| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 1997;114:195-202
© 1997 Mosby, Inc.
CARDIAC AND PULMONARY REPLACEMENT |
Received for publication Feb. 5, 1996 Revisions requested March 28, 1996; revisions received Feb. 25, 1997 Accepted for publication March 27, 1997. Address for reprints: R. Morton Bolman III, MD, Department of Surgery, University of Minnesota, Box 207 UMHC, 420 Delaware St. SE, Minneapolis, MN 55455.
Abstract
Objective: This study identifies specific clinical and immunologic factors in lung transplant recipients that influence the subsequent development of chronic allograft dysfunction. Methods: The study group consisted of 132 consecutive patients who received lung allografts (76 single, 25 bilateral single, and 31 heart-lung) and survived at least 90 days. One hundred twenty-one patients were used in the analysis that modeled time to development of histologic obliterative bronchiolitis or bronchiolitis obliterans syndrome. Results: Variables noted to have an effect on the time to development of bronchiolitis obliterans syndrome included cytomegalovirus pneumonitis (RR = 3.2, p = 0.001), late acute rejection (RR = 1.3, p = 0.02), human leukocyte antigen mismatches at the A loci (RR = 1.8, p = 0.02), total human leukocyte antigen mismatches (RR = 1.4, p = 0.04), and absence of donor antigen–specific hyporeactivity (52% vs 100% survival free from bronchiolitis obliterans syndrome at 2 years; p = 0.005). Cytomegalovirus pneumonitis had a significant effect on time to obliterative bronchiolitis (RR = 3.6, p = 0.0005), as did donor antigen–specific hyporeactivity (52% vs 100% survival free from obliterative bronchiolitis at 2 years; p = 0.01). In multivariate analysis, cytomegalovirus pneumonitis (RR = 3.2, p = 0.02), human leukocyte antigen mismatches at the A loci (RR = 2.4, p = 0.006), and late acute rejection (RR = 1.3, p = 0.02) were identified as predictors of bronchiolitis obliterans syndrome. Cytomegalovirus pneumonitis was associated with time to development of histologic obliterative bronchiolitis (RR = 2.3, p = 0.02). Conclusions: Several risk factors were associated with the development of chronic allograft dysfunction, which, in turn, had a significant impact on long-term survival. Early identification of lung allograft recipients with risk factors for the development of bronchiolitis obliterans syndrome may allow modification in immunosuppression and antiviral therapy to potentially decrease the prevalence of this disorder. J Thorac Cardiovasc Surg 1997;114:195-202
This article has been cited by other articles:
|
|
 |
|
  T. Tabata, H. Kawakatsu, E. Maidji, T. Sakai, K. Sakai, J. Fang-Hoover, M. Aiba, D. Sheppard, and L. Pereira Induction of an Epithelial Integrin {alpha}v{beta}6 in Human Cytomegalovirus-Infected Endothelial Cells Leads to Activation of Transforming Growth Factor-{beta}1 and Increased Collagen Production Am. J. Pathol., April 1, 2008; 172(4): 1127 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Russo, D. I. Sternberg, K. N. Hong, R. A. Sorabella, A. J. Moskowitz, A. C. Gelijns, J. R. Wilt, F. D'Ovidio, S. M. Kawut, S. M. Arcasoy, et al. Postlung Transplant Survival is Equivalent Regardless of Cytomegalovirus Match Status Ann. Thorac. Surg., October 1, 2007; 84(4): 1129 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Lande, J. Patil, N. Li, T. R. Berryman, R. A. King, and M. I. Hertz Novel Insights into Lung Transplant Rejection by Microarray Analysis Proceedings of the ATS, January 1, 2007; 4(1): 44 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Benden, O Harpur-Sinclair, A S Ranasinghe, J C Hartley, M J Elliott, and P Aurora Surveillance bronchoscopy in children during the first year after lung transplantation: is it worth it? Thorax, January 1, 2007; 62(1): 57 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Al-Githmi, N. Batawil, N. Shigemura, M. Hsin, T. W. lee, G.-W. He, and A. Yim Bronchiolitis obliterans following lung transplantation Eur. J. Cardiothorac. Surg., December 1, 2006; 30(6): 846 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Moffatt-Bruce, J. Karamichalis, R. C. Robbins, R. I. Whyte, J. Theodore, and B. A. Reitz Are Heart-Lung Transplant Recipients Protected From Developing Bronchiolitis Obliterans Syndrome? Ann. Thorac. Surg., January 1, 2006; 81(1): 286 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Hartwig, J. Z. Appel, B. Li, C.