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J Thorac Cardiovasc Surg 2001;122:358-364
© 2001 The American Association for Thoracic Surgery

Cardiopulmonary Support and Physiology (CPS)

Endothelin-1 during and after cardiopulmonary bypass: Association to graft sensitivity and postoperative recovery

From the Department of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC.

Supported in part by National Institutes of Health grant HL-45024 (F.G.S.). C.A.W. participated in these studies as a National Medical Fellowships Academic Fellow.

Received for publication April 17, 2000. Revisions requested July 11, 2000; revisions received Dec 4, 2000. Accepted for publication Jan 25, 2001. Address for reprints: Francis G. Spinale, MD, PhD, Medical University of South Carolina, Strom Thurmond Research Building, 114 Doughty St, Suite 625, Charleston, SC 29403.

Abstract

Objective: Our objectives are 2-fold: (1) to serially measure the release of endothelin and graft-conduit endothelin sensitivity during and after coronary artery bypass grafting and (2) to define potential relationships of changes in endothelin levels to perioperative parameters.
Methods: Endothelin plasma content was measured in patients (n = 105) undergoing bypass grafting from select vascular compartments before operations and at specific intervals up to 24 hours postoperatively. Endothelin sensitivity was determined in isolated internal thoracic artery segments.
Results: Systemic arterial and pulmonary arterial endothelin levels were increased by approximately 50% immediately after bypass grafting and increased by another 85% during the first 24 hours postoperatively. Endothelin levels were highest in patients with prolonged ventilatory requirements and extended stays in the intensive care unit (10.2 ± 0.8 vs 13.2 ± 1.1 fmol/mL, P = .02, and 9.8 ± 0.7 vs 13.9 ± 1.2 fmol/mL, P = .01, respectively. Endothelin sensitivity of the internal thoracic artery was increased in patients requiring prolonged vasodilator support with nitroglycerin.
Conclusions: Systemic and pulmonary arterial endothelin levels remained increased for at least 24 hours postoperatively. Prolonged pharmacologic management and increased intensive care unit stay were associated with increased systemic endothelin release and heightened graft-conduit sensitivity to endothelin.

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