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J Thorac Cardiovasc Surg 1996;112:281-286
© 1996 Mosby, Inc.

SURGERY FOR ACQUIRED HEART DISEASE

DONOR-SPECIFIC CELLULAR IMMUNE RESPONSE AGAINST HUMAN CARDIAC VALVE ALLOGRAFTS

Franciska Hoekstra, MDa, Christiaan Knoop, BSca, Len Vaessen, BSca, Claas Wassenaar, MDb, Nicolet Jutte, PhDa, Egbert Bos, MDc, Ad Bogers, MDc, Willem Weimar, MDa

Received for publication August 14, 1995 Revisions requested Oct. 24, 1995; revisions received Jan. 16, 1996 Accepted for publication Jan. 18, 1996. Address for reprints: F. M. E. Hoekstra, MD, Department of Internal Medicine I, Room Bd 293, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Abstract

We studied the presence of donor-specific T lymphocytes in explanted human cardiac valve allografts in vivo. From five of seven explants we propagated lymphocyte cultures in an interleukin-2 conditioned medium. Phenotyping revealed the presence of T-cell receptors in more than 95% of the lymphocytes obtained in each culture. Donor-specific cytotoxicity was demonstrated in three patients with known HLA status of the donor. Cytotoxicity was directed against only HLA class I in one patient, and against class I and/or class II in the others. These results indicate that donor-specific cellular reactivity can be induced by transplantation of human cardiac valve allografts.(J THORACCARDIOVASCSURG1996;112:281-6)




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