HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Shoichiro Shiraishi Takaaki Sugita Takehisa Nojima Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Watarida, S. Articles by Matsuno, S. Search for Related Content PubMed PubMed Citation Articles by Watarida, S. Articles by Matsuno, S.

J Thorac Cardiovasc Surg 1994;108:620-625
© 1994 Mosby, Inc.

CARDIOPULMONARY BYPASS, MYOCARDIAL MANAGEMENT, AND SUPPORT TECHNIQUES

A clinical study on the effects of pulsatile cardiopulmonary bypass on the blood endotoxin levels

Shiga, Japan

From The Second Department of Surgery, Shiga University of Medical Science, Otsu, Japan.

Received for publication Sept. 24, 1993. Accepted for publication March 16, 1994. Address for reprints: Shoji Watarida, MD, The Second Department of Surgery, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520-21, Japan.

Abstract

Levels of endogenous endotoxins have been reported to increase after cardiopulmonary bypass. Endotoxin levels have also been implicated in multiple organ failure and may contribute to the immunocompromised state seen after bypass. We evaluated the effects of pulsatile cardiopulmonary bypass circulation on endogenous endotoxin levels. The study population consisted of 15 consecutive adult patients who underwent cardiac operations with cardiopulmonary bypass. Pulsatile flow was used during aortic crossclamping in eight patients (group I) and nonpulsatile flow was used in the remaining seven patients (group II). Changes in blood endotoxin levels were monitored during aortic crossclamping, after release of the clamp, and after weaning from bypass. The blood endotoxin level at each stage was expressed as a percentage of the level at the beginning of bypass. Group I patients a significantly lower blood endotoxin percentage than group II (from 20 to 120 minutes after the initiation of aortic crossclamping). In group I, the blood endotoxin percentage was nearly constant during aortic crossclamping. After release of aortic crossclamping, group I also had a lower blood endotoxin percentage than group II. Endogenous endotoxin levels appear to increase in the presence of intestinal congestion and ischemia. Improvement in intestinal circulation by pulsatile cardiopulmonary bypass may prevent increases in endogenous endotoxin levels by reducing these factors. (J THORACCARDIOVASCSURG1994;108:620-5)

This article has been cited by other articles:

				Z.-y. Xia, X.-Y. Liu, L.-y. Zhan, Y.-h. He, T. Luo, and Z. Xia Ginsenosides compound (shen-fu) attenuates gastrointestinal injury and inhibits inflammatory response after cardiopulmonary bypass in patients with congenital heart disease J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 258 - 264. [Abstract] [Full Text] [PDF]

				M. M. Elahi, M. Y. Lim, R. N. Joseph, R. R. V. Dhannapuneni, and T. J. Spyt Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 1027 - 1031. [Abstract] [Full Text] [PDF]

				N. Tsunooka, K. Maeyama, Y. Hamada, H. Imagawa, S. Takano, Y. Watanabe, and K. Kawachi Bacterial translocation secondary to small intestinal mucosal ischemia during cardiopulmonary bypass. Measurement by diamine oxidase and peptidoglycan Eur. J. Cardiothorac. Surg., February 1, 2004; 25(2): 275 - 280. [Abstract] [Full Text] [PDF]

				N. B. Aydin, H. Gercekoglu, B. Aksu, V. Ozkul, T. Sener, I. Kiygil, T. Turkoglu, S. Cimen, F. Babacan, and M. Demirtas Endotoxemia in coronary artery bypass surgery: A comparison of the off-pump technique and conventional cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., April 1, 2003; 125(4): 843 - 848. [Abstract] [Full Text] [PDF]

				D. Paparella, T.M. Yau, and E. Young Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update Eur. J. Cardiothorac. Surg., February 1, 2002; 21(2): 232 - 244. [Abstract] [Full Text] [PDF]

