| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 1998;116:276-280
© 1998 Mosby, Inc.
General Thoracic Surgery |
Supported by grants from the Ministry of Health and Welfare, Japan.
Received for publication August 1, 1997. Revisions requested Feb. 2, 1998; revisions received March 11, 1998. Accepted for publication April 16, 1998. Address for reprints: Tsuneyo Takizawa, MD, Department of Thoracic Surgery, Niigata Cancer Center Hospital, 2 Kawagishi-cho, 951 Niigata, Japan.
Objective: Our aim in this study is to clarify the clinical and pathologic features of small peripheral adenocarcinoma of the lung with special emphasis on intraoperative identification of lymph node metastasis.
Patients and methods: Between 1980 and 1996, 157 patients underwent lobectomy and complete hilar/mediastinal lymphadenectomy for small (1.1 to 2.0 cm in diameter) peripheral adenocarcinoma of the lung. The intraoperative assessment, the distribution of metastatic lymph nodes, and the association between the tumor's histopathologic characteristics and lymph node metastasis were retrospectively investigated in this study.
Results: Postoperative examination revealed lymph node metastasis in 27 (17%) patients. Lymph node metastases were not noticed during the operation in 19 of these 27 patients. Metastases were localized in single lymph nodes in 10 patients; the metastates were distributed over a segmental, a lobar, an interlobar, and a mediastinal lymph node. The prevalence of lymph node metastasis was as follows: Of 92 patients with well-differentiated adenocarcinoma, seven (8%) had lymph node metastases; of the 65 patients with other types of tumors, 20 (31%) had lymph node metastases. Of 120 patients without pleural involvement, 13 (11%) had lymph node metastases; of the 37 with pleural involvement, 14 (38%) had lymph node metastases. Five-year survivals were estimated at 91% ± 6% (mean ± 95% confidence interval) for 130 patients with N0 tumor and 30% ± 22% for 27 patients with N1 or N2 tumor.
Conclusions: Intraoperative assessment is not reliable for identifying lymph node metastasis. Lobectomy and complete hilar/mediastinal lymphadenectomy are necessary to determine N stage rigidly. Histologic degree of differentiation and pleural involvement are significantly associated with lymph node metastasis.
This article has been cited by other articles:
|
|
 |
|
  B. Jeremic Low Incidence of Isolated Nodal Failures After Involved-Field Radiation Therapy for Non Small-Cell Lung Cancer: Blinded by the Light? J. Clin. Oncol., December 10, 2007; 25(35): 5543 - 5545. [Full Text] [PDF]
|
|
|
|
 |
|
 J.-J. Hung, C.-Y. Wang, M.-H. Huang, B.-S. Huang, W.-H. Hsu, and Y.-C. Wu Prognostic factors in resected stage I non small cell lung cancer with a diameter of 3 cm or less: Visceral pleural invasion did not influence overall and disease-free survival J. Thorac. Cardiovasc. Surg., September 1, 2007; 134(3): 638 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. Rusch Mediastinoscopy: An Endangered Species? J. Clin. Oncol., November 20, 2005; 23(33): 8283 - 8285. [Full Text] [PDF]
|
|
|
|
|
|
K. Shimizu, J. Yoshida, K. Nagai, M. Nishimura, G. Ishii, Y. Morishita, and Y. Nishiwaki Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 160 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Keenan, R. J. Landreneau, R. H. Maley Jr, D. Singh, R. Macherey, S. Bartley, and T. Santucci Segmental resection spares pulmonary function in patients with stage I lung cancer Ann. Thorac. Surg., July 1, 2004; 78(1): 228 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Matsuguma, R. Nakahara, M. Anraku, T. Kondo, Y. Tsuura, Y. Kamiyama, K. Mori, and K. Yokoi Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung Eur. J. Cardiothorac. Surg., June 1, 2004; 25(6): 1102 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Osaki, A. Nagashima, T. Yoshimatsu, S. Yamada, and K. Yasumoto Visceral pleural involvement in nonsmall cell lung cancer: prognostic significance Ann. Thorac. Surg., May 1, 2004; 77(5): 1769 - 1773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kondo, K. Yamada, Y. Kitayama, and S. Hoshi Peripheral lung adenocarcinomas: 10 mm or less in diameter Ann. Thorac. Surg., August 1, 2003; 76(2): 350 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Kang, K. D. Kim, and K. Y. Chung Prognostic value of visceral pleura invasion in non-small cell lung cancer Eur. J. Cardiothorac. Surg., June 1, 2003; 23(6): 865 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aoki, M. Tsuchida, T. Watanabe, T. Hashimoto, T. Koike, T. Hirono, and J.