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J Thorac Cardiovasc Surg 1996;112:1600-1609
© 1996 Mosby, Inc.

SURGERY FOR CONGENITAL HEART DISEASE

PULMONARY HYPERTENSION AFTER OPERATIONS FOR CONGENITAL HEART DISEASE: ANALYSIS OF RISK FACTORS AND MANAGEMENT

From the Section of Cardiothoracic Surgery, James W. Riley Hospital for Children and Indiana University Medical Center, Indianapolis, Ind.

Received for publication May 6, 1996 Revisions requested June 26, 1996; revisions received July 29, 1996 Accepted for publication July 31, 1996. Address for reprints: Ko Bando, MD, Section of Cardiothoracic Surgery, Indiana University Medical Center, 545 Barnhill Dr., EM 215, Indianapolis, IN 46202-5123.

Abstract

Background: Management of pulmonary hypertension, a potentially fatal complication of operations to correct congenital heart disease, has evolved through the last 15 years. Monitoring of pulmonary arterial pressure and mixed venous saturation became available, and prophylactic use of-blockers and other vasodilators increased. This study examines risk factors for morbidity and mortality from pulmonary hypertension after operations to correct congenital heart disease and evaluates the impact of management changes on outcomes.
Methods: By means of multivariable logistic regression analysis, 880 high-risk patients with congenital heart disease (of 2484 patients undergoing cardiopulmonary bypass between January 1980 and December 1994) were analyzed to determine which were at risk for postoperative pulmonary hypertension and its associated morbidity and mortality.
Results: Patients with atrioventricular canal (n = 182), truncus arteriosus (n = 47), total anomalous pulmonary venous connection (n = 90), transposition of great arteries (n = 97), hypoplastic left heart syndrome (n = 50), and ventricular septal defect (n = 414) demonstrated a higher risk of postoperative pulmonary hypertension. By multivariable logistic regression, preoperative pulmonary hypertension (p < 0.0001), absence of mixed venous saturation monitoring (p < 0.0001), and absence of prophylactic-blockade (p = 0.0004) significantly increased postoperative pulmonary hypertension. Preoperative pulmonary hypertension (p < 0.001) and absence of prophylactic-blockers (p = 0.0004) were significant risk factors for in-hospital death related to pulmonary hypertension. Repair at older age (except in the case of total anomalous pulmonary venous connection) was a significant risk for postoperative pulmonary hypertension (p = 0.03).
Conclusion: Mixed venous saturation monitoring and-receptor blockade reduced the incidence of pulmonary hypertension after operations for congenital heart disease. Early definitive repair reduced morbidity and mortality from postoperative pulmonary hypertension. (J THORACCARDIOVASCSURG1996;112:1600-9)

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