-C. Hsieh, Y. H. Yoon, S. S. Lin, W. Irish, W. Parker, and R. D. Davis Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation J. Thorac. Cardiovasc. Surg., January 1, 2006; 131(1): 209 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Helantera, R. Loginov, P. Koskinen, T. Tornroth, C. Gronhagen-Riska, and I. Lautenschlager Persistent cytomegalovirus infection is associated with increased expression of TGF-{beta}1, PDGF-AA and ICAM-1 and arterial intimal thickening in kidney allografts Nephrol. Dial. Transplant., April 1, 2005; 20(4): 790 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tamm, C. L. Aboyoun, P. N. Chhajed, S. Rainer, M. A. Malouf, and A. R. Glanville Treated Cytomegalovirus Pneumonia Is Not Associated with Bronchiolitis Obliterans Syndrome Am. J. Respir. Crit. Care Med., November 15, 2004; 170(10): 1120 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Khalifah, R. R. Hachem, M. M. Chakinala, K. B. Schechtman, G. A. Patterson, D. P. Schuster, T. Mohanakumar, E. P. Trulock, and M. J. Walter Respiratory Viral Infections Are a Distinct Risk for Bronchiolitis Obliterans Syndrome and Death Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 181 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Burch and P Aurora Current status of paediatric heart, lung, and heart-lung transplantation Arch. Dis. Child., April 1, 2004; 89(4): 386 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Boehler and M. Estenne Post-transplant bronchiolitis obliterans Eur. Respir. J., December 1, 2003; 22(6): 1007 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Gimino, J. D. Lande, T. R. Berryman, R. A. King, and M. I. Hertz Gene Expression Profiling of Bronchoalveolar Lavage Cells in Acute Lung Rejection Am. J. Respir. Crit. Care Med., November 15, 2003; 168(10): 1237 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Chalermskulrat, I. P. Neuringer, J. L. Schmitz, D. J. Catellier, M. J. Gurka, S. H. Randell, and R. M. Aris Human Leukocyte Antigen Mismatches Predispose to the Severity of Bronchiolitis Obliterans Syndrome After Lung Transplantation Chest, June 1, 2003; 123(6): 1825 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Johnson, A. T. Iacono, A. Zeevi, K. R. McCurry, and S. R. Duncan Statin Use Is Associated with Improved Function and Survival of Lung Allografts Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1271 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kita, K. Suzuki, H. Nogimura, T. Takahashi, and T. Kazui CTLA4Ig-gene transfection inhibits obliterative airway disease in rats Ann. Thorac. Surg., April 1, 2003; 75(4): 1123 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chalermskulrat, I. P. Neuringer, W. J. Brickey, N. J. Felix, S. H. Randell, J. P. Ting, and R. M. Aris Hierarchical Contributions of Allorecognition Pathways in Chronic Lung Rejection Am. J. Respir. Crit. Care Med., April 1, 2003; 167(7): 999 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.M. Verleden, L.J. Dupont, M. Delcroix, D. Van Raemdonck, J. Vanhaecke, T. Lerut, and M. Demedts Exhaled nitric oxide after lung transplantation: impact of the native lung Eur. Respir. J., March 1, 2003; 21(3): 429 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Davis Jr, C. L. Lau, S. Eubanks, R. H. Messier, D. Hadjiliadis, M. P. Steele, and S. M. Palmer Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(3): 533 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Estenne and M. I. Hertz Bronchiolitis Obliterans after Human Lung Transplantation Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 440 - 444. [Full Text] [PDF]
|
|
|
|
|
|
K. Inkinen, A. Soots, L. Krogerus, C. Bruggeman, J. Ahonen, and I. Lautenschlager Cytomegalovirus increases collagen synthesis in chronic rejection in the rat Nephrol. Dial. Transplant., May 1, 2002; 17(5): 772 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Fiser, C. G. Tribble, S. M. Long, A. K. Kaza, J. A. Kern, D. R. Jones, M. K. Robbins, and I. L. Kron Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome Ann. Thorac. Surg., April 1, 2002; 73(4): 1041 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. SCHULMAN, A. D. WEINBERG, C. C. McGREGOR, N. M. SUCIU-FOCA, and S. ITESCU Influence of Donor and Recipient HLA Locus Mismatching on Development of Obliterative Bronchiolitis after Lung Transplantation Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 437 - 442. [Abstract] [Full Text]
|
|
|
|
|
|
J. W. K. van den BERG, A. GEERTSMA, W. van der BIJ, G. H. KOËTER, W. J. de BOER, D. S. POSTMA, and E. M. ten VERGERT Bronchiolitis Obliterans Syndrome after Lung Transplantation and Health-related Quality of Life Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1937 - 1941. [Abstract] [Full Text]
|
|
|
|
 |
|
 I. G. Sia and R. Patel New Strategies for Prevention and Therapy of Cytomegalovirus Infection and Disease in Solid-Organ Transplant Recipients Clin. Microbiol. Rev., January 1, 2000; 13(1): 83 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Gerbase, D. Dubois, C. Rothmeier, A. Spiliopoulos, W. Wunderli, and L. P. Nicod Costs and Outcomes of Prolonged Cytomegalovirus Prophylaxis to Cover the Enhanced Immunosuppression Phase Following Lung Transplantation Chest, November 1, 1999; 116(5): 1265 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Huddleston, E. N. Mendeloff, A. H. Cohen, S. C. Sweet, D. T. Balzer, and G. B. Mallory Jr Lung retransplantation in children Ann. Thorac. Surg., July 1, 1998; 66(1): 199 - 204. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
