HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Champsaur, G Articles by Ninet, J Search for Related Content PubMed PubMed Citation Articles by Champsaur, G Articles by Ninet, J

The Journal of Thoracic and Cardiovascular Surgery, Vol 116, 793-804, Copyright © 1998 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Long-term clinical and hemodynamic evaluation of porcine valved conduits implanted from the right ventricle to the pulmonary artery

G Champsaur, J Robin, A Curtil, F Tronc, C Vedrinne, F Sassolas, A Bozio and J Ninet
Department of Cardiovascular Surgery, Hopital Cardiologique Louis Pradel, and Claude Bernard University, Lyon, France.

OBJECTIVE: This retrospective study was initiated to evaluate the long- term results of valved prosthetic conduits implanted in the right ventricular outflow tract in patients with complex ventricular- pulmonary discontinuity. METHODS: A cohort of 103 patients out of 127 (24 early deaths, 19%) operated on between 1973 and 1996 with porcine valved conduits was available for evaluation, with a follow-up ranging from 1 to 21.6 years (mean follow-up 8.4 +/- 6 years). A total of 74 hemodynamic studies were performed after the operation, 50 patients having undergone at least 1 cardiac catheterization during the follow- up period. RESULTS: There were 16 late deaths, and the actuarial survivals, including early mortality, were 72.9% +/- 4% at 5 years, 63.1% +/- 5% at 10 years, and 58.2% +/- 5% at 15 years, at which time 20 patients were still available for review and exposed to the risk of dying. The mean peak systolic gradient across the right ventricular outflow tract was plotted as a function of time, showing a gradual increase and a significant step-up after the eighth year, from 43 +/- 36 to 69 +/- 19 mm Hg (P < .005). Reoperation was required for progressive conduit obstruction between 1.1 and 17.7 years after implantation (mean 7.4 +/- 4.8 years) in 25 patients (24%, 70% CL 15%- 33%), with generally very few symptoms, or for residual ventricular septal defect in 3 patients. Freedom from reoperation was 79.5% +/- 5% at 10 years and 65.8% +/- 7% at 15 years. CONCLUSIONS: Porcine conduits may represent a valuable alternative to biologic substitutes with similar long-term results. Given the few symptoms, progressive conduit stenosis after the eighth postoperative year imposes a yearly noninvasive patient evaluation during the follow-up.

This article has been cited by other articles:

				O. Raisky, W. B. Ali, F. Bajolle, D. Marini, O. Metton, D. Bonnet, D. Sidi, and P. R. Vouhe Common arterial trunk repair: with conduit or without? Eur. J. Cardiothorac. Surg., October 1, 2009; 36(4): 675 - 682. [Abstract] [Full Text] [PDF]

				G. Furlanetto, C. H Passerino, R. Siegel, D. T Chueng, S. Levitsky, and I. S J Casagrande Biointegration and Growth of Porcine Valved Pulmonary Conduits in a Sheep Model Asian Cardiovasc Thorac Ann, August 1, 2009; 17(4): 350 - 356. [Abstract] [Full Text] [PDF]

				J. A. Hawkins, C. T. Sower, L. M. Lambert, P. C. Kouretas, P. T. Burch, A. K. Kaza, M. D. Puchalski, and A. T. Yetman Stentless porcine valves in the right ventricular outflow tract: improved durability? Eur. J. Cardiothorac. Surg., April 1, 2009; 35(4): 600 - 605. [Abstract] [Full Text] [PDF]

				D. Boethig, W.-R. Thies, H. Hecker, and T. Breymann Mid term course after pediatric right ventricular outflow tract reconstruction: a comparison of homografts, porcine xenografts and Contegras Eur. J. Cardiothorac. Surg., January 1, 2005; 27(1): 58 - 66. [Abstract] [Full Text] [PDF]

