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J Thorac Cardiovasc Surg 1997;114:891-902
© 1997 Mosby, Inc.
SURGERY FOR ACQUIRED HEART DISEASE |
Received for publication May 7, 1997 Revisions requested June 9, 1997 Revisions received June 25, 1997 Accepted for publication July 2, 1997 Address for reprints: David B. Ross, MD, FRCSC, IWK Grace Hospital, P.O. Box 3070, Halifax, Nova Scotia, Canada B3J 3G9.
Abstract
Objective: The histopathologic changes of fresh rat aortic valve allografts over time and the effect of cryopreservation were examined. Methods: Fifty-six syngeneic and allogeneic rat aortic valves were transplanted, either fresh or after cryopreservation, and then at different time points they were explanted and histologically examined in a blinded fashion. Results: Histopathologic changes in the first week are similar in syngeneic and allogeneic grafts. Fresh syngeneic grafts and leaflets retained normal structure up to 56 days. Allogeneic grafts showed retrovalvular thrombus formation with leaflet ghosts and neointimal proliferation. Cryopreservation did not alter this process. Conclusions: Cardiac allograft valves in the rat model undergo changes that are characteristic of cell-mediated rejection and lead to valve failure.
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