HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Robert D. Lasley Robert M. Mentzer, Jr Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jahania, M. S. Articles by Mentzer, R. M. Search for Related Content PubMed PubMed Citation Articles by Jahania, M. S. Articles by Mentzer, R. M., Jr

J Thorac Cardiovasc Surg 1999;117:810-817
© 1999 Mosby, Inc.

CARDIOPULMONARY SUPPORT AND PHYSIOLOGY

ISCHEMIC PRECONDITIONING DOES NOT ACUTELY IMPROVE LOAD-INSENSITIVE PARAMETERS OF CONTRACTILITY IN IN VIVO STUNNED PORCINE MYOCARDIUM

From the Department of Surgery, University of Kentucky College of Medicine, Lexington, Ky.

Supported by grant HL34579 from The National Heart, Lung, and Blood Institute.

Received for publication Aug 31, 1998. Revisions requested Oct 30, 1998. Revisions received Dec 4, 1998. Accepted for publication Dec 4, 1998. Address for reprints: M. Salik Jahania, MD, Department of Surgery, University of Kentucky College of Medicine, Albert B. Chandler Medical Center, MN 273 B, 800 Rose St, Lexington, KY 40536-0084.

Objective: Ischemic preconditioning has been shown to have no beneficial effect on segment shortening in in vivo regionally stunned myocardium. The purpose of this study was to determine whether ischemic preconditioning improves the recovery of postischemic ventricular function when contractility is assessed by load-insensitive measurements including end-systolic pressure length relations, preload recruitable stroke work, and preload recruitable stroke work area in in vivo regionally stunned porcine myocardium.
Methods: Open chest, pentobarbital-anesthetized pigs were used. Regional ventricular function was monitored by measurements of segment shortening, stroke work, end systolic pressure length relations, preload recruitable stroke work, and preload recruitable stroke work area. The control group was submitted to 15 minutes of left anterior descending coronary artery occlusion and 3 hours of reperfusion. The preconditioned group underwent 2 cycles of 5-minute left anterior descending coronary artery occlusion and 10-minute reperfusion before 15 minutes of occlusion.
Results: There was no infarct in either group. The preconditioning protocol significantly depressed preischemic segment shortening but not regional stroke work. Ischemic preconditioning had no significant beneficial effect on regional stroke work, end-systolic pressure length relations, preload recruitable stroke work, or preload recruitable stroke work area.
Conclusions: These results confirm that ischemic preconditioning does not ameliorate in vivo porcine myocardial stunning and indicate that ischemic preconditioning may have a limited cardioprotective role during cardiac operation.

This article has been cited by other articles:

				R. M. Mentzer Jr, M. S. Jahania, and R. D. Lasley Myocardial Protection Card. Surg. Adult, January 1, 2008; 3(2008): 443 - 464. [Full Text]

				R. M. Stevens, M. Salik Jahania, R. M. Mentzer Jr, and R. D. Lasley Sodium-hydrogen exchange inhibition attenuates in vivo porcine myocardial stunning Ann. Thorac. Surg., February 1, 2004; 77(2): 651 - 657. [Abstract] [Full Text] [PDF]

				J. Vaage Invited commentary Ann. Thorac. Surg., April 1, 2003; 75(4): 1252 - 1252. [Full Text] [PDF]

				R. M. Mentzer Jr., M. S. Jahania, and R. D. Lasley Myocardial Protection Card. Surg. Adult, January 1, 2003; 2(2003): 413 - 438. [Full Text]

				U. Sunderdiek, S. Schmitz-Spanke, B. Korbmacher, E. Gams, and J. D. Schipke Preconditioning: myocardial function and energetics during coronary hypoperfusion and reperfusion Ann. Thorac. Surg., December 1, 2002; 74(6): 2147 - 2155. [Abstract] [Full Text] [PDF]

				D. C. Sigg, J. A. Coles Jr., P. R. Oeltgen, and P. A. Iaizzo Role of delta -opioid receptor agonists on infarct size reduction in swine Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1953 - H1960. [Abstract] [Full Text] [PDF]

				R. Schulz, M. V Cohen, M. Behrends, J. M Downey, and G. Heusch Signal transduction of ischemic preconditioning Cardiovasc Res, November 1, 2001; 52(2): 181 - 198. [Full Text] [PDF]

				U. Sunderdiek, S. Schmitz-Spanke, B. Korbmacher, E. Gams, and J. D. Schipke Left ventricular dysfunction and disturbed O2-utilization in stunned myocardium: influence of ischemic preconditioning Eur. J. Cardiothorac. Surg., October 1, 2001; 20(4): 770 - 776. [Abstract] [Full Text] [PDF]

				Y. Suematsu, T. Ohtsuka, Y. Hirata, K. Maeda, K. Imanaka, and S. Takamoto L-Arginine given after ischaemic preconditioning can enhance cardioprotection in isolated rat hearts Eur. J. Cardiothorac. Surg., June 1, 2001; 19(6): 873 - 879. [Abstract] [Full Text] [PDF]

				A. Efstathiou, S. Seraskeris, C. Papakonstantinou, A. Aidonopoulos, and A. Lazou Differential effect of preconditioning on post-ischaemic myocardial performance in the absence of substantial infarction and in extensively infarcted rat hearts Eur. J. Cardiothorac. Surg., April 1, 2001; 19(4): 493 - 499. [Abstract] [Full Text] [PDF]

				R. D. Lasley, M. S. Jahania, and R. M. Mentzer Jr. Beneficial effects of adenosine A2a agonist CGS-21680 in infarcted and stunned porcine myocardium Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1660 - H1666. [Abstract] [Full Text] [PDF]