-i. Hayashi Surgical strategy for clinical stage I non-small cell lung cancer in octogenarians Eur. J. Cardiothorac. Surg., April 1, 2003; 23(4): 446 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Suzuki, H. Asamura, M. Kusumoto, H. Kondo, and R. Tsuchiya "Early" peripheral lung cancer: prognostic significance of ground glass opacity on thin-section computed tomographic scan Ann. Thorac. Surg., November 1, 2002; 74(5): 1635 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. Rusch High-resolution computed tomography in clinical T1 N0 M0 adenocarcinoma of the lung J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 221 - 222. [Full Text] [PDF]
|
|
|
|
|
|
T. Bando, K. Yamagihara, Y. Ohtake, R. Miyahara, F. Tanaka, S. Hasegawa, K. Inui, and H. Wada A new method of segmental resection for primary lung cancer: intermediate results Eur. J. Cardiothorac. Surg., May 1, 2002; 21(5): 894 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Liptay, S. C. Grondin, W. A. Fry, C. Pozdol, D. Carson, C. Knop, G. A. Masters, R. M. Perlman, and W. Watkin Intraoperative Sentinel Lymph Node Mapping in Non-Small-Cell Lung Cancer Improves Detection of Micrometastases J. Clin. Oncol., April 15, 2002; 20(8): 1984 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takamochi, K. Nagai, J. Yoshida, K. Suzuki, Y. Ohde, M. Nishimura, S. Sasaki, and Y. Nishiwaki Pathologic N0 status in pulmonary adenocarcinoma is predictable by combining serum carcinoembryonic antigen level and computed tomographic findings J. Thorac. Cardiovasc. Surg., August 1, 2001; 122(2): 325 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wu, Y. Ohta, H. Minato, Y. Tsunezuka, M. Oda, Y. Watanabe, and G. Watanabe Nodal occult metastasis in patients with peripheral lung adenocarcinoma of 2.0 cm or less in diameter Ann. Thorac. Surg., June 1, 2001; 71(6): 1772 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Manac'h, M. Riquet, J. Medioni, F. Le Pimpec-Barthes, A. Dujon, and C. Danel Visceral pleura invasion by non-small cell lung cancer: an underrated bad prognostic factor Ann. Thorac. Surg., April 1, 2001; 71(4): 1088 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamato, M. Tsuchida, T. Watanabe, T. Aoki, N. Koizumi, H. Umezu, and J.-i. Hayashi Early results of a prospective study of limited resection for bronchioloalveolar adenocarcinoma of the lung Ann. Thorac. Surg., March 1, 2001; 71(3): 971 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yamanaka, T. Hirai, T. Fujimoto, Y. Ohtake, and F. Konishi Analyses of segmental lymph node metastases and intrapulmonary metastases of small lung cancer Ann. Thorac. Surg., November 1, 2000; 70(5): 1624 - 1628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takamochi, K. Nagai, K. Suzuki, J. Yoshida, Y. Ohde, and Y. Nishiwaki Clinical Predictors of N2 Disease in Non-small Cell Lung Cancer Chest, June 1, 2000; 117(6): 1577 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Higashiyama, K. Kodama, H. Yokouchi, K. Takami, M. Mano, S. Kido, and K. Kuriyama Prognostic value of bronchiolo-alveolar carcinoma component of small lung adenocarcinoma Ann. Thorac. Surg., December 1, 1999; 68(6): 2069 - 2073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takizawa, M. Haga, N. Yagi, M. Terashima, H. Uehara, A. Yokoyama, and Y. Kurita PULMONARY FUNCTION AFTER SEGMENTECTOMY FOR SMALL PERIPHERAL CARCINOMA OF THE LUNG J. Thorac. Cardiovasc. Surg., September 1, 1999; 118(3): 536 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Ginsberg Invited commentary Ann. Thorac. Surg., November 1, 1998; 66(5): 1790 - 1790. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
