| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 1997;114:940-947
© 1997 Mosby, Inc.
GENERAL THORACIC SURGERY |
Received for publication May 5, 1997 Revisions requested July 11, 1997 Revisions received July 31, 1997 Accepted for publication July 31, 1997 Address for reprints: James S. McCaughan, Jr., MD, FACS, FCCP, 323 E. Town St., Columbus, OH 43215.
Abstract
Background: After intravenous injection, the photosensitizer dihematoporphyrin ether is selectively retained in tumor cells. This photosensitizer absorbs 630 nm wavelength light energy and produces a singlet oxygen that destroys the tumor. Photodynamic therapy was performed on endobronchial tumors with the use of light generated by an argon dye laser system delivered through cylinder diffusing tip quartz fibers passed through the biopsy channel of a flexible endoscope. Objectives: Our objectives were to determine factors affecting survivals, benefits, and complications. Methods: From 1982 to May 1996, photodynamic therapy was performed on 175 patients with endobronchial tumors. Sixteen had stage I disease, 9 stage II, 42 stage IIIA, 64 stage IIIB, and 44 stage IV. All were followed up until death or November 1996. Results: Multivariate analysis of survival of the effects of age, sex, race, histologic features, Karnofsky Performance Status, and clinical stage showed the clinical stage ( p < 0.0001) to be the most statistically significant factor. Sixteen patients with stage I disease had a 93% 5-year disease-related estimated survival. Median (months) survivals were as follows: stage I = not reached; stage II = 22.5; stage IIIA = 5.7; stage IIIB = 55; and stage IV = 5.0. Performance status does become significant when it reaches 50 but was not significant for stages I or II. Conclusions: Photodynamic therapy may be considered as an alternative treatment for patients under consideration for surgical treatment for stage I carcinoma in whom the risk of surgery is high. The length of palliation for patients with noncurative disease was equal to or better than that reported historically for most other treatment regimens.
This article has been cited by other articles:
|
|
 |
|
  C. J.A. Haasbeek, S. Senan, E. F. Smit, M. A. Paul, B. J. Slotman, and F. J. Lagerwaard Critical Review of Nonsurgical Treatment Options for Stage I Non-Small Cell Lung Cancer Oncologist, March 1, 2008; 13(3): 309 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Triesscheijn, P. Baas, J. H. M. Schellens, and F. A. Stewart Photodynamic Therapy in Oncology Oncologist, October 1, 2006; 11(9): 1034 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J-M. Vergnon, R. M. Huber, and K. Moghissi Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur. Respir. J., July 1, 2006; 28(1): 200 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Gaissert, H. C. Grillo, M. B. Shadmehr, C. D. Wright, M. Gokhale, J. C. Wain, and D. J. Mathisen Uncommon primary tracheal tumors. Ann. Thorac. Surg., July 1, 2006; 82(1): 268 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Asimakopoulos, J. Beeson, J. Evans, and M. O. Maiwand Cryosurgery for Malignant Endobronchial Tumors: Analysis of Outcome Chest, June 1, 2005; 127(6): 2007 - 2014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Freitag, A Ernst, M Thomas, R Prenzel, B Wahlers, and H-N Macha Sequential photodynamic therapy (PDT) and high dose brachytherapy for endobronchial tumour control in patients with limited bronchogenic carcinoma Thorax, September 1, 2004; 59(9): 790 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ernst, D. Feller-Kopman, H. D. Becker, and A. C. Mehta Central Airway Obstruction Am. J. Respir. Crit. Care Med., June 15, 2004; 169(12): 1278 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Maziak, B. R. Markman, J. A. MacKay, and W. K. Evans Photodynamic therapy in nonsmall cell lung cancer: a systematic review Ann. Thorac. Surg., April 1, 2004; 77(4): 1484 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Moghissi and K. Dixon Is bronchoscopic photodynamic therapy a therapeutic option in lung cancer? Eur. Respir. J., September 1, 2003; 22(3): 535 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Moghissi, K. Dixon, and J.A. C. Thorpe A method for video-assisted thoracoscopic photodynamic therapy (VAT-PDT) Interactive CardioVascular and Thoracic Surgery, September 1, 2003; 2(3): 373 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ernst, G. A. Silvestri, and D. Johnstone Interventional Pulmonary Procedures: Guidelines from the American College of Chest Physicians Chest, May 1, 2003; 123(5): 1693 - 1717. [Full Text] [PDF]
|
|
|
|
|
|
S. G. Spiro and J. C. Porter Lung Cancer--Where Are We Today?: Current Advances in Staging and Nonsurgical Treatment Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1166 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Bauer, S. M. Hahn, F. R. Spitz, A. Kachur, E. Glatstein, and D. L. Fraker Preliminary Report of Photodynamic Therapy for Intraperitoneal Sarcomatosis Ann. Surg. Oncol., April 1, 2001; 8(3): 254 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ghaye and R.F. Dondelinger Imaging guided thoracic interventions Eur. Respir. J., March 1, 2001; 17(3): 507 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hettiaratchy, J. Clarke, J. Taubel, and C. Besa Drug points: Burns after photodynamic therapy BMJ, May 6, 2000; 320(7244): 1245 - 1245. [Full Text]
|
|
|
|
 |
|
 G. Massard, C. Doddoli, B. Gasser, X. Ducrocq, R. Kessler, C. Schumacher, G.-M. Jung, and J.-M. Wihlm Prognostic implications of a positive bronchial resection margin Eur. J. Cardiothorac. Surg., May 1, 2000; 17(5): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. W. Engbrecht, C. Menon, A. V. Kachur, S. M. Hahn, and D. L. Fraker Photofrin-mediated Photodynamic Therapy Induces Vascular Occlusion and Apoptosis in a Human Sarcoma Xenograft Model Cancer Res., September 1, 1999; 59(17): 4334 - 4342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Osaki, T. Hanagiri, R. Nakanishi, I. Yoshino, S. Taga, and K. Yasumoto Bronchial Arterial Infusion Is an Effective Therapeutic Modality for Centrally Located Early-Stage Lung Cancer: Results of a Pilot Study Chest, May 1, 1999; 115(5): 1424 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. I. Fielding, G. A. Buonaccorsi, A. J. MacRobert, A. M. Hanby, M. R. Hetzel, and S. G. Bown Fine-Needle Interstitial Photodynamic Therapy of the Lung Parenchyma: Photosensitizer Distribution and Morphologic Effects of Treatment Chest, February 1, 1999; 115(2): 502 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Moghissi, K. Dixon, M. Stringer, T. Freeman, A. Thorpe, and S. Brown The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer: experience of 100 cases Eur. J. Cardiothorac. Surg., January 1, 1999; 15(1): 1 - 6. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
