JTCS Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Curtis G. Tribble
John A. Kern
Irving L. Kron
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fiser, S. M.
Right arrow Articles by Kron, I. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fiser, S. M.
Right arrow Articles by Kron, I. L.
Related Collections
Right arrow Lung - transplantation

J Thorac Cardiovasc Surg 2001;121:1069-1075
© 2001 The American Association for Thoracic Surgery

General Thoracic Surgery

Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response

Steven M. Fiser, MD, Curtis G. Tribble, MD, FACS, Stewart M. Long, MD, Aditya K. Kaza, MD, Jeffrey T. Cope, MD, Victor E. Laubach, PhD, John A. Kern, MD, Irving L. Kron, MD, FACS

From the Department of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, Charlottesville, Va.

Supported by the National Institutes of Health under R01 grant HL56093-03, National Research Service Award F32 grant HL10248-01, and cooperative agreement U54 HD28934 as part of the Specialized Cooperative Centers Program in Reproduction Research.

Presented at the American College of Surgeons Meeting Surgical Forum, October 22-27, 2000, Chicago, Ill.

Received for publication Sept 13, 2000. Revisions requested Dec 6, 2000; revisions received Dec 12, 2000. Accepted for publication Dec 13, 2000. Address for reprints: Steven M. Fiser, MD, Department of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, PO Box 801359, MR4 Building, Room 3111, Charlottesville, VA 22908 (E-mail: smf9e @virginia.edu).

