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J Thorac Cardiovasc Surg 1994;107:210-215
© 1994 Mosby, Inc.

CARDIAC AND PULMONARY TRANSPLANTATION

Working heart model of heterotopic heart-lung transplantation in rats

Toshiyuki Maruyama, MD, Marc T. Swartz, Lawrence R. McBride, MD, D. Glenn Pennington, MD


St. Louis, Mo.

From the Department of Surgery, St. Louis University School of Medicine, St. Louis, Mo.

Received for publication Feb. 25, 1993. Accepted for publication May 4, 1993. Address for reprints: D. Glenn Pennington, MD, St. Louis University Hospital, 3635 Vista Ave. at Grand Blvd., P.O. Box 15250, St. Louis, MO 63110-0250.

Abstract

A technique for a working heart model of heterotopic heart-lung transplantation is described. The donor aorta and left pulmonary artery are anastomosed to the recipient's abdominal aorta in an end-to-side fashion. Arterial blood from the recipient's abdominal aorta enters the donor left heart via the donor left lung and is ejected into the donor ascending aorta by the transplanted left ventricle. With this model, the donor left ventricle performs work comparable to that of the native heart without hypoxia. This model is easily reproducible and can be applied to various studies, including long-term assessments of cardiac remodeling, long-term efficacy of cardiac preservation, and posttransplantation ventricular performance under more physiologic conditions. (J THORAC CARDIOVASC SURG 1994; 107:210-5)




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