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J Thorac Cardiovasc Surg 1994;107:242-247
© 1994 Mosby, Inc.

CARDIOPULMONARY BYPASS, MYOCARDIAL MANAGEMENT, AND SUPPORT TECHNIQUES

Effectiveness of coenzyme Q₁₀ on myocardial preservation during hypothermic cardioplegic arrest

Kaohsiung, Taiwan

From the Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Medical College, Kaohsiung, Taiwan.

Received for publication Oct. 22, 1992. Accepted for publication April 16, 1993. Address for reprints: Ying-Fu Chen, MD, Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Medical College, 100 Shih-Chuan 1st Rd., Kaohsiung, Taiwan.

Abstract

A prospective, randomized, double-blind trial assigned 11 patients to receive coenzyme Q₁₀ and 11 to receive none. Patients pretreated with coenzyme Q₁₀ had a lower left atrial pressure and a lesser incidence of low cardiac output. They also had a wider pulse pressure. The right and left ventricular myocardial ultrastructure was better preserved in patients receiving preoperative treatment with coenzyme Q₁₀. There was no demonstrable benefit to the atrial myocardium. (J THORAC CARDIOVASC SURG 1994;107:242-7)

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