HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Gregory A. Thomas Frank A. Baciewicz, Jr Larry W. Stephenson Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thomas, G. A. Articles by Stephenson, L. W. Search for Related Content PubMed PubMed Citation Articles by Thomas, G. A. Articles by Stephenson, L. W.

J Thorac Cardiovasc Surg 1998;116:1029-1042
© 1998 Mosby, Inc.

CARDIOPULMONARY SUPPORT AND PHYSIOLOGY

POWER OUTPUT OF PERICARDIUM-LINED SKELETAL MUSCLE VENTRICLES, LEFT VENTRICULAR APEX TO AORTA CONFIGURATION: UP TO EIGHT MONTHS IN CIRCULATION

Supported by National Institutes of Health grant HL34778.

Read at the Seventy-eighth Annual Meeting of The American Association for Thoracic Surgery, Boston, Mass, May 3-6, 1998.

Received for publication May 7, 1998. Revisions requested June 3, 1998; revisions received July 31, 1998. Accepted for publication Aug 5, 1998. Address for reprints: Frank A. Baciewicz, Jr, MD, Suite 2102 Harper Professional Bldg, 3990 John R St, Detroit, MI 48201-2097.

Objective:The purpose of this experiment was to evaluate the potential for a skeletal muscle ventricle connected to the circulation between the left ventricle and the aorta to provide effective, long-term cardiac assist.
Methods: Skeletal muscle ventricles were constructed from the latissimus muscle in 10 dogs. After conditioning, the skeletal muscle ventricles were connected to the left ventricle and the aorta with 2 valved conduits. The skeletal muscle ventricle was programmed to contract during diastole.
Results: At time of implantation, skeletal muscle ventricles stimulated at 33 Hz and in a 1:2 ratio with the heart significantly decreased left ventricular work by 56% (P < .01) and at 50 Hz by 65% (P < .01). At a 1:2 ratio, the power output of the skeletal muscle ventricles was 59% of left ventricular power output at 33 Hz (P < .01) and 93% at 50 Hz (P < .01). Animals survived 7, 11, 16, 17, 72, 99, 115, 214, and 249 days. Three deaths were directly related to the skeletal muscle ventricle. One animal is alive at 228 days. In the animal that survived 249 days, skeletal muscle ventricle power output at 8 months with a 33 Hz stimulation frequency and a 1:2 contraction ratio was 57% of left ventricular power output and 82% at 50 Hz. At a 1:1 ratio, skeletal muscle ventricle power output was 97% and 173% of the left ventricle at 33 and 50 Hz, respectively.
Conclusions: Left ventricular assist with a skeletal muscle ventricle connected between the left ventricle and the aorta is the most hemodynamically effective configuration we have tested and can maintain significant power output up to 8 months.

This article has been cited by other articles:

				L. W. Stephenson History of Cardiac Surgery Card. Surg. Adult, January 1, 2003; 2(2003): 3 - 29. [Full Text]

				G. A. Thomas and L. W. Stephenson Update 2001: Skeletal muscle ventricles: left ventricular apex to aorta configuration Ann. Thorac. Surg., May 1, 2001; 71(5): 1736 - 1737. [Full Text] [PDF]

				G. A. Thomas, R. L. Hammond, K. Greer, H. Lu, J. C. Jarvis, A. P. Shortland, D. M. Pullan, S. Salmons, and L. W. Stephenson Functional assessment of skeletal muscle ventricles after pumping for up to four years in circulation Ann. Thorac. Surg., October 1, 2000; 70(4): 1281 - 1289. [Abstract] [Full Text] [PDF]

				L. I. Astra and L. W. Stephenson Skeletal Muscle as a Myocardial Substitute Experimental Biology and Medicine, July 1, 2000; 224(3): 133 - 140. [Abstract] [Full Text]