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The Journal of Thoracic and Cardiovascular Surgery, Vol 106, 703-708, Copyright © 1993 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
M Ohta, R Tsuchiya, M Shimoyama, K Sawamura, T Mori, N Miyazawa, K Suemasu, Y Watanabe, M Tomita and M Terashima
Two hundred nine patients with completely resected stage III non-small-
cell lung cancer were randomized to receive postoperative cisplatin and
vindesine chemotherapy or no further treatment. Before randomization,
patients were stratified by the histologic characteristics of their tumors
(squamous versus nonsquamous cell carcinoma). Prognostic variables such as
histology, performance status, extent of operation, and tumor and nodal
status of the eligible patients in chemotherapy (n = 90) and control groups
(n = 91) were equally distributed. There was no statistically significant
difference in disease-free and overall survival between the two groups. The
3-year disease-free survivals of the chemotherapy and control groups were
37% and 42%, respectively. The median survival times (5-year survival) were
31 months (35%) in the chemotherapy group and 37 months (41%) in the
control group. These was no different pattern in the first site of
recurrence (local versus systemic) between the two groups. This study
failed to demonstrate the therapeutic benefits of postoperative cisplatin
and vindesine chemotherapy.
ARTICLES
Adjuvant chemotherapy for completely resected stage III non-small-cell lung cancer. Results of a randomized prospective study. The Japan Clinical Oncology Group
National Kyushu Cancer Center, Fukuoka, Japan.
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L. H. Einhorn Neoadjuvant and Adjuvant Trials in Non-Small Cell Lung Cancer Ann. Thorac. Surg., January 1, 1998; 65(1): 208 - 211. [Abstract] [Full Text] [PDF]
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