JTCS Speed Up Your Browser
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Koh Takeuchi
Pedro J. del Nido
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takeuchi, K.
Right arrow Articles by McGowan, F. X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takeuchi, K.
Right arrow Articles by McGowan, F. X., Jr

J Thorac Cardiovasc Surg 1999;117:375-382
© 1999 Mosby, Inc.

CARDIOPULMONARY SUPPORT AND PHYSIOLOGY

VESNARINONE AND AMRINONE REDUCE THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME

Koh Takeuchi, MD, Pedro J. del Nido, MD, Andra E. Ibrahim, MD, Hung Cao-Danh, PhD, Ingeborg Friehs, MD, Paul Glynn, PhD, Dimitrios Poutias, BS, Douglas B. Cowan, PhD, Francis X. McGowan, Jr, MD

From the Department of Cardiac Surgery and the Anesthesiology/ Critical Care Medicine Laboratory, Children's Hospital and Harvard Medical School, Boston, Mass.

Supported in part by National Institutes of Health grants HL-52589 (F.X.M.) and HL46207 (P.J.D.).

Read at the Seventy-eighth Annual Meeting of The American Association for Thoracic Surgery, Boston, Mass, May 3-6, 1998.

Received for publication May 8, 1998. Revisions requested July 7, 1998. Revisions received Aug 20, 1998. Accepted for publication Sept 14, 1998. Address for reprints: Francis X. McGowan, Jr, MD, Cardiac Anesthesia Service, Children's Hospital, 300 Longwood Ave, Boston, MA 02115.

Objective: The systemic inflammatory response is an important cause of organ dysfunction. The present study tested the hypothesis that 2 clinically used agents, amrinone and vesnarinone, would decrease inflammation and cardiac dysfunction in a relevant model of systemic inflammatory response activation.
Methods: Rabbits received intravenous endotoxin, alone or in conjunction with amrinone or vesnarinone. Systemic effects were assessed by death, fever, behavior, and acidosis. Measures of inflammatory signaling were (1) plasma tumor necrosis factor-{alpha} and interleukin-1 ß production, (2) lung tissue myeloperoxidase activity, and (3) myocardial inducible nitric oxide synthase activity. Indices of systolic and diastolic myocardial function were measured in Langendorff-perfused hearts.
Results: Vesnarinone, in particular, reduced mortality rates (19% vs 61% for lipopolysaccharide alone, P = .01) and acidosis in lipopolysaccharide-treated rabbits. Both agents markedly reduced systemic tumor necrosis factor and interleukin-1 concentrations, lipopolysaccharide-mediated effects on myocardial systolic and diastolic function and on myocardial inducible nitric oxide synthase activity. Vesnarinone, but not amrinone, (1) decreased fever and lethargy, consistent with decreased central nervous system effects of endotoxin, and (2) decreased lung leukocyte infiltration.
Conclusions: Vesnarinone and amrinone, which are used clinically for their inotropic and vasodilating properties, may be useful to limit inflammatory activation and consequent organ dysfunction. Structure-activity and/or pharmacokinetic between the compounds may be important, particularly in preventing inflamatory signaling within certain tissues.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
B. M. Tsai, M. W. Turrentine, B. C. Sheridan, M. Wang, A. C. Fiore, J. W. Brown, and D. R. Meldrum
Differential Effects of Phosphodiesterase-5 Inhibitors on Hypoxic Pulmonary Vasoconstriction and Pulmonary Artery Cytokine Expression
Ann. Thorac. Surg., January 1, 2006; 81(1): 272 - 278.
[Abstract] [Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
S. G Raja and G. D Dreyfus
Modulation of Systemic Inflammatory Response after Cardiac Surgery
Asian Cardiovasc Thorac Ann, December 1, 2005; 13(4): 382 - 395.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
A. J. Chong, C. R. Hampton, and E. D. Verrier
Microvascular Inflammatory Response in Cardiac Surgery
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 333 - 354.
[Abstract] [PDF]

Home page
 CirculationHome page
N. K. Chanani, D. B. Cowan, K. Takeuchi, D. N. Poutias, L. M. Garcia, P. J. del Nido, and F. X. McGowan Jr
Differential Effects of Amrinone and Milrinone Upon Myocardial Inflammatory Signaling
Circulation, September 24, 2002; 106(12_suppl_1): I-284 - I-289.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
D. Paparella, T.M. Yau, and E. Young
Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update
Eur. J. Cardiothorac. Surg., February 1, 2002; 21(2): 232 - 244.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. K. Manna and B. B. Aggarwal
Vesnarinone Suppresses TNF-Induced Activation of NF-{kappa}B, c-Jun Kinase, and Apoptosis
J. Immunol., June 1, 2000; 164(11): 5815 - 5825.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1999 by The American Association for Thoracic Surgery.