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J Thorac Cardiovasc Surg 1995;109:1218-1224
© 1995 Mosby, Inc.

SURGERY FOR CONGENITAL HEART DISEASE

Pulmonary vascular resistance during exercise late after repair of large ventricular septal defectsRelation to age at the time of repair

Osaka, Japan

From the First Department of Surgery, Osaka University Medical School, Osaka, Japan.

Received for publication Jan. 11, 1994. Accepted for publication Oct. 10, 1994. Address for reprints: Yasuhisa Shimazaki, MD, First Department of Surgery, Osaka University Medical School, 2-2, Yamadaoka, Suita-city, Osaka, 565, Japan.

Abstract

Postoperative pulmonary artery pressure and resistance were assessed during exercise in 32 patients late after repair of large ventricular septal defect with pulmonary hypertension. Nineteen patients had a preoperative pulmonary-to-systemic resistance ratio of between 0.15 and 0.50 (group 1) and 13 had a ratio between 0.50 and 0.96 (group 2). Age at the time of operation was 0.9 to 13.0 years (4.6 ± 3.6) in group 1 and 0.8 to 15.8 years (4.3 ± 4.2) in group 2. Age at the time of restudy was 9 to 21 years (14.5 ± 3.0) in group 1 and 9 to 22 years (13.5 ± 4.1) in group 2. Pulmonary artery pressure was measured in the supine position at rest and during exercise, as were the measurements underlying the calculations of pulmonary vascular resistance. Mean pulmonary artery pressure was 13 to 21 mm Hg (17 ± 2) and 10 to 26 mm Hg (20 ± 5) in groups 1 and 2, respectively, at rest, and this increased to 17 to 27 mm Hg (22 ± 3) and 14 to 39 mm Hg (27 ± 7) in groups 1 and 2, respectively, during exercise (p < 0.05). Pulmonary vascular resistance was 0.51 to 3.40 U · m²(1.93 ± 0.63) and 0.79 to 3.31 U · m² (2.05 ± 0.65) in groups 1 and 2 at rest. It was 0.58 to 2.24 U m²(1.36 ± 0.57) and 0.81 to 3.85 U m²(2.18 ± 0.97) in groups 1 and 2 during exercise (p < 0.01). Postoperative pulmonary vascular resistance during exercise correlated well with age at the time of repair in both groups (r = 0.65, p < 0.05 in group 1; r = 0.86, p < 0.001 in group 2). These data suggest that 85% of patients with a preoperative pulmonary-to-systemic resistance ratio of between 0.15 and 0.50 would have normal pulmonary vascular resistance during exercise when operated on at younger than 3.8 years old and 85% of those with a preoperative pulmonary-to-systemic resistance ratio of more than 0.50 would have normal pulmonary vascular resistance during exercise when operated on at younger than 1.1 years. (J THORAC CARDIOVASC SURG1995;109:1218-24)

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