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J Thorac Cardiovasc Surg 1998;115:1080-1084
© 1998 Mosby, Inc.


SURGERY FOR ACQUIRED HEART DISEASE

Late results of a valve-preserving operation in patients with aneurysms of the ascending aorta and root

Magdi H. Yacoub, PhD, FRCS, Petra Gehle, MD, V. Chandrasekaran, FRCS, Emma J. Birks, MRCP, BSc, Anne Child, MD, Rosemary Radley-Smith, FRCP

Supported in part by the British Heart Foundation. Magdi H. Yacoub is a British Heart Foundation Professor of Cardiothoracic Surgery and Emma J. Birks is a Research Fellow supported by the British Heart Foundation (Project Grant 96152).

Read at the Seventy-seventh Annual Meeting of The American Association for Thoracic Surgery, Washington, D.C., May 4-7, 1997.

Received for publication May 5, 1997. Revisions requested Sept. 9, 1997; revisions received Dec. 1, 1997. Accepted for publication Dec. 8, 1997. Address for reprints: Sir Magdi Yacoub, FRCS, Professor of Cardiothoracic Surgery, National Heart and Lung Institute, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, UB9 6JH, United Kingdom.

Abstract

Objectives: There is still no agreement about the best method of dealing with malfunction of the aortic valve caused by aneurysm or dissection of the aortic root. The experience, rationale, and development of a valve-preserving technique introduced and used since 1979 is described.
Methods: During this period 158 patients (78% of all patients undergoing resection of aneurysm of the ascending aorta) were operated on using this technique. Their ages ranged from 2 to 72 years (mean 46.6 years). Of the patients 107 were male and 51 were female. A total of 68 patients had skeletal manifestations of Marfan's syndrome. The original disease was chronic aneurysm of the ascending aorta or root in 92 (58.2%), chronic dissection in 17 (10.8%), and acute dissection in 49 (31%) patients. One hundred eleven additional procedures were performed in 84 patients. In all there were five early deaths (4.6% ± 2%) in the 109 patients with chronic aneurysm and one death in the 103 patients operated on electively (0.97% ± 0.9%). Actuarial survival for patients operated on for chronic aneurysm was 93.3%, 88.0%, 79.0%, and 57.9% at 1, 5, 10, and 15 years and 96.8%, 91.2%, 82.0%, and 60.0% for those operated on electively. Actuarial survival for patients operated on for acute dissection was 72.8%, 63.4%, and 53.3% at 1, 5, and 10 years. The probability of needing reoperation was 3.0% ± 2%, 11% ± 0.5%, and 11% ± 0.5% at 1, 5, and 10 years. There were no instances of infective endocarditis or thromboembolic complications except in two patients operated on early in the series who had cusp extension. No anticoagulants were used. Echocardiography showed reduction in left ventricular end-systolic and end-diastolic dimensions, which was maintained. At the end of follow-up trivial or no aortic regurgitation was demonstrated in 63.6%, mild to moderate in 33.3%, and severe in 3%.
Conclusions: Valve-sparing operations are possible in a large proportion of patients with aneurysms of the ascending aorta and the medium and long-term results are encouraging.




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K. J. Zehr, T. A. Orszulak, C. J. Mullany, A. Matloobi, R. C. Daly, J. A. Dearani, T. M. Sundt III, F. J. Puga, G. K. Danielson, and H. V. Schaff
Surgery for Aneurysms of the Aortic Root: A 30-Year Experience
Circulation, September 14, 2004; 110(11): 1364 - 1371.
[Abstract] [Full Text] [PDF]


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CirculationHome page
F. Langer, D. Aicher, A. Kissinger, O. Wendler, H. Lausberg, R. Fries, and H.-J. Schafers
Aortic Valve Repair Using a Differentiated Surgical Strategy
Circulation, September 14, 2004; 110(11_suppl_1): II-67 - II-73.
[Abstract] [Full Text] [PDF]


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ICVTSHome page
T. Kazui, H. Izumoto, M. Nasu, and K. Kawazoe
Perioperative changes in dynamic aortic root morphology after Yacoub's root remodeling and concomitant aortic annuloplasty
Interactive CardioVascular and Thoracic Surgery, September 1, 2004; 3(3): 465 - 469.
[Abstract] [Full Text] [PDF]


