HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Cary H. Meyers Theodore C. Koutlas David S. Peterseim David C. Sabiston, Jr. Peter Van Trigt Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by D'Amico, T. A. Articles by Schwinn, D. A. Search for Related Content PubMed PubMed Citation Articles by D'Amico, T. A. Articles by Schwinn, D. A.

J Thorac Cardiovasc Surg 1995;110:746-0751
© 1995 Mosby, Inc.

CARDIAC AND PULMONARY REPLACEMENT

Desensitization of myocardial ß-adrenergic receptors and deterioration of left ventricular function after brain death

Durham, N.C.

Supported in part by American Heart Association Grants in Aid No. 92009270 (D. A. S.) and No. 90011230 (P. V. T).

Received for publication Nov. 18, 1994. Accepted for publication Feb. 3, 1995. Address for reprints: Thomas A. D'Amico, MD, Duke University Medical Center, Box 31013, Durham, NC 27710.

Abstract

Brain death often results in a series of hemodynamic alterations that complicate the treatment of potential organ donors before transplantation. The deterioration of myocardial performance after brain death has been described; however, the pathophysiologic process of the myocardial dysfunction that occurs after brain death has not been elucidated. This study was designed to analyze the function of the myocardial ß-adrenergic receptor and the development of left ventricular dysfunction in a porcine model of experimental brain death. Analysis of the ß-receptor included determination of receptor density and adenylate cyclase activity after stimulation independently at the receptor protein, the G protein, and the adenylate cyclase moiety. Myocardial ß-receptor density did not change after the induction of brain death. A decrease in stimulated adenylate cyclase activity was observed within the first hour after brain death at the level of the ß-receptor, the G protein, and the adenylate cyclase moiety, which suggests the occurrence of rapid desensitization of ß-receptor function. Significant deterioration of myocardial performance also occurred within the first hour after brain death, represented by a decrease in preloadrecruitable stroke work compared with the baseline value. The deterioration of myocardial performance after brain death correlates temporally with desensitization of the myocardial ß-receptor signal transduction system. The mechanism of impairment appears to be localized to the adenylate cyclase moiety itself. (J THORACCARDIOVASCSURG95;110: 51)

This article has been cited by other articles:

				P. K. Pandalai, K. M. McLean, C. F. Bulcao, J. Y. Duffy, K. M. D'Souza, W. H. Merrill, J. M. Pearl, and S. A. Akhter Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death. J. Thorac. Cardiovasc. Surg., April 1, 2008; 135(4): 792 - 798. [Abstract] [Full Text] [PDF]

				S. D. Shemie, H. Ross, J. Pagliarello, A. J. Baker, P. D. Greig, T. Brand, S. Cockfield, S. Keshavjee, P. Nickerson, V. Rao, et al. Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential. Can. Med. Assoc. J., March 14, 2006; 174(6): S13 - S32. [Full Text] [PDF]

				S. D. Shemie, H. Ross, J. Pagliarello, A. J. Baker, P. D. Greig, T. Brand, S. Cockfield, S. Keshavjee, P. Nickerson, V. Rao, et al. La prise en charge des donneurs d'organes au Canada : recommandations du forum Optimiser le maintien du donneur afin d'accroitre le nombre d'organes admissibles pour la transplantation Can. Med. Assoc. J., March 14, 2006; 174(6): SF14 - SF32. [Full Text] [PDF]

				P. K. Pandalai, J. M. Lyons, J. Y. Duffy, K. M. McLean, C. J. Wagner, W. H. Merrill, J. M. Pearl, and S. A. Akhter Role of the {beta}-adrenergic receptor kinase in myocardial dysfunction after brain death J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 1183 - 1189. [Abstract] [Full Text] [PDF]

				F. Farhat, D. Loisance, J.-P. Garnier, and M. Kirsch Norepinephrine release after acute brain death abolishes the cardioprotective effects of ischemic preconditioning in rabbit Eur. J. Cardiothorac. Surg., March 1, 2001; 19(3): 313 - 320. [Abstract] [Full Text] [PDF]