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J Thorac Cardiovasc Surg 1995;109:242-248
© 1995 Mosby, Inc.

CARDIOPULMONARY BYPASS, MYOCARDIAL MANAGEMENT, AND SUPPORT TECHNIQUES

Resuscitative retrograde blood cardioplegiaAre amino acids or continuous warm techniques necessary?

New York, N.Y.

From the Division of Cardiothoracic Surgery, Department of Surgery, New York University Medical Center, New York, N.Y.

Address for reprints: Aubrey C. Galloway, MD, Director of Surgical Research, New York University Medical Center, 530 First Ave., Suite 6D, New York, NY 10016.

Abstract

This experiment was designed to determine the relative degree of cardiac functional recovery provided by various forms of resuscitative retrograde blood cardioplegia after global ischemic injuy. Twenty-four dogs were subjected to 20 minutes of normothermic global ischemia followed by 60 minutes of cardioplegic arrest by one of three methods: 1, standard cold blood cardialgia with a cold terminal dose (n = 8); 2, aspartate-glutamate–enhanced blood with warm induction and terminal enhancement (n = 8); and group 3, countinous warm blood cardioplegia (n = 8). Sonomichrometry was used to analyze left ventricular function for maximal elastance and preload recruitable stroke work area. Data were recorded at baseline and preload recruitable stroke work area, but not of maximal elastance, after reperfusion of ischemic differences were detectable among the groups after 60 minutes of unloaded reperfusion. Neither amino acid enchancement nor continuous warm cardioplegia offered a significant advantage in functional recovery over the standard method of cold cardioplegia reperfusion.(J THORACCARDIOVACSURG1995;109:242-8)

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