| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 2001;121:1069-1075
© 2001 The American Association for Thoracic Surgery
General Thoracic Surgery |
From the Department of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, Charlottesville, Va.
Supported by the National Institutes of Health under R01 grant HL56093-03, National Research Service Award F32 grant HL10248-01, and cooperative agreement U54 HD28934 as part of the Specialized Cooperative Centers Program in Reproduction Research.
Presented at the American College of Surgeons Meeting Surgical Forum, October 22-27, 2000, Chicago, Ill.
Received for publication Sept 13, 2000. Revisions requested Dec 6, 2000; revisions received Dec 12, 2000. Accepted for publication Dec 13, 2000. Address for reprints: Steven M. Fiser, MD, Department of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, PO Box 801359, MR4 Building, Room 3111, Charlottesville, VA 22908 (E-mail: smf9e @virginia.edu).
Objective: Both donor pulmonary macrophages and recipient circulating leukocytes may be involved in reperfusion injury after lung transplantation. By using the macrophage inhibitor gadolinium chloride and leukocyte filters, we attempted to identify the roles of these two populations of cells in lung transplant reperfusion injury.
Methods: With our isolated, ventilated, blood-perfused rabbit lung model, all groups underwent lung harvest followed by 18-hour cold storage and 2-hour blood reperfusion. Measurements of pulmonary artery pressure, lung compliance, and arterial oxygenation were obtained. Group I (n = 8) served as a control. Group II (n = 8) received gadolinium chloride at 14 mg/kg 24 hours before lung harvest. Group III (n = 8) received leukocyte-depleted blood reperfusion by means of a leukocyte filter.
Results: The gadolinium chloride group had significantly improved arterial oxygenation and pulmonary artery pressure measurements compared with control subjects and an improved arterial oxygenation compared with the filter group after 30 minutes of reperfusion. After 120 minutes of reperfusion, however, the filter group had significantly improved arterial oxygenation and pulmonary artery pressure measurements compared with the control group and an improved arterial oxygenation compared with the gadolinium chloride group.
Conclusions: Lung transplant reperfusion injury occurs in two phases. The early phase is mediated by donor pulmonary macrophages and is followed by a late injury induced by recipient circulating leukocytes.
This article has been cited by other articles:
|
|
 |
|
  Z. Yang, A. K. Sharma, J. Linden, I. L. Kron, and V. E. Laubach CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg., March 1, 2009; 137(3): 695 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yang, A. K. Sharma, M. Marshall, I. L. Kron, and V. E. Laubach NADPH Oxidase in Bone Marrow-Derived Cells Mediates Pulmonary Ischemia-Reperfusion Injury Am. J. Respir. Cell Mol. Biol., March 1, 2009; 40(3): 375 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P. van der Kaaij and A. J.J.C. Bogers Invited Commentary Ann. Thorac. Surg., December 1, 2008; 86(6): 1779 - 1780. [Full Text] [PDF]
|
|
|
|
|
|
L. M. Gazoni, C. G. Tribble, M. Q. Zhao, E. B. Unger, R. A. Farrar, P. I. Ellman, L. G. Fernandez, V. E. Laubach, and I. L. Kron Pulmonary Macrophage Inhibition and Inhaled Nitric Oxide Attenuate Lung Ischemia-Reperfusion Injury Ann. Thorac. Surg., July 1, 2007; 84(1): 247 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Sharma, L. G. Fernandez, A. S. Awad, I. L. Kron, and V. E. Laubach Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-{alpha} during pulmonary ischemia-reperfusion injury Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L105 - L113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pacher, J. S. Beckman, and L. Liaudet Nitric Oxide and Peroxynitrite in Health and Disease Physiol Rev, January 1, 2007; 87(1): 315 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schmidt, J. Sucke, G. Fuchs-Moll, P. Freitag, M. Hirschburger, A. Kaufmann, H. Garn, W. Padberg, and V. Grau Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situ J. Leukoc. Biol., January 1, 2007; 81(1): 186 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhao, L. G. Fernandez, A. Doctor, A. K. Sharma, A. Zarbock, C. G. Tribble, I. L. Kron, and V. E. Laubach Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L1018 - L1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A. B. Reyes, T. Shimoyama, H. Akamatsu, and