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The Journal of Thoracic and Cardiovascular Surgery, Vol 109, Issue 5 905-909, Copyright © 1995 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

NOTE: The fulltext of this article is not available online.

Modulation of alloreactivity in transplant recipients by phenotypic manipulation of donor endothelium

R. L. Quigley, S. S. Switzer, T. A. Victor, R. A. Goldschmidt, M. H. Salinger, C. E. Arentzen, J. C. Alexander and R. W. Anderson
Department of Surgery, Northwestern University-Evanston Hospital, IL 60201, USA.

Phenotypic manipulation of allograft endothelium to reduce immunogenicity would have a significant impact on transplantation. In this study we have demonstrated that random seeding of a heart allograft with endothelium, of host origin, not only promotes long-term survival, but reduces the requirement for pharmacologic immunosuppression. We propose that this simple technology could easily be extrapolated to the clinical arena where hypothermia and preservation solutions have allowed allografts to remain ex vivo for extended periods.