JTCS Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Thomas M. Egan
Frank C. Detterbeck
Michael R. Mill
Rudy P. Lackner
Benson R. Wilcox
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Egan, T. M.
Right arrow Articles by Wilcox, B. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Egan, T. M.
Right arrow Articles by Wilcox, B. R.

J Thorac Cardiovasc Surg 1995;109:224-235
© 1995 Mosby, Inc.

CARDIAC AND PULMONARY REPLACEMENT

Improved results of lung transplantation for patients with cystic fibrosis

Thomas M. Egan, MDa (by invitation), Frank C. Detterbeck, MDa (by invitation), Michael R. Mill, MDa (by invitation), Linda J. Paradowski, MDb (by invitation), Rudy P. Lackner, MDa (by invitation), W. David Ogden, MDa (by invitation), James R. Yankaskas, MDb (by invitation), Jan H. Westerman, MDb (by invitation), Jeanette T. Thompson, BSNc (by invitation), Meredith A. Weiner, BSNc (by invitation), Ellen L. Cairns, BSNc (by invitation), Benson R. Wilcox, MDa


Chapel Hill, N.C.

Address for reprints: Thomas M. Egan, MD, 108 Burnett-Womack Building, CB #7065, Chapel Hill, NC 27599-7065.

Abstract

Patients with cystic fibrosis pose particular challenges for lung transplantation surgeons. Earlier reports from North America centers suggested that patients with cystic fibrosis were greater risk for heart-lung or isolated lung transplantation than other patients with end-stage pulmonary disease. During a 31/2 year period, 44 patients with end-stage lung disease resulting from cystic fibrosis underwent double lung transplantation at this institution. During the same interval, 18 patients with cystic fibrosis, died while waiting for a double lung transplantation. The ages of the recipients ranged from 8 to 45 years, and mean forced expiratory volume in 1 second was 21% predicted. Seven patients had Pseudomonas cepacia bacteria before transplantation. Bilateral sequential implantation with omentopexy was used in all patients. There were no operative deaths, although two patients required urgent retransplantation because of graft failure. Cardiopulmonary bypass was necessary in six procedures in five patients and was associated with an increased blood transfusion requirement, longer postoperative ventilation, and longer hospital stay. Actuarial survival rate was 85% at 1 year and 67% at 2 years. Infection was the most common cause of death within 6 months of transplantation (Pseudomonas cepacia pneumonia was the cause of death in two patients), and bronchitis obliterans was the most common cause of death after 6 months. Actuarial freedom form development of clinically significant bronchiolitis obliterans was 59% at 2 years. Results of pulmonary function tests improved substantially in survivors, with forced expiratory volume in 1 second averaging 78% predicted 2 years after transplantation. Double lung transplantation can be accomplished with acceptable morbidity and mortality in patients with cystic fibrosis.(J THORACCARDIOVASSURG1995;109-:204-35)




This article has been cited by other articles:


Home page
 Card Surg AdultHome page
A. Y. Sheikh, M. P. Pelletier, and R. C. Robbins
Heart-Lung and Lung Transplantation
Card. Surg. Adult, January 1, 2008; 3(2008): 1579 - 1608.
[Full Text]

Home page
 ChestHome page
D. Hadjiliadis
Special Considerations for Patients With Cystic Fibrosis Undergoing Lung Transplantation
Chest, April 1, 2007; 131(4): 1224 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. S. Ganesh, C. A. Rogers, R. S. Bonser, N. R. Banner, and on behalf of the steering group of the UK Cardioth
Outcome of heart-lung and bilateral sequential lung transplantation for cystic fibrosis: a UK national study
Eur. Respir. J., June 1, 2005; 25(6): 964 - 969.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
F. Venuta, S. Quattrucci, E. A. Rendina, T. De Giacomo, E. Mercadante, M. Moretti, G. Cimino, and G. F. Coloni
Improved results with lung transplantation for cystic fibrosis: a 6-year experience
Interactive CardioVascular and Thoracic Surgery, March 1, 2004; 3(1): 21 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Card Surg AdultHome page
L. B. Balsam, D. D. Yuh, R. C. Robbins, and B. A. Reitz
Heart-Lung and Lung Transplantation
Card. Surg. Adult, January 1, 2003; 2(2003): 1461 - 1490.
[Full Text]