M. Sunamori MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A2 in an isolated rat lung model after 18 h of cold preservation Eur. J. Cardiothorac. Surg., March 1, 2006; 29(3): 304 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Bittner, M. Richter, T. Kuntze, A. Rahmel, P. Dahlberg, M. Hertz, and F. W. Mohr Aprotinin decreases reperfusion injury and allograft dysfunction in clinical lung transplantation Eur. J. Cardiothorac. Surg., February 1, 2006; 29(2): 210 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Wilkes, T. M. Egan, and H. Y. Reynolds Lung Transplantation: Opportunities for Research and Clinical Advancement Am. J. Respir. Crit. Care Med., October 15, 2005; 172(8): 944 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimoyama, N. Tabuchi, K. Kojima, H. Akamatsu, H. Arai, H. Tanaka, and M. Sunamori Aprotinin attenuated ischemia-reperfusion injury in an isolated rat lung model after 18-hours preservation Eur. J. Cardiothorac. Surg., October 1, 2005; 28(4): 581 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Reece, P. I. Ellman, T. S. Maxey, I. K. Crosby, P. S. Warren, T. W. Chong, R. D. LeGallo, J. Linden, J. A. Kern, C. G. Tribble, et al. Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1137 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Reece, D. O. Okonkwo, P. I. Ellman, P. S. Warren, R. L. Smith, A. S. Hawkins, J. Linden, I. L. Kron, C. G. Tribble, and J. A. Kern The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation J. Thorac. Cardiovasc. Surg., December 1, 2004; 128(6): 925 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. V. Naidu, S. M. Woolley, A. S. Farivar, R. Thomas, C. H. Fraga, C. H. Goss, and M. S. Mulligan Early tumor necrosis factor-{alpha} release from the pulmonary macrophage in lung ischemia-reperfusion injury J. Thorac. Cardiovasc. Surg., May 1, 2004; 127(5): 1502 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Woolley, A. S. Farivar, B. V. Naidu, M. Rosengart, R. Thomas, C. Fraga, and M. S. Mulligan Endotracheal calcineurin inhibition ameliorates injury in an experimental model of lung ischemia-reperfusion J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 376 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Maxey, R. I. Enelow, B. Gaston, I. L. Kron, V. E. Laubach, and A. Doctor Tumor necrosis factor-{alpha} from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Perrot, K. Young, Y. Imai, M. Liu, T. K. Waddell, S. Fischer, L. Zhang, and S. Keshavjee Recipient T Cells Mediate Reperfusion Injury after Lung Transplantation in the Rat J. Immunol., November 15, 2003; 171(10): 4995 - 5002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. V. Naidu, B. Krishnadasan, A. S. Farivar, S. M. Woolley, R. Thomas, N. Van Rooijen, E. D. Verrier, and M. S. Mulligan Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury J. Thorac. Cardiovasc. Surg., July 1, 2003; 126(1): 200 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. O. Meade, J. T. Granton, A. Matte-Martyn, K. McRae, B. Weaver, P. Cripps, and S. H. Keshavjee A Randomized Trial of Inhaled Nitric Oxide to Prevent Ischemia-Reperfusion Injury after Lung Transplantation Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1483 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de Perrot, S. Fischer, M. Liu, Y. Imai, S. Martins, S. Sakiyama, T. Tabata, X.-H. Bai, T. K. Waddell, B. L. Davidson, et al. Impact of Human Interleukin-10 on Vector-Induced Inflammation and Early Graft Function in Rat Lung Transplantation Am. J. Respir. Cell Mol. Biol., May 1, 2003; 28(5): 616 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R Rega, E. J Vandezande, N. C Jannis, G. M Verleden, T. E Lerut, and D. E. Van Raemdonck The role of leukocyte depletion in ex vivo evaluation of pulmonary grafts from (non-)heart-beating donors Perfusion, January 1, 2003; 18(1_suppl): 13 - 21. [Abstract] [PDF]
|
|
|
|
|
|
B. V. Naidu, B. Krishnadasan, K. Byrne, A. L. Farr, M. Rosengart, E. D. Verrier, and M. S. Mulligan Regulation of chemokine expression by cyclosporine a in alveolar macrophages exposed to hypoxia and reoxygenation Ann. Thorac. Surg., September 1, 2002; 74(3): 899 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kurusz, J. D Roach Jr, R. A Vertrees, M. K Girouard, and S. D Lick Leukocyte filtration in lung transplantation Perfusion, March 1, 2002; 17(2_suppl): 63 - 67. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
