J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 186 - 194.
[Abstract] [Full Text]

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 J. Thorac. Cardiovasc. Surg.Home page
K. Tamura, M. Jones, I. Yamada, and V. J. Ferrans
A comparison of failure modes of glutaraldehyde-treated versus antibiotic-preserved mitral valve allografts implanted in sheep
J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 224 - 238.
[Abstract] [Full Text]

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 J. Thorac. Cardiovasc. Surg.Home page
M. G. Hazekamp, D. R. Koolbergen, J. Braun, H. Sugihara, C. J. Cornelisse, Y. A. Goffin, and H. A. Huysmans
In situ hybridization: A new technique to determine the origin of fibroblasts in cryopreserved aortic homograft valve explants
J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 248 - 257.
[Abstract] [Full Text]

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E. L. Jones, V. B. Shah, J. S. Shanewise, T. D. Martin, R. P. Martin, J. A. Coto, R. Broniec, and Y. Shen
Should the freehand allograft be abandoned as a reliable alternative for aortic valve replacement?
Ann. Thorac. Surg., June 1, 1995; 59(6): 1397 - 1404.
[Abstract] [PDF]

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 J. Thorac. Cardiovasc. Surg.Home page
P. Vogt, M. Pasic, L. von Segesser, T. Carrel, and M. Turina
Cryopreserved aortic homograft for mycotic aneurysm
J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 589 - 591.
[Full Text]

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 J. Thorac. Cardiovasc. Surg.Home page
T. E. David, C. M. Feindel, J. Bos, Z. Sun, H. E. Scully, and H. Rakowski
Aortic valve replacement with a stentless porcine aortic valveA six-year experience
J. Thorac. Cardiovasc. Surg., December 1, 1994; 108(6): 1030 - 1036.
[Abstract] [Full Text]

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 J. Thorac. Cardiovasc. Surg.Home page
D. C. McGiffin
Invited letter concerning: Leaflet viability and the durability of the allograft aortic valve
J. Thorac. Cardiovasc. Surg., November 1, 1994; 108(5): 988 - 990.
[Full Text]

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 Ann. Thorac. Surg.Home page
C. J. Knott-Craig, R. C. Elkins, P. L. Stelzer, J. D. Randolph, C. McCue, P. A. Wright, and M. M. Lane
Homograft replacement of the aortic valve and root as a functional unit
Ann. Thorac. Surg., June 1, 1994; 57(6): 1501 - 1506.
[Abstract] [PDF]

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 Ann. Thorac. Surg.Home page
D. B. Doty, G. Michielon, N.-D. Wang, A. S. Cain, and R. C. Millar
Replacement of the aortic valve with cryopreserved aortic allograft
Ann. Thorac. Surg., August 1, 1993; 56(2): 228 - 236.
[Abstract] [PDF]


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