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J Thorac Cardiovasc Surg 1995;110:1642-1648
© 1995 Mosby, Inc.

CARDIOPULMONARY BYPASS, MYOCARDIAL MANAGEMENT, AND SUPPORT TECHNIQUES

ZINC SUPPLEMENTATION ENHANCES THE EFFECTIVENESS OF ST. THOMAS' HOSPITAL NO. 2 CARDIOPLEGIC SOLUTION IN AN IN VITRO MODEL OF HYPOTHERMIC CARDIAC ARREST

Manhasset, N.Y.

Supported in part by National Institutes of Health grant HL45534 and Research Funds from the Division of Cardiothoracic Surgery.

Received for publication Nov. 2, 1994. Accepted for publication Feb. 22, 1995. Address for reprints: Saul R. Powell, PhD, Boas-Marks BioMedical Science Research Building, North Shore University Hospital, 350 Community Dr., Manhasset, NY 11030.

Abstract

The present study was done to assess the effectiveness of a zinc–supplemented cardioplegic solution in an in vitro model of hypothermic arrest. Isolated hearts were perfused in the nonworking mode. All hearts were subjected to 2 hours of hypothermic arrest, at 10°C, followed by 60 minutes of recovery. In protocol 1, arrest was initiated with infusion of cardioplegic solution with or without 30µmol/L zinc for 5 minutes, which was then reinfused for 5 minutes every 15 minutes during arrest. In protocol 2, arrest was initiated with infusion of cardioplegic solution with or without 40µmol/L zinc for 10 minutes. Cardioplegic solution (without zinc) was then reinfused for 5 minutes before the hearts were rewarmed. In protocol 1 hearts, peak postischemic left ventricular developed systolic pressure was 106±5 mm Hg and 80±3 mm Hg in zinc–treated versus control hearts, respectively (p <0.05 by repeated–measures analysis of variance). In protocol 2 hearts, recovery of postischemic left ventricular developed systolic pressure peaked at 74±4 mm Hg and 46±8 mm Hg in zinc–treated and control hearts, respectively (p <0.05, repeated–measures analysis of variance). Similar effects were observed for the left ventricular rate of relaxation (p <0.05, repeated–measures analysis of variance). Except for some minor effects, lactate dehydrogenase release was not affected by zinc supplementation. The present study demonstrates that zinc supplementation further enhances the normally observed preservation of postarrest cardiac function and suggests possible clinical utility for this metal as an additive to standard crystalloid cardioplegic solutions. (J THORAC CARDIOVASC SURG 1995; 110:1642-8)

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