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Eur. J. Cardiothorac. Surg.Home page
T. Carrel, L. Beyeler, A. Schnyder, P. Zurmuhle, P. Berdat, J. Schmidli, and F. S. Eckstein
Reoperations and late adverse outcome in Marfan patients following cardiovascular surgery
Eur. J. Cardiothorac. Surg., May 1, 2004; 25(5): 671 - 675.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
K. Furukawa, H. Ohteki, Z.-L. Cao, Y. Narita, Y. Okazaki, S. Ohtsubo, and T. Itoh
Evaluation of native valve-sparing aortic root reconstruction with direct imaging-- reimplantation or remodeling?
Ann. Thorac. Surg., May 1, 2004; 77(5): 1636 - 1641.
[Abstract] [Full Text] [PDF]


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CirculationHome page
M. H. Yacoub and L. H. Cohn
Novel Approaches to Cardiac Valve Repair: From Structure to Function: Part II
Circulation, March 9, 2004; 109(9): 1064 - 1072.
[Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
K. Minakata, H. V. Schaff, K. J. Zehr, J. A. Dearani, R. C. Daly, T. A. Orszulak, F. J. Puga, and G. K. Danielson
Is repair of aortic valve regurgitation a safe alternative to valve replacement?
J. Thorac. Cardiovasc. Surg., March 1, 2004; 127(3): 645 - 653.
[Abstract] [Full Text] [PDF]


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Eur. J. Cardiothorac. Surg.Home page
R. A. Hopkins
Aortic valve leaflet sparing and salvage surgery: evolution of techniques for aortic root reconstruction
Eur. J. Cardiothorac. Surg., December 1, 2003; 24(6): 886 - 897.
[Abstract] [Full Text] [PDF]


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Asian Cardiovasc. Thorac. Ann.Home page
K. Kirali, V. Erentug, M. B Rabus, A. Izgi, N. U Bozbuga, K. Erkanli, E. Akinci, and C. Yakut
Extensive Aortic Surgery in Marfan Syndrome: 16-Year Experience
Asian Cardiovasc Thorac Ann, December 1, 2003; 11(4): 337 - 341.
[Abstract] [Full Text] [PDF]


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CirculationHome page
R. G. Leyh, K. Kallenbach, M. Karck, C. Hagl, S. Fischer, and A. Haverich
Impact of Preoperative Aortic Root Diameter on Long-Term Aortic Valve Function After Valve Sparing Aortic Root Reimplantation
Circulation, September 9, 2003; 108(90101): II-285 - 290.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
P. Masetti, V. A. Davila-Roman, and N. T. Kouchoukos
Valve-sparing procedure for dilatation of the autologous pulmonary artery and ascending aorta after the Ross operation
Ann. Thorac. Surg., September 1, 2003; 76(3): 915 - 916.
[Abstract] [Full Text] [PDF]


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CirculationHome page
C. A. Nienaber and K. A. Eagle
Aortic Dissection: New Frontiers in Diagnosis and Management: Part II: Therapeutic Management and Follow-Up
Circulation, August 12, 2003; 108(6): 772 - 778.
[Full Text] [PDF]


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Eur. J. Cardiothorac. Surg.Home page
T. Carrel, P. Berdat, M. Pavlovic, S. Sukhanov, L. Englberger, and J.-P. Pfammatter
Surgery of the dilated aortic root and ascending aorta in pediatric patients: techniques and results
Eur. J. Cardiothorac. Surg., August 1, 2003; 24(2): 249 - 254.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
A. W. Erasmi, U. Stierle, J.F. M. Bechtel, C. Schmidtke, H. H. Sievers, and E. G. Kraatz
Up to 7 years' experience with valve-sparing aortic root remodeling/reimplantation for acute type a dissection
Ann. Thorac. Surg., July 1, 2003; 76(1): 99 - 104.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
A. D. Milano, S. Pratali, G. Mecozzi, P. Boraschi, G. Braccini, E. Magagnini, and U. Bortolotti
Fate of coronary ostial anastomoses after the modified Bentall procedure
Ann. Thorac. Surg., June 1, 2003; 75(6): 1797 - 1801.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
D. C. Miller
Valve-sparing aortic root replacement in patients with the Marfan syndrome
J. Thorac. Cardiovasc. Surg., April 1, 2003; 125(4): 773 - 778.
[Full Text] [PDF]


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Card Surg AdultHome page
T. E. David
Aortic Valve Repair and Aortic Valve-Sparing Operations
Card. Surg. Adult, January 1, 2003; 2(2003): 811 - 824.
[Full Text]