				Y. Isomatsu, T. Shin'oka, M. Aoki, M. Terada, T. Takeuchi, S. Hoshino, Y. Takanashi, Y. Imai, and H. Kurosawa Establishing right ventricle-pulmonary artery continuity by autologous tissue: an alternative approach for prosthetic conduit repair Ann. Thorac. Surg., July 1, 2004; 78(1): 173 - 180. [Abstract] [Full Text] [PDF]

				J. R. Lee, H. G. Lim, Y. J. Kim, J. R. Rho, E. J. Bae, C. I. Noh, Y. S. Yun, and C. Ahn Repair of transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction Eur. J. Cardiothorac. Surg., May 1, 2004; 25(5): 735 - 741. [Abstract] [Full Text] [PDF]

				Z. M. Hijazi Transcatheter valve replacement: a new era of percutaneous cardiac intervention begins J. Am. Coll. Cardiol., March 17, 2004; 43(6): 1088 - 1089. [Full Text] [PDF]

				D. R. Clarke Presidential address: Value, viability, and valves J. Thorac. Cardiovasc. Surg., July 1, 2002; 124(1): 1 - 6. [Full Text] [PDF]

				B. Aupecle, A. Serraf, E. Belli, S. Mohammadi, F. Lacour-Gayet, P. Fornes, and C. Planche Intermediate follow-up of a composite stentless porcine valved conduit of bovine pericardium in the pulmonary circulation Ann. Thorac. Surg., July 1, 2002; 74(1): 127 - 132. [Abstract] [Full Text] [PDF]

				P. Bonhoeffer, Y. Boudjemline, S. A. Qureshi, J. Le Bidois, L. Iserin, P. Acar, J. Merckx, J. Kachaner, and D. Sidi Percutaneous insertion of the pulmonary valve J. Am. Coll. Cardiol., May 15, 2002; 39(10): 1664 - 1669. [Abstract] [Full Text] [PDF]

				Y. J. Kim, Y. S. Choi, J. R. Lee, and J. R. Rho Ventricular Outflow Tract Reconstruction With Polystan Valved Conduit Asian Cardiovasc Thorac Ann, September 1, 2001; 9(3): 187 - 191. [Abstract] [Full Text] [PDF]

				M.H.D. Danton, D.J. Barron, O. Stumper, J.G. Wright, J. De Giovannni, E.D. Silove, and W.J. Brawn Repair of truncus arteriosus: a considered approach to right ventricular outflow tract reconstruction Eur. J. Cardiothorac. Surg., July 1, 2001; 20(1): 95 - 104. [Abstract] [Full Text] [PDF]

				M. R. Bielefeld, D. A. Bishop, D. N. Campbell, M. B. Mitchell, F. L. Grover, and D. R. Clarke Reoperative homograft right ventricular outflow tract reconstruction Ann. Thorac. Surg., February 1, 2001; 71(2): 482 - 488. [Abstract] [Full Text] [PDF]

				S. Dittrich, V. V. Alexi-Meskishvili, A. C. Yankah, I. Dahnert, R. Meyer, R. Hetzer, and P. E. Lange Comparison of porcine xenografts and homografts for pulmonary valve replacement in children Ann. Thorac. Surg., September 1, 2000; 70(3): 717 - 722. [Abstract] [Full Text] [PDF]

				C. Kreutzer, J. De Vive, G. Oppido, J. Kreutzer, K. Gauvreau, M. Freed, J. E. Mayer Jr, R. Jonas, and P. J. del Nido Twenty-five-year experience with Rastelli repair for transposition of the great arteries J. Thorac. Cardiovasc. Surg., August 1, 2000; 120(2): 211 - 223. [Abstract] [Full Text] [PDF]

				A. J. Schlichter, C. Kreutzer, R. d. C. Mayorquim, J. L. Simon, M. I. Roman, H. Vazquez, E. A. Kreutzer, G. O. Kreutzer, and S. R. A. Jonas Five- to fifteen-year follow-up of fresh autologous pericardial valved conduits J. Thorac. Cardiovasc. Surg., May 1, 2000; 119(5): 869 - 879. [Abstract] [Full Text] [PDF]