HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Walter E. Pae William S. Pierce Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kawaguchi, O. Articles by Pierce, W. S. Search for Related Content PubMed PubMed Citation Articles by Kawaguchi, O. Articles by Pierce, W. S.

J Thorac Cardiovasc Surg 1995;109:780-786
© 1995 Mosby, Inc.

CARDIOPULMONARY BYPASS, MYOCARDIAL MANAGEMENT, AND SUPPORT TECHNIQUES

Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function

Hershey, Pa.

From the Division of Cardiothoracic Surgery, Department of Surgery, College of Medicine, and The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pa.

Received for publication March 10, 1994. Accepted for publication July 28, 1994. Address for reprints: William S. Pierce, MD, P.O. Box 850, Department of Surgery, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033.

Abstract

This study assessed whether the end-systolic pressure-volume relationship obtained without any interventions during pulsatile left ventricular bypass adequately represents native heart function. In 11 anesthetized Holstein calves, left ventricular pressure was measured with a micromanometer while left ventricular volume was simultaneously calculated from orthogonal left ventricular diameters measured with ultrasonic dimension transducers. End-systolic pressure and volume data were subjected to linear regression analysis to achieve an end-systolic pressure-volume relationship. Data from both caval occlusions and aortic occlusion were used for the control end-systolic pressure-volume relationship (median r = 0.941, slope = 7.4 ± 0.8 mm Hg per milliliter per 100 gm left ventricular weight; mean ± standard error of the mean). During left atrial-aortic bypass with a Pierce-Donachy pneumatic assist pump in the asynchronous mode, the end-systolic pressure-volume relationships were obtained without interventions to change ventricular loading conditions. During maximal ventricular unloading during full to empty pumping, termed 100%, the resulting narrow range of pressure and volume data did not yield highly linear end-systolic pressure-volume relationships (median r = 0.669, slope = 4.9 ± 0.9 mm Hg per milliliter per 100 gm left ventricular weight). However, at reduced rates off pumping, the end-systolic pressure-volume relationships were considerably linear (80%, median r = 0.819; 60%, median r = 0.868; 40%, median r = 0.899). Slopes did not significantly differ from control values (80%, 6.9 ± 1.1; 60%, 8.2 ± 1.1; 40%, 7.8 ± 1.1). The end-systolic pressure-volume relationship obtained without exogenous load changes during asynchronous, pulsatile left ventricular bypass represents native left ventricular systolic function. (J THORAC CARDIOVASC SURG 1995;109:780-6)

This article has been cited by other articles:

				Y. Uozaki, A. Murakami, H. Asanoi, S. Ishizaka, and T. Misaki Effect of Assisted Circulation on Left Ventricular Performance in a Canine Model Ann. Thorac. Surg., March 1, 1998; 65(3): 663 - 666. [Abstract] [Full Text] [PDF]