Objective: Both donor pulmonary macrophages and recipient circulating leukocytes may be involved in reperfusion injury after lung transplantation. By using the macrophage inhibitor gadolinium chloride and leukocyte filters, we attempted to identify the roles of these two populations of cells in lung transplant reperfusion injury.
Methods: With our isolated, ventilated, blood-perfused rabbit lung model, all groups underwent lung harvest followed by 18-hour cold storage and 2-hour blood reperfusion. Measurements of pulmonary artery pressure, lung compliance, and arterial oxygenation were obtained. Group I (n = 8) served as a control. Group II (n = 8) received gadolinium chloride at 14 mg/kg 24 hours before lung harvest. Group III (n = 8) received leukocyte-depleted blood reperfusion by means of a leukocyte filter.
Results: The gadolinium chloride group had significantly improved arterial oxygenation and pulmonary artery pressure measurements compared with control subjects and an improved arterial oxygenation compared with the filter group after 30 minutes of reperfusion. After 120 minutes of reperfusion, however, the filter group had significantly improved arterial oxygenation and pulmonary artery pressure measurements compared with the control group and an improved arterial oxygenation compared with the gadolinium chloride group.
Conclusions: Lung transplant reperfusion injury occurs in two phases. The early phase is mediated by donor pulmonary macrophages and is followed by a late injury induced by recipient circulating leukocytes.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
L. M. Gazoni, C. G. Tribble, M. Q. Zhao, E. B. Unger, R. A. Farrar, P. I. Ellman, L. G. Fernandez, V. E. Laubach, and I. L. Kron
Pulmonary Macrophage Inhibition and Inhaled Nitric Oxide Attenuate Lung Ischemia-Reperfusion Injury
Ann. Thorac. Surg., July 1, 2007; 84(1): 247 - 253.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. K. Sharma, L. G. Fernandez, A. S. Awad, I. L. Kron, and V. E. Laubach
Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-{alpha} during pulmonary ischemia-reperfusion injury
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L105 - L113.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. Pacher, J. S. Beckman, and L. Liaudet
Nitric Oxide and Peroxynitrite in Health and Disease
Physiol Rev, January 1, 2007; 87(1): 315 - 424.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Schmidt, J. Sucke, G. Fuchs-Moll, P. Freitag, M. Hirschburger, A. Kaufmann, H. Garn, W. Padberg, and V. Grau
Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situ
J. Leukoc. Biol., January 1, 2007; 81(1): 186 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Zhao, L. G. Fernandez, A. Doctor, A. K. Sharma, A. Zarbock, C. G. Tribble, I. L. Kron, and V. E. Laubach
Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury
Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L1018 - L1026.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
Y. A. B. Reyes, T. Shimoyama, H. Akamatsu, and M. Sunamori
MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A2 in an isolated rat lung model after 18 h of cold preservation
Eur. J. Cardiothorac. Surg., March 1, 2006; 29(3): 304 - 311.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
H. B. Bittner, M. Richter, T. Kuntze, A. Rahmel, P. Dahlberg, M. Hertz, and F. W. Mohr
Aprotinin decreases reperfusion injury and allograft dysfunction in clinical lung transplantation
Eur. J. Cardiothorac. Surg., February 1, 2006; 29(2): 210 - 215.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. S. Wilkes, T. M. Egan, and H. Y. Reynolds
Lung Transplantation: Opportunities for Research and Clinical Advancement
Am. J. Respir. Crit. Care Med., October 15, 2005; 172(8): 944 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
T. Shimoyama, N. Tabuchi, K. Kojima, H. Akamatsu, H. Arai, H. Tanaka, and M. Sunamori
Aprotinin attenuated ischemia-reperfusion injury in an isolated rat lung model after 18-hours preservation
Eur. J. Cardiothorac. Surg., October 1, 2005; 28(4): 581 - 587.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. B. Reece, P. I. Ellman, T. S. Maxey, I. K. Crosby, P. S. Warren, T. W. Chong, R. D. LeGallo, J. Linden, J. A. Kern, C. G. Tribble, et al.
Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation
J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1137 - 1143.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. B. Reece, D. O. Okonkwo, P. I. Ellman, P. S. Warren, R. L. Smith, A. S. Hawkins, J. Linden, I. L. Kron, C. G. Tribble, and J. A. Kern
The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation
J. Thorac. Cardiovasc. Surg., December 1, 2004; 128(6): 925 - 932.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
B. V. Naidu, S. M. Woolley, A. S. Farivar, R. Thomas, C. H. Fraga, C. H. Goss, and M. S. Mulligan
Early tumor necrosis factor-{alpha} release from the pulmonary macrophage in lung ischemia-reperfusion injury
J. Thorac. Cardiovasc. Surg., May 1, 2004; 127(5): 1502 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. M. Woolley, A. S. Farivar, B. V. Naidu, M. Rosengart, R. Thomas, C. Fraga, and M. S. Mulligan
Endotracheal calcineurin inhibition ameliorates injury in an experimental model of lung ischemia-reperfusion
J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 376 - 384.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. S. Maxey, R. I. Enelow, B. Gaston, I. L. Kron, V. E. Laubach, and A. Doctor
Tumor necrosis factor-{alpha} from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury
J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 541 - 547.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. de Perrot, K. Young, Y. Imai, M. Liu, T. K. Waddell, S. Fischer, L. Zhang, and S. Keshavjee
Recipient T Cells Mediate Reperfusion Injury after Lung Transplantation in the Rat
J. Immunol., November 15, 2003; 171(10): 4995 - 5002.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
B. V. Naidu, B. Krishnadasan, A. S. Farivar, S. M. Woolley, R. Thomas, N. Van Rooijen, E. D. Verrier, and M. S. Mulligan
Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury
J. Thorac. Cardiovasc. Surg., July 1, 2003; 126(1): 200 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. O. Meade, J. T. Granton, A. Matte-Martyn, K. McRae, B. Weaver, P. Cripps, and S. H. Keshavjee
A Randomized Trial of Inhaled Nitric Oxide to Prevent Ischemia-Reperfusion Injury after Lung Transplantation
Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1483 - 1489.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. de Perrot, S. Fischer, M. Liu, Y. Imai, S. Martins, S. Sakiyama, T. Tabata, X.-H. Bai, T. K. Waddell, B. L. Davidson, et al.
Impact of Human Interleukin-10 on Vector-Induced Inflammation and Early Graft Function in Rat Lung Transplantation
Am. J. Respir. Cell Mol. Biol., May 1, 2003; 28(5): 616 - 625.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee
Ischemia-Reperfusion-induced Lung Injury
Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
F. R Rega, E. J Vandezande, N. C Jannis, G. M Verleden, T. E Lerut, and D. E. Van Raemdonck
The role of leukocyte depletion in ex vivo evaluation of pulmonary grafts from (non-)heart-beating donors
Perfusion, January 1, 2003; 18(1_suppl): 13 - 21.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. V. Naidu, B. Krishnadasan, K. Byrne, A. L. Farr, M. Rosengart, E. D. Verrier, and M. S. Mulligan
Regulation of chemokine expression by cyclosporine a in alveolar macrophages exposed to hypoxia and reoxygenation
Ann. Thorac. Surg., September 1, 2002; 74(3): 899 - 905.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
M. Kurusz, J. D Roach Jr, R. A Vertrees, M. K Girouard, and S. D Lick
Leukocyte filtration in lung transplantation
Perfusion, March 1, 2002; 17(2_suppl): 63 - 67.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2001 by The American Association for Thoracic Surgery.