				L. L. Lequier, H. Nikaidoh, S. R. Leonard, J. L. Bokovoy, M. L. White, P. J. Scannon, and B. P. Giroir Preoperative and Postoperative Endotoxemia in Children With Congenital Heart Disease Chest, June 1, 2000; 117(6): 1706 - 1712. [Abstract] [Full Text] [PDF]

				S. Wan, J.-L. LeClerc, C.-H. Huynh, D. Schmartz, J.-M. DeSmet, A. P.C. Yim, and J.-L. Vincent DOES STEROID PRETREATMENT INCREASE ENDOTOXIN RELEASE DURING CLINICAL CARDIOPULMONARY BYPASS? J. Thorac. Cardiovasc. Surg., May 1, 1999; 117(5): 1004 - 1008. [Abstract] [Full Text] [PDF]

				C. Baufreton, L. Intrator, P. G.M. Jansen, H. te Velthuis, P. Le Besnerais, A. Vonk, J.-P. Farcet, C. R.H. Wildevuur, and D. Y. Loisance Inflammatory response to cardiopulmonary bypass using roller or centrifugal pumps Ann. Thorac. Surg., April 1, 1999; 67(4): 972 - 977. [Abstract] [Full Text] [PDF]

				L. A. Brasil, W. J. Gomes, R. Salomao, and E. Buffolo Inflammatory response after myocardial revascularization with or without cardiopulmonary bypass Ann. Thorac. Surg., July 1, 1998; 66(1): 56 - 59. [Abstract] [Full Text] [PDF]

				C. Marie, J. Muret, C. Fitting, M.-R. Losser, D. Payen, and J.-M. Cavaillon Reduced Ex Vivo Interleukin-8 Production by Neutrophils in Septic and Nonseptic Systemic Inflammatory Response Syndrome Blood, May 1, 1998; 91(9): 3439 - 3446. [Abstract] [Full Text] [PDF]

				J. S. Steingrub Novel Insights Into the Pathogenesis and Therapy of Circulatory Shock Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 1998; 2(1): 31 - 45. [Abstract] [PDF]

				S. K Ohri Systemic inflammatory response and the splanchnic bed in cardiopulmonary bypass Perfusion, May 1, 1996; 11(3): 200 - 212. [PDF]

				M. Miyama, W. C. Dihmis, P. H. Deleuze, Y. Uozaki, S. L. Bambang, F. Pasteau, N. Rostaqui, and D. Y. Loisance The Gastrointestinal Tract: An Underestimated Organ as Demonstrated in an Experimental LVAD Pig Model Ann. Thorac. Surg., March 1, 1996; 61(3): 817 - 822. [Abstract] [Full Text]

				K. Fukae, R. Tominaga, S. Tokunaga, Y. Kawachi, T. Imaizumi, and H. Yasui THE EFFECTS OF PULSATILE AND NONPULSATILE SYSTEMIC PERFUSION ON RENAL SYMPATHETIC NERVE ACTIVITY IN ANESTHETIZED DOGS J. Thorac. Cardiovasc. Surg., February 1, 1996; 111(2): 478 - 484. [Abstract] [Full Text]

				C. T Bowles, S. K Ohri, N. Klangsuk, B. E Keogh, M. H Yacoub, and K. M Taylor Endotoxaemia detected during cardiopulmonary bypass with a modified Limulus amoebocyte lysate assay Perfusion, July 1, 1995; 10(4): 219 - 228. [Abstract] [PDF]

				J. P. A. M. Schonberger, P. A. M. Everts, and J. J. Hoffmann Systemic Blood Activation With Open and Closed Venous Reservoirs Ann. Thorac. Surg., June 1, 1995; 59(6): 1549 - 1555. [Abstract] [Full Text]

				K. A. Sotaniemi Long-Term Neurologic Outcome After Cardiac Operation Ann. Thorac. Surg., May 1, 1995; 59(5): 1336 - 1339. [Abstract] [Full Text]