Home page
 Eur. J. Cardiothorac. Surg.Home page
T.M. Egan, F.C. Detterbeck, M.R. Mill, M.S. Bleiweis, R. Aris, L. Paradowski, G. Retsch-Bogart, and B.S. Mueller
Long term results of lung transplantation for cystic fibrosis
Eur. J. Cardiothorac. Surg., October 1, 2002; 22(4): 602 - 609.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. A. Vricella, J. M. Karamichalis, S. Ahmad, R. C. Robbins, R. I. Whyte, and B. A. Reitz
Lung and heart-lung transplantation in patients with end-stage cystic fibrosis: the stanford experience
Ann. Thorac. Surg., July 1, 2002; 74(1): 13 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Chastre and J.-Y. Fagon
Ventilator-associated Pneumonia
Am. J. Respir. Crit. Care Med., April 1, 2002; 165(7): 867 - 903.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
T. G. Liou, F. R. Adler, B. C. Cahill, S. C. FitzSimmons, D. Huang, J. R. Hibbs, and B. C. Marshall
Survival Effect of Lung Transplantation Among Patients With Cystic Fibrosis
JAMA, December 5, 2001; 286(21): 2683 - 2689.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. CHAPARRO, J. MAURER, C. GUTIERREZ, M. KRAJDEN, C. CHAN, T. WINTON, S. KESHAVJEE, M. SCAVUZZO, E. TULLIS, M. HUTCHEON, et al.
Infection with Burkholderia cepacia in Cystic Fibrosis . Outcome Following Lung Transplantation
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 43 - 48.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. D. VIZZA, R. D. YUSEN, J. P. LYNCH, F. FEDELE, G. ALEXANDER PATTERSON, and E. P. TRULOCK
Outcome of Patients with Cystic Fibrosis Awaiting Lung Transplantation
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 819 - 825.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. W. Barlow, R. C. Robbins, M. R. Moon, O. Akindipe, J. Theodore, and B. A. Reitz
HEART-LUNG VERSUS DOUBLE-LUNG TRANSPLANTATION FOR SUPPURATIVE LUNG DISEASE
J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 466 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
K. Wiebe, Th. Wahlers, W. Harringer, H.v.d. Hardt, H. Fabel, and A. Haverich
Lung transplantation for cystic fibrosis - a single center experience over 8 years
Eur. J. Cardiothorac. Surg., August 1, 1999; 14(2): 191 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
D. Metras, L. Viard, B. Kreitmann, A. Riberi, A. Pannetier-Mille, O. Garbi, J.-Y. Marti, and P. Geigle
Lung infections in pediatric lung transplantation: experience in 49 cases
Eur. J. Cardiothorac. Surg., April 1, 1999; 15(4): 490 - 495.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. F. Doershuk and R. C. Stern
Timing of Referral for Lung Transplantation for Cystic Fibrosis: Overemphasis on FEV1 May Adversely Affect Overall Survival
Chest, March 1, 1999; 115(3): 782 - 787.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. N. HUSAIN, M. T. SIDDIQUI, E. W. HOLMES, A. J. CHANDRASEKHAR, M. MCCABE, R. RADVANY, and E. R. GARRITY Jr.
Analysis of Risk Factors for the Development of Bronchiolitis Obliterans Syndrome
Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 829 - 833.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
T. M. Egan, F. C. Detterbeck, M. R. Mill, K. K. Gott, J. B. Rea, J. McSweeney, R. M. Aris, and L. J. Paradowski
Lung transplantation for cystic fibrosis: effective and durable therapy in a high-risk group
Ann. Thorac. Surg., August 1, 1998; 66(2): 337 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Novick, L. W. Stitt, K. Al-Kattan, W. Klepetko, H.-J. Schafers, J.-P. Duchatelle, A. Khaghani, R. L. Hardesty, G. A. Patterson, and M. H. Yacoub
Pulmonary Retransplantation: Predictors of Graft Function and Survival in 230 Patients
Ann. Thorac. Surg., January 1, 1998; 65(1): 227 - 234.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
R. J. Novick, L. Stitt, H.-J. Schafers, B. Andreassian, J.-P. Duchatelle, W. Klepetko, R. L. Hardesty, A. Frost, and G. A. Patterson
PULMONARY RETRANSPLANTATION: DOES THE INDICATION FOR OPERATION INFLUENCE POSTOPERATIVE LUNG FUNCTION?
J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1504 - 1514.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
R. J. Novick, H.-J. Schafers, L. Stitt, B. Andreassian, W. Klepetko, R. L. Hardesty, A. Frost, and G. A. Patterson
Seventy-two Pulmonary Retransplantations for Obliterative Bronchiolitis: Predictors of Survival
Ann. Thorac. Surg., July 1, 1995; 60(1): 111 - 116.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1995 by The American Association for Thoracic Surgery.