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J Thorac Cardiovasc Surg 1994;107:934-940
© 1994 Mosby, Inc.


SURGERY FOR CONGENITAL HEART DISEASE

Improving results with first-stage palliation for hypoplastic left heart syndrome

Mark D. Iannettoni, MDa, Edward L. Bove, MDa, Ralph S. Mosca, MDa, Flavian M. Lupinetti, MDa, Parvin C. Dorostkar, MDb, Achi Ludomirsky, MDb, Dennis C. Crowley, MDb, Thomas J. Kulik, MDb, Amnon Rosenthal, MDb


Ann Arbor, Mich.

Presented at the Sixty-fifth Scientific Session of the American Heart Association, New Orleans, La., Nov. 17, 1992.

Received for publication April 23, 1993. Accepted for publication July 30, 1993. Address for reprints: Edward L. Bove, MD, 1500 East Medical Center Dr., 2120 Taubman Center, Box 0344, Ann Arbor, MI 48109.

Abstract

Between January 1990 and February 1993, 73 patients underwent first-stage reconstruction for hypoplastic left heart syndrome at the University of Michigan Medical Center. During this period, surgical reconstruction remained essentially constant and consisted of a pulmonary artery–to–aorta anastomosis with allograft augmentation of the ascending, transverse, and proximal descending aorta, restriction of pulmonary blood flow with a polytetrafluoroethylene shunt from the innominate artery to the central pulmonary artery confluence, and atrial septectomy. Hospital survival was 62 of 73 patients, 85% (70% confidence limits: 80% to 89%). These results stand in marked contrast to those obtained during the earlier years of our experience from 1986 to 1989 when only 21 of 50 patients (42%, 70% confidence limits: 35% to 49%) survived (p = 0.001). Among the most recent group of patients, only 2 of 7 patients older than 1 month of age at operation survived, whereas 60 of 66 (91%, 70% confidence limits: 87% to 94%) patients younger than 1 month of age survived (p = 0.0001). Anatomic subtype and ascending aortic diameter were not predictive of survival. Actuarial survivals for those patients younger than 1 month of age at the first-stage operation, including hospital deaths and subsequent operative procedures, were 81%, 74%, and 74% at 6 months, 1 year, and 2 years, respectively. These results indicate that survival for patients after first-stage reconstruction for hypoplastic left heart syndrome has significantly improved in recent years. Older age was a strong risk factor, with a hospital survival of 91% for those patients undergoing first-stage palliation within the first month of life. These data have important implications for the type of operative intervention and its timing. (J THORACCARDIOVASCSURG1994;107:934-40)




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