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J Thorac Cardiovasc Surg 2001;122:495-500
© 2001 The American Association for Thoracic Surgery

Cardiothoracic Transplantation (TX)

Combined heart-kidney transplantation with single-donor allografts

From the Division of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, Calif.

Received for publication Oct 27, 2000. Accepted for publication March 14, 2001. Address for reprints: Carlos Blanche, MD, Division of Cardiothoracic Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Suite 6215, Los Angeles, CA 90048 (E-mail: Carlos.Blanche.{at}cshs.org).

Abstract

Objectives: Combined heart-kidney transplantation with allografts from the same donor has been long proved to be a feasible approach for selected patients with coexisting end-stage cardiomyopathy and renal disease. The purpose of this retrospective study is to analyze our long-term results and compare these results with heart-only transplantation over a 7-year period.
Methods: Between June 1992 and April 1999, 10 patients underwent combined heart-kidney transplantation at Cedars-Sinai Medical Center. They were all men from 44 to 70 years old (mean age, 59 ± 8.3 years) who had a mean left ventricular ejection fraction of 19.4% ± 5.0% (range, 9%-25%) and a mean creatinine clearance of 25.4 mL/min (range, 10-39 mL/min). Four patients underwent pretransplantation dialysis.
Results: There was no operative mortality. The actuarial survival at 1, 2, and 5 years was 100%, 88% ± 11.7%, and 55% ± 20.1%, respectively. By comparison, the operative mortality of 169 patients who underwent heart-only transplantation during the same time interval was 2.4%, with an actuarial survival at 1, 2, and 5 years of 92% ± 2.1%, 84% ± 2.8%, and 71% ± 3.9%, respectively (P = .37). Eight patients showed no evidence of significant (1B) cardiac allograft rejection postoperatively, and the actuarial freedom from rejection at 30 days, 1 year, and 2 years was 90% ± 9%, 80% ± 13%, and 80% ± 13%, respectively. Renal allograft survival was 90% at 1 and 2 years.
Conclusions: Combined heart-kidney transplantation yields satisfactory long-term results similar to those for heart-only transplantation, with a low incidence of cardiac allograft rejection and renal allograft survival when both allografts are from the same donor. This approach effectively expands the selection criteria for heart-only and kidney-only transplantation in potential candidates with coexisting end-stage cardiac and renal disease.

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