HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Lester R. Sauvage Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kouchi, Y. Articles by Sauvage, L. R. Search for Related Content PubMed PubMed Citation Articles by Kouchi, Y. Articles by Sauvage, L. R.

J Thorac Cardiovasc Surg 1997;113:114-120
© 1997 Mosby, Inc.

SURGERY FOR ACQUIRED HEART DISEASE

EFFECT OF ALTERED BLOOD FLOW ON THE CALIBER AND MORPHOLOGY OF THE INTERNAL THORACIC ARTERY IN THE DOG

Received for publication Dec. 26, 1995 Revisions requested Feb. 6, 1996 Revisions received June 28, 1996 Accepted for publication July 8, 1996 Address for reprints: Lester R. Sauvage, MD, The Hope Heart Institute, 528 18th Ave., Seattle, WA 98122.

Abstract

Objective: The purpose of this study was to evaluate in dogs the effect of blood flow alteration on caliber and morphology of in situ internal thoracic arteries. Methods: Six dogs underwent creation of a unilateral distal arteriovenous fistula between the internal thoracic artery and vein at the sixth rib to create high flow, and in six others the internal thoracic artery was unilaterally skeletonized and dissected. For both groups the contralateral internal thoracic artery served as the control; sides were alternated among cases. Blood flow was measured for shear stress calculation before and after surgical alteration. After 2 months, internal thoracic arteries were harvested with the entire anterior chest plate, which was dynamically inflated and fixed with 10% formalin at a controlled pressure of 120 mm Hg after angiography had been done at the same pressure. The luminal diameters were then measured at eight levels on the angiograms. Arterial tissue samples were taken at three levels and embedded, sectioned, and treated with hematoxylin-eosin and Verhoeff-van Gieson stains. Digital imaging analysis was used for quantitative morphometric studies. Results: All fistulas remained patent. In comparison with control arteries, high-flow internal thoracic arteries dilated and low-flow internal thoracic arteries narrowed, which was associated with significant change in shear stress for both groups. There were no substantial structural changes in the walls of either group. Conclusion: In the dog, the luminal diameter of the internal thoracic artery responds to altered blood flow without intimal thickening or other undesirable wall changes.

This article has been cited by other articles:

				O. Galili, K. J. Sattler, J. Herrmann, J. Woodrum, M. Olson, L. O. Lerman, and A. Lerman Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries J. Thorac. Cardiovasc. Surg., April 1, 2005; 129(4): 767 - 772. [Abstract] [Full Text] [PDF]

				D. G. Affleck, H. B. Barner, M. S. Bailey, L. A. Perry, H. Maniar, S. M. Prasad, and R. J. Damiano Jr Flow Dynamics of the Internal Thoracic and Radial Artery T-Graft Ann. Thorac. Surg., October 1, 2004; 78(4): 1290 - 1294. [Abstract] [Full Text] [PDF]

				H. B. Barner Remodeling of arterial conduits in coronary grafting Ann. Thorac. Surg., April 1, 2002; 73(4): 1341 - 1345. [Abstract] [Full Text] [PDF]

				T. Sasajima, V. Bhattacharya, M. Hong-De Wu, Q. Shi, N. Hayashida, and L. R. Sauvage Morphology and histology of human and canine internal thoracic arteries Ann. Thorac. Surg., July 1, 1999; 68(1): 143 - 148. [Abstract] [Full Text] [PDF]

				T. Sasajima, M. H.-D. Wu, Q. Shi, N. Hayashida, and L. R. Sauvage Effect of Skeletonizing Dissection on the Internal Thoracic Artery Ann. Thorac. Surg., April 1, 1998; 65(4): 1009 - 1013. [Abstract] [Full Text] [PDF]