JTCS Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fukai, I.
Right arrow Articles by Eimoto, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukai, I.
Right arrow Articles by Eimoto, T.

J Thorac Cardiovasc Surg 1995;110:1670-1675
© 1995 Mosby, Inc.

GENERAL THORACIC SURGERY

DIFFERENTIAL DIAGNOSIS OF THYMIC CARCINOMA AND LUNG CARCINOMA WITH THE USE OF ANTIBODIES TO CYTOKERATINS

Ichiro Fukai, MDa, Akira Masaoka, MD, PhDa, Takahiko Hashimoto, MDa, Yosuke Yamakawa, MDa, Hiroshi Niwa, MDa, Masanobu Kiriyama, MDa, Tadaaki Eimoto, MD, PhDb


Nagoya, Japan

Dr. Masaoka is organizer of the project "Function of Thymoma," which is supported by a grant from the Ministry of Health and Welfare of Japan.

Received for publication Nov. 18, 1994. Accepted for publication March 3, 1995. Address for reprints: Ichiro Fukai, MD, Second Department of Surgery, Nagoya City University Medical School, Mizuho-ku, Nagoya, Japan.

Abstract

There are few specific pathologic findings that can be relied on to distinguish primary thymic carcinomas from lung carcinomas with mediastinal extension or showing metastasis to the anterior mediastinum. The immunohistochemical reactivity on frozen sections of thymic carcinomas and lung carcinomas, which are histologically similar to each other, was examined with the use of monoclonal antibodies to cytokeratins 7 and 13. Among keratinizing squamous cell carcinomas, all thymic carcinomas reacted with antibody specific for cytokeratin 7 (9/9, 100%), whereas no staining reaction was seen in lung carcinomas (0/5, 0%) (p <0.01). This finding can be used as a diagnostic aid in primary thymic keratinizing squamous cell carcinomas to expedite treatment and prognosis. Cytokeratin 7 and cytokeratin 13 monoclonal antibodies reacted with almost all cases of thymic carcinoma. Applications of monoclonal antibodies specific for certain cytokeratins, especially 7 and 13, may be helpful in the diagnosis of other subtypes of thymic carcinomas. (J THORAC CARDIOVASC SURG 1995;110:1670-5)




This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
J. Nakajima, S. Takamoto, T. Oka, M. Tanaka, E. Takeuchi, and T. Murakawa
Flow cytometric analysis of lymphoid cells in thymic epithelial neoplasms
Eur. J. Cardiothorac. Surg., September 1, 2000; 18(3): 287 - 292.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1995 by The American Association for Thoracic Surgery.