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J Thorac Cardiovasc Surg 1997;114:123-128
© 1997 Mosby, Inc.

CARDIOPULMONARY BYPASS,
MYOCARDIAL MANAGEMENT, AND SUPPORT TECHNIQUES

TEMPERATURE DURING CARDIOPULMONARY BYPASS FOR CORONARY ARTERY OPERATIONS DOES NOT INFLUENCE POSTOPERATIVE COGNITIVE FUNCTION: A PROSPECTIVE, RANDOMIZED TRIAL

Gilles Plourde, MD, MSca, Annie Sapin Leduc, PhDa, Jean E. Morin, MDb, Benoit DeVarennes, MDb, David Latter, MDb, James Symes, MDb*, Ross Robbins, MDa, Nadine Fosset, RNb, Lucie Couture, RNa, Alain Ptito, PhDc

Supported in part by a grant from the Heart and Stroke Foundation of Quebec.

Presented in part at the 1993 Annual Meeting of the Canadian Anaesthetists' Society, Halifax, Nova Scotia, Canada.

Received for publication July, 31, 1996 revisions requested Sept. 30, 1996; revisions received Jan. 27, 1997 accepted for publication Feb. 13, 1997. Address for reprints: Gilles Plourde, MD, Royal Victoria Hospital, Department of Anaesthesia, 687 Pine Ave. West, Suite S5.05, Montreal, Quebec, Canada H3A 1A1. (E-mail: mdgp{at}musica.mcgill.ca)

Abstract

Objective: The objective was to examine the effect of temperature (28° vs 36° C) during cardiopulmonary bypass on postoperative cognitive functions in a prospective, double-blind, and randomized manner.Methods: Sixty-two patients scheduled for coronary operations were randomized to warm or cold cardiopulmonary bypass. Preoperative and postoperative (7 days) neuropsychologic evaluations were performed by an observer unaware of cardiopulmonary bypass temperature.Results: Fifty-four patients completed the study (cold bypass, n = 24; warm bypass, n = 30). Significant (p < 0.01) postoperative deterioration for tests of psychomotor coordination and verbal memory was noted in both warm and cold groups, but no differences were observed between groups.Conclusion: Temperature during cardiopulmonary bypass for coronary operations does not influence postoperative cognitive function




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