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J Thorac Cardiovasc Surg 1997;113:278-284
© 1997 Mosby, Inc.

SURGERY FOR CONGENITAL HEART DISEASE

PLASMA NEUROPEPTIDE Y AND CATECHOLAMINES IN PEDIATRIC PATIENTS UNDERGOING CARDIAC OPERATIONS

Supported in part by a Young Investigator Award from the Foundation for Anesthesia Education and Research.

Received for publication March 20, 1996 revisions requested May 20, 1996; revisions received August 19, 1996 accepted for publication August 20, 1996. Address for reprints: Lena S. Sun, MD, BH4-440N, 622 W. 168th St., New York, NY 10032.

Abstract

Objective: Our objective was to assess the sympathoadrenal response in pediatric patients undergoing repair of congenital cardiac defects. Methods: Plasma catecholamine (norepinephrine and epinephrine) and neuropeptide Y concentrations were quantified before and after cardiopulmonary bypass to assess the response to cardiopulmonary bypass. To determine the response to aortic occlusion, levels of plasma catecholamines and neuropeptide Y were measured at the time of and immediately after release of the aortic crossclamp. Results: During cardiopulmonary bypass, no significant change in levels of plasma norepinephrine (n = 43), epinephrine (n = 37), or neuropeptide Y (n = 46) was observed. Aortic occlusion induced a significant increase in plasma neuropeptide Y, but not in catecholamines. There was a greater increase in plasma neuropeptide Y in children older than age 1 year than in those younger than 1 year. Conclusions: Plasma neuropeptide Y may be a useful marker of sympathetic nervous system activity. Children younger than age 1 year showed a lesser sympathetic response compared with the response in older children.

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