HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