| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 1995;109:409-418
© 1995 Mosby, Inc.
CARDIOPULMONARY BYPASS, |
Cleveland, Ohio.
Cleveland, Ohio
From the Departments of Thoracic and Cardiovascular Surgery, Cardiology, Cardiothoracic Anesthesia, and Biostatistics and Epidemiology, Cleveland Clinic Foundation, Cleveland, Ohio.
Address for reprints: Patrick M. McCarthy, MD, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, 9500 Euclid Ave., F-25, Cleveland, OH 44195.
Abstract
To evaluate hemodynamic effectiveness and physiologic changes on the HeartMate 1000 IP left ventricular assist device (Thermo Cardiosystems, Inc., Woburn, Mass.), we studied 25 patients undergoing bridge to heart transplantation (35 to 63 years old, mean 50 years). All were receiving inotropic agents before left ventricular assist device implantation, 21 (84%) were supported with a balloon pump, and 7 (28%) were supported by extracorporeal membrane oxygenation. Six patients died, primarily of right ventricular dysfunction and multiple organ failure. Nineteen (76%) were rehabilitated, received a donor heart, and were discharged (100% survival after transplantation). Pretransplantation duration of support averaged 76 days (22 to 153 days). No thromboembolic events occurred in more than 1500 patient-days of support with only antiplatelet medications. Significant hemodynamic improvement was measured (before implantation to before explantation) in cardiac index (1.7±0.3 to 3.1±0.8 L/min per square meter; P < 0.001), left atrial pressure (23.7±7 to 9±7.5mm Hg; p < 0.001), pulmonary artery pressure, pulmonary vascular resistance, and right ventricular volumes and ejection fraction. Both creatinine and blood urea nitrogen levels were significantly higher before implantation in patients who died while receiving support. Renal and liver function returned to normal before transplantation. We conclude that support with the HeartMate device improved hemodynamic and subsystem function before transplantation. Long-term support with the HeartMate device a realistic alternative to medical therapy. (J THORAC CARDIOVASC SURG1995; 109: 409-18)
This article has been cited by other articles:
|
|
 |
|
  V. Kartha, W. Gomez, B. Wu, and K. Tremper Laparoscopic cholecystectomy in a patient with an implantable left ventricular assist device Br. J. Anaesth., May 1, 2008; 100(5): 652 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mancini and D. Burkhoff Mechanical Device-Based Methods of Managing and Treating Heart Failure Circulation, July 19, 2005; 112(3): 438 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rinaldi, F. Pagani, F. Gazzoli, A. Alloni, D. Ricci, and M. Vigano Left ventricular assistance from bridge to transplantation to destination therapy. The Pavia experience Eur. Heart J. Suppl., November 1, 2004; 6(suppl_F): F81 - F86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Gammie, L. B. Edwards, B. P. Griffith, R. N. Pierson III, and L. Tsao Optimal timing of cardiac transplantation after ventricular assist device implantation J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1789 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Hall, S. Grindle, X. Han, D. Fermin, S. Park, Y. Chen, R. J. Bache, A. Mariash, Z. Guan, S. Ormaza, et al. Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks Physiol Genomics, May 19, 2004; 17(3): 283 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Morgan, R. John, B. J. Lee, M. C. Oz, and Y. Naka Is severe right ventricular failure in left ventricular assist device recipients a risk factor for unsuccessful bridging to transplant and post-transplant mortality Ann. Thorac. Surg., March 1, 2004; 77(3): 859 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Letsou, T. J. Myers, I. D. Gregoric, R. Delgado, N. Shah, K. Robertson, B. Radovancevic, and O. H. Frazier Continuous axial-flow left ventricular assist device (Jarvik 2000) maintains kidney and liver perfusion for up to 6 months Ann. Thorac. Surg., October 1, 2003; 76(4): 1167 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. N. Khot, M. Mishra, M. H. Yamani, N. G. Smedira, E. Paganini, M. Yeager, T. Buda, P. M. McCarthy, J. B. Young, and R. C. Starling Severe renal dysfunction complicating cardiogenic shock is not a contraindication to mechanical support as a bridge to cardiac transplantation J. Am. Coll. Cardiol., February 5, 2003; 41(3): 381 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Navia, P. M. McCarthy, K. J. Hoercher, N. G. Smedira, M. K. Banbury, and