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J Thorac Cardiovasc Surg 1994;107:1391-1397
© 1994 Mosby, Inc.

GENERAL THORACIC SURGERY

High-dose irradiation prevents rejection of canine tracheal allografts

Kyoto, Japan

Received for publication June 1, 1993. Accepted for publication Sept. 24, 1993. Address for reprints: H. Yokomise, MD, Thoracic Surgery, Chest Disease Research Institute, Kyoto University, 53 Shogoin-Kawaharamachi, Sakyo-ku, Kyoto 606, Japan.

Abstract

We investigated the possibility of immunosuppressant-free transplantation of the trachea using high doses of ⁶⁰ Co irradiation of the graft before transplantation. Twenty mongrel dogs were used. Five rings of the trachea were removed from the donors and irradiated with ⁶⁰ Co rays. Five corresponding rings were removed from the thoracic trachea of the recipient dogs, and the irradiated trachea was transplanted. Five animals were placed in each of four dosage groups: group A, no irradiation; group B, 20,000 cGy; group C, 50,000 cGy; and group D, 100,000 cGy. The anastomotic site and graft were covered with a pedicled greater omentum graft. No immunosuppressants were given. In group A, all the animals died within 1 month of tracheal stenosis caused by graft rejection. In groups B and C, one animal in each group survived for a long period, but all the others died of tracheal stenosis caused by graft rejection. In group D (100,000 cGy), the graft became incorporated into the recipient tissue in four of the five animals, and three are still alive (more than 1 year later). These findings indicate that allotransplantation of the trachea without the use of immunosuppressants is possible with pretransplantation irradiation of the graft at the dose of 100,000 cGy. (J T HORAC C ARDIOVASC S URG 1994;107: 1391-7)

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