HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Magdi H. Yacoub Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by O'Neil, G. S. Articles by Yacoub, M. H. Search for Related Content PubMed PubMed Citation Articles by O'Neil, G. S. Articles by Yacoub, M. H.

J Thorac Cardiovasc Surg 1994;107:699-706
© 1994 Mosby, Inc.

SURGERY FOR ACQUIRED HEART DISEASE

Effect of surgical preparation and arterialization on vasomotion of human saphenous vein

Harefield, Middlesex, United Kingdom

From the Department of Surgery, National Heart and Lung Institute, Harefield Hospital, Harefield, Middlesex, United Kingdom.

Received for publication June 7, 1993. Accepted for publication Sept. 24, 1993. Address for reprints: Magdi H. Yacoub, FRCS, Department of Surgery, National Heart and Lung Institute, Harefield Hospital, Harefield, Middlesex, UB9 6JH, United Kingdom.

Abstract

To gain an insight into venous physiologic adaptation to arterialization, this study examined the effects of thromboxane, 5-hydroxytryptamine, endothelin, leukotriene C₄, and norepinephrine on isolated segments of native and distended human saphenous vein, short-term (up to 1 year) grafts, and long-term (1 to 10 year) grafts. The mean maximum constrictor responses, expressed as percentage of maximum potassium depolarization, were as follows: thromboxane analog U46619: native vein 147.0% ± 10.5%, distended vein 251.2% ± 29.1%, short-term graft 174.6% ± 33.8%, long-term graft 220.9% ± 21.7%; 5-hydroxytryptamine: native vein 115.6% ± 6.1%, distended vein 129.9% ± 13.3%, short-term graft 80.0% ± 15.0%, long-term graft 95.1% ± 12.1%; endothelin-1: native vein 126.5% ± 22.1%, distended vein 138.1% ± 24.7%, short-term graft 120.7% ± 43.3%, long-term graft 171.4% ± 26.0%; leukotriene C₄: native vein 49.9% ± 8.7%, distended vein 78.9% ± 11.8%, short-term graft 90.8% ± 39.1%, long-term graft 7.4% ± 5.0%; and norepinephrine: native vein 127.0% ± 9.3%, distended vein 155.0% ± 17.8%, short-term graft 61.6% ± 11.3%, long-term graft 80.1% ± 7.7%. The vasoconstriction elicited by each agonist, in absolute terms (in millinewtons), diminished with age of graft. We conclude that surgical treatment of saphenous vein immediately renders it more responsive to U46619, norepinephrine, and leukotriene C₄. An agonist-specific profile of response was evident up to 10 years after operation, which may affect myocardial blood supply when luminal bore is diminished by vein graft disease. (J THORACCARDIOVASCSURG1994;107:699-706)

This article has been cited by other articles:

				T. Shintani, Y. Sawa, T. Takahashi, G. Matsumiya, N. Matsuura, Y. Miyamoto, and H. Matsuda Intraoperative transfection of vein grafts with the NF{kappa}B decoy in a canine aortocoronary bypass model: a strategy to attenuate intimal hyperplasia Ann. Thorac. Surg., October 1, 2002; 74(4): 1132 - 1137. [Abstract] [Full Text] [PDF]

				E. McGregor, M. Gosling, D. K Beattie, D. M.P Ribbons, A. H Davies, and J. T Powell Circumferential stretching of saphenous vein smooth muscle enhances vasoconstrictor responses by Rho kinase-dependent pathways Cardiovasc Res, January 1, 2002; 53(1): 219 - 226. [Abstract] [Full Text] [PDF]

				E. A. Black, T. J. Guzik, N. E.J. West, K. Campbell, R. Pillai, C. Ratnatunga, and K. M. Channon Minimally invasive saphenous vein harvesting: effects on endothelial and smooth muscle function Ann. Thorac. Surg., May 1, 2001; 71(5): 1503 - 1507. [Abstract] [Full Text] [PDF]

				Z.-G. Liu, X.-C. Liu, A. P.C. Yim, and G.-W. He Direct measurement of nitric oxide release from saphenous vein: abolishment by surgical preparation Ann. Thorac. Surg., January 1, 2001; 71(1): 133 - 137. [Abstract] [Full Text] [PDF]

				A. M. Fabricius, A. Oser, A. Diegeler, T. Rauch, and F. W. Mohr Endothelial function of human vena saphena magna prepared with different minimally invasive harvesting techniques Eur. J. Cardiothorac. Surg., October 1, 2000; 18(4): 400 - 403. [Abstract] [Full Text] [PDF]

				M. Ojha, R. L. Leask, K. W. Johnston, T. E. David, and J. Butany Histology and morphology of 59 internal thoracic artery grafts and their distal anastomoses Ann. Thorac. Surg., October 1, 2000; 70(4): 1338 - 1344. [Abstract] [Full Text] [PDF]

				M. Rinia-Feenstra, W. Stooker, R. de Graaf, J. J. Kloek, M. Pfaffendorf, B. A.J.M. de Mol, and P. A. van Zwieten Functional properties of the saphenous vein harvested by minimally invasive techniques Ann. Thorac. Surg., April 1, 2000; 69(4): 1116 - 1120. [Abstract] [Full Text] [PDF]

				J.-A. Yang and G.-W. He Surgical Preparation Abolishes Endothelium-Derived Hyperpolarizing Factor-Mediated Hyperpolarization in the Human Saphenous Vein Ann. Thorac. Surg., February 1, 1997; 63(2): 429 - 433. [Abstract] [Full Text]