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Card Surg AdultHome page
C. A. Anderson, R. J. Rizzo, and L. H. Cohn
Ascending Aortic Aneurysms
Card. Surg. Adult, January 1, 2003; 2(2003): 1123 - 1148.
[Full Text]


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Ann. Thorac. Surg.Home page
K. Kallenbach, C. Hagl, T. Walles, R. G. Leyh, K. Pethig, A. Haverich, and W. Harringer
Results of valve-sparing aortic root reconstruction in 158 consecutive patients
Ann. Thorac. Surg., December 1, 2002; 74(6): 2026 - 2033.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
H. Matsuda, H. Ichikawa, S. Iwai, and T. Takahashi
Modified aortic root remodeling for annuloaortic ectasia with abnormal coronary take-off
Ann. Thorac. Surg., November 1, 2002; 74(5): 1687 - 1689.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
T. E. David, J. Ivanov, S. Armstrong, C. M. Feindel, and G. D. Webb
Aortic valve-sparing operations in patients with aneurysms of the aortic root or ascending aorta
Ann. Thorac. Surg., November 1, 2002; 74(5): S1758 - 1761.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
H.-J. Schafers, D. Aicher, and F. Langer
Correction of leaflet prolapse in valve-preserving aortic replacement: pushing the limits?
Ann. Thorac. Surg., November 1, 2002; 74(5): S1762 - 1764.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
K. Kallenbach, M. Karck, R. G. Leyh, C. Hagl, T. Walles, W. Harringer, and A. Haverich
Valve-sparing aortic root reconstruction in patients with significant aortic insufficiency
Ann. Thorac. Surg., November 1, 2002; 74(5): S1765 - 1768.
[Abstract] [Full Text] [PDF]


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Eur. J. Cardiothorac. Surg.Home page
E. Lansac, H.S. Lim, Y. Shomura, K.H. Lim, N.T. Rice, W. Goetz, C. Acar, and C.M.G. Duran
A four-dimensional study of the aortic root dynamics
Eur. J. Cardiothorac. Surg., October 1, 2002; 22(4): 497 - 503.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
J. S. Ikonomidis and D. C. Miller
Stentless bioprosthetic aortic valve replacement after valve-sparing aortic root replacement
J. Thorac. Cardiovasc. Surg., October 1, 2002; 124(4): 848 - 851.
[Full Text] [PDF]


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CirculationHome page
R. G. Leyh, S. Fischer, K. Kallenbach, T. Kofidis, K. Pethig, W. Harringer, and A. Haverich
High Failure Rate After Valve-sparing Aortic Root Replacement Using the "Remodeling Technique" in Acute Type A Aortic Dissection
Circulation, September 24, 2002; 106(12_suppl_1): I-229 - I-233.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
T. E. David
Aortic valve sparing operations
Ann. Thorac. Surg., April 1, 2002; 73(4): 1029 - 1030.
[Full Text] [PDF]


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Ann. Thorac. Surg.Home page
K. Morishita, G. Murakami, T. Koshino, J. Fukada, Y. Fujisawa, T. Mawatari, and T. Abe
Aortic root remodeling operation: how do we tailor a tube graft?
Ann. Thorac. Surg., April 1, 2002; 73(4): 1117 - 1121.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
S. Westaby, S. Saito, and T. Katsumata
Acute type A dissection: conservative methods provide consistently low mortality
Ann. Thorac. Surg., March 1, 2002; 73(3): 707 - 713.
[Abstract] [Full Text] [PDF]


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Eur. J. Cardiothorac. Surg.Home page
S. Westaby, S. Saito, K. Anastasiadis, N. Moorjani, and X.Y. Jin
Aortic root remodeling in atheromatous aneurysms: The role of selected sinus repair
Eur. J. Cardiothorac. Surg., March 1, 2002; 21(3): 459 - 464.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
M. E. Lewis, T. J. Jones, A. M. Ranasinghe, J. R. Lewis, and R. S. Bonser
Homograft aortic root with prosthetic extension as a treatment for aneurysm of the proximal aorta in elderly patients
J. Thorac. Cardiovasc. Surg., March 1, 2002; 123(3): 573 - 575.
[Full Text] [PDF]


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Ann. Thorac. Surg.Home page
N. Simon-Kupilik, H. Schima, L. Huber, R. Moidl, G. Wipplinger, U. Losert, E. Wolner, and P. Simon
Prosthetic replacement of the aorta is a risk factor for aortic root aneurysm development
Ann. Thorac. Surg., February 1, 2002; 73(2): 455 - 459.
[Abstract] [Full Text] [PDF]




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