E. H. Blackstone Do left ventricular assist device (LVAD) bridge-to-transplantation outcomes predict the results of permanent LVAD implantation? Ann. Thorac. Surg., December 1, 2002; 74(6): 2051 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Grady, P. Meyer, A. Mattea, D. Dressler, S. Ormaza, C. White-Williams, S. Chillcott, A. Kaan, B. Todd, A. Loo, et al. Predictors of Quality of Life at 1 Month After Implantation of a Left Ventricular Assist Device Am. J. Crit. Care., July 1, 2002; 11(4): 345 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. McCarthy Implantable left ventricular assist device bridge-to-transplantation: natural selection, or is this the natural selection? J. Am. Coll. Cardiol., April 17, 2002; 39(8): 1255 - 1257. [Full Text] [PDF]
|
|
|
|
 |
|
 A K Mahmood, J M Courtney, S Westaby, M Akdis, and H Reul Critical review of current left ventricular assist devices Perfusion, September 1, 2000; 15(5): 399 - 420. [PDF]
|
|
|
|
 |
|
 P. Mohacsi, M. C. Deng, R. Murphy, C.-H. Bergh, E. Gronda, M. Komajda, R. Pacher, J. Spinar, K. Swedberg, and J. F. Cleland Implantable left ventricular assist systems (LVAS): Recent results. A report from a series of meetings sponsored by the Study Group on Advanced Heart Failure of the Working Group on Heart Failure Eur J Heart Fail, March 1, 2000; 2(1): 13 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fukamachi, P. M. McCarthy, N. G. Smedira, R. L. Vargo, R. C. Starling, and J. B. Young Preoperative risk factors for right ventricular failure after implantable left ventricular assist device insertion Ann. Thorac. Surg., December 1, 1999; 68(6): 2181 - 2184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kasirajan, N. G. Smedira, J. Perl II, and P. M. McCarthy Cerebral embolism associated with left ventricular assist device support and successful therapy with intraarterial urokinase Ann. Thorac. Surg., April 1, 1999; 67(4): 1148 - 1150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Reinhartz, D. J. Farrar, J. H. Hershon, G. J. Avery Jr, E. A. Haeusslein, and J. D. Hill Importance of preoperative liver function as a predictor of survival in patients supported with Thoratec ventricular assist devices as a bridge to transplantation J. Thorac. Cardiovasc. Surg., October 1, 1998; 116(4): 633 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. E. Pae Jr, J. M. Anderson, E. H. Blackstone, H. S. Boroevetz, A. Ciarkowski, J. G. Copeland III, M. R. Costanzo-Nordin, K. Daase, M. A. Dew, M. J. Domanski, et al. Bethesda conference: conference for the design of clinical trials to study circulatory support devices for chronic heart failure Ann. Thorac. Surg., October 1, 1998; 66(4): 1452 - 1465. [Full Text] [PDF]
|
|
|
|
|
|
D. M. Kulick, R. M. Bolman III, C. T. Salerno, A. J. Bank, and S. J. Park Management of recurrent ventricular tachycardia with ventricular assist device placement Ann. Thorac. Surg., August 1, 1998; 66(2): 571 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Koul, J.-O. Solem, S. Steen, H. Casimir-Ahn, H. Granfeldt, and U. J. Lonn HeartMate Left Ventricular Assist Device as Bridge to Heart Transplantation Ann. Thorac. Surg., June 1, 1998; 65(6): 1625 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. McCarthy, J. B. Young, N. G. Smedira, R. E. Hobbs, R. L. Vargo, and R. C. Starling Permanent Mechanical Circulatory Support With an Implantable Left Ventricular Assist Device Ann. Thorac. Surg., May 1, 1997; 63(5): 1458 - 1461. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Vigano, S. Scuri, F. Cobelli, C. Opasich, F. M. Pagani, G. Minzioni, L. Martinelli, L. Tavazi, and M. Vigano Staged discharge out of hospital of the Novacor left ventricular assist system (LVAS) recipients Eur. J. Cardiothorac. Surg., April 1, 1997; 11(suppl): S45 - S50. [Abstract] [PDF]
|
|
|
|
|
|
K. B. James, P. M. McCarthy, S. Jaalouk, E. L. Bravo, A. Betkowski, J. D. Thomas, S. Nakatani, and F. M. Fouad-Tarazi Plasma Volume and Its Regulatory Factors in Congestive Heart Failure After Implantation of Long-term Left Ventricular Assist Devices Circulation, April 15, 1996; 93(8): 1515 - 1519. [Abstract] [Full Text]
|
|
|
|
|
|
R. L. Kormos, T. A. Gasior, A. Kawai, S. M. Pham, S. Murali, B. G. Hattler, and B. P. Griffith TRANSPLANT CANDIDATE'S CLINICAL STATUS RATHER THAN RIGHT VENTRICULAR FUNCTION DEFINES NEED FOR UNIVENTRICULAR VERSUS BIVENTRICULAR SUPPORT J. Thorac. Cardiovasc. Surg., April 1, 1996; 111(4): 773 - 783. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
