JTCS Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Carolyn E. Reed
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gates, C. E.
Right arrow Articles by Crawford, S. b. F. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gates, C. E.
Right arrow Articles by Crawford, S. b. F. A., Jr.

J Thorac Cardiovasc Surg 1994;108:148-152
© 1994 Mosby, Inc.

GENERAL THORACIC SURGERY

Prevalence of p53 mutations in patients with squamous cell carcinoma of the esophagus

Christopher E. Gates, MDa (by invitation), Carolyn E. Reed, MDa (by invitation), Jonathan S. Bromberg, MD, PhDa,b (by invitation), Eric T. Everett, PhDc (by invitation), Paul L. Baron, MDa (by invitation), Sponsored by Fred A. Crawford, Jr., MD


Charleston, S.C.

Supported in part by the American Cancer Society Clinical Oncology Career Development Award (P.L.B.).

Address for reprints: Paul L. Baron, MD, Department of Surgery, The Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425.

Abstract

Squamous cell carcinoma of the esophagus has an uneven geographic distribution with a strong prevalence in the South Carolina Lowcountry. Although many environmental influences and some genetic factors have been implicated in its development, the molecular events required for tumorigenesis have not been defined. Point mutations in the p53 tumor suppressor gene are the most commonly noted genetic defect in human tumors. Our study shows that p53 point mutations occur more frequently in patients with esophageal cancer from this region than in patients from other areas of the world where the disease is prevalent. (J THORACCARDIOVASCSURG1994;108:148-52)




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
E. Okuda, H. Osugi, K. Morimura, N. Takada, M. Takemura, S. Fukushima, M. Higashino, and H. Kinoshita
Detection of p53 Gene Mutations in Human Esophageal Squamous Cell Carcinomas Using a p53 Yeast Functional Assay: Possible Difference in Esophageal Carcinogenesis Between the Young and the Elderly Group
Clin. Cancer Res., March 1, 2001; 7(3): 600 - 606.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1994 by The American Association for Thoracic Surgery.