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The Journal of Thoracic and Cardiovascular Surgery, Vol 109, Issue 5 910-917, Copyright © 1995 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

NOTE: The fulltext of this article is not available online.

Short-course immunosuppression after tracheal allotransplantation in dogs

R. Nakanishi, K. Yasumoto and T. Shirakusa
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

It is desirable to minimize immunosuppression after allotransplantation. We examined the usefulness of a short course of immunosuppression after tracheal allotransplantation in 35 dogs. Five animals with six-ring tracheal autografts served as controls (group I, n = 5). Thirty animals with six-ring tracheal allografts were randomly classified into five groups as follows: no immunosuppression (group II, n = 6), azathioprine for only 1 postoperative week (group III, n = 7), azathioprine for 2 postoperative weeks (group IV, n = 7), azathioprine for 3 postoperative weeks (group V, n = 5), and mizoribine for 3 postoperative weeks (group VI, n = 5). All allografts in groups II through VI sustained rejection, but there was no difference in mononuclear cell infiltration of the grafts among the groups. The only grafts with long-term viability were those in groups I and VI, as demonstrated by graft patency and epithelialization. We conclude that immunosuppression with mizoribine for only a short course after transplantation may allow long-term viability of tracheal allografts.

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