HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Eldad Erez Bernardo A. Vidne Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hasdai, D. Articles by Vidne, B. A. Search for Related Content PubMed PubMed Citation Articles by Hasdai, D. Articles by Vidne, B. A.

J Thorac Cardiovasc Surg 1996;112:531-536
© 1996 Mosby, Inc.

CARDIOPULMONARY BYPASS, MYOCARDIAL MANAGEMENT, AND SUPPORT TECHNIQUES

IS THE HEART A SOURCE FOR ELEVATED CIRCULATING ENDOTHELIN LEVELS DURING AORTA—CORONARY ARTERY BYPASS GRAFTING SURGERY IN HUMAN BEINGS?

Received for publication July 13, 1995 Revisions requested Sept. 13, 1995; revisions received Dec. 29, 1995 Accepted for publication Jan. 15, 1996. Address for reprints: Samuel Sclarovsky, MD, Department of Cardiology, Beilinson Medical Center, Petah-Tikva, Israel 49100.

Abstract

Reports have shown increased systemic levels of endothelins during coronary artery bypass grafting in human beings. It was not known whether increased endothelin levels during coronary artery bypass grafting reflect a general systemic response to the surgical procedure or increased myocardial production of endothelins in response to ischemia and reperfusion. We therefore measured endothelin levels in the right atrium and proximal aorta of 15 patients undergoing coronary artery bypass grafting for anginal syndrome immediately before aortic crossclamping and again after cessation of cardiopulmonary bypass. In five patients, we also measured coronary sinus levels of endothelins during cardiopulmonary bypass circulation. We found that endothelin levels were elevated throughout the surgical procedure. Right atrial endothelin levels were significantly elevated after cessation of cardiopulmonary bypass circulation with respect to values immediately before aortic crossclamping (11.1 ± 3.1 vs 14.2 ± 3.7 pg/ml, p = 0.008), whereas endothelin levels in the proximal aorta did not rise significantly (10.5 ± 2.3 vs 11.6 ± 2.4 pg/ml, p > 0.5). Coronary sinus endothelin levels tended to decline temporarily during cardiopulmonary bypass circulation (11.1 ± 2.1 pg/ml before aortic crossclamping, 7.9 ± 1.9 1 minute after release of aortic crossclamp, and 9.9 ± 2.1 pg/ml after release of partial aortic crossclamping, p = 0.06). We conclude that the rise in right atrial endothelin levels during coronary artery bypass grafting reflects systemic production and secretion of endothelins, probably by vasculature or organs distal to the proximal aorta, and is not the result of increased myocardial production and secretion of endothelins. (J THORACCARDIOVASCSURG1996;112:531-6)

This article has been cited by other articles:

				U. Lockowandt and A. Franco-Cereceda Is there a role for endothelin-blockade early after coronary artery bypass grafting? Ann. Thorac. Surg., September 1, 2002; 74(3): 727 - 732. [Abstract] [Full Text] [PDF]

				U. Lockowandt, S. Bjessmo, T. Ivert, and A. Franco-Cereceda Plasma levels and vascular effects of endothelin and big endothelin in patients with stable and unstable angina pectoris undergoing coronary bypass grafting Eur. J. Cardiothorac. Surg., February 1, 2002; 21(2): 218 - 223. [Abstract] [Full Text] [PDF]

				H. A. Hennein Inflammation After Cardiopulmonary Bypass: Therapy for the Postpump Syndrome Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 236 - 255. [Abstract] [PDF]

				C. A. Walker, S. C. Baicu, A. T. Goldberg, C. E. Widener, D. J. Fary, D. K. Almany, A. Ergul, F. A. Crawford Jr, and F. G. Spinale Temporal endothelin dynamics of the myocardial interstitium and systemic circulation in cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., November 1, 2000; 120(5): 864 - 871. [Abstract] [Full Text] [PDF]

				A. T. Goldberg, B. R. Bond, R. Mukherjee, R. B. New, J. L. Zellner, F. A. Crawford Jr, and F. G. Spinale Endothelin receptor pathway in human left ventricular myocytes: relation to contractility Ann. Thorac. Surg., March 1, 2000; 69(3): 711 - 715. [Abstract] [Full Text] [PDF]

				J. R. Sadaba, K. Mathew, C. M. Munsch, and D. J. Beech Vasorelaxant properties of nicorandil on human radial artery Eur. J. Cardiothorac. Surg., March 1, 2000; 17(3): 319 - 324. [Abstract] [Full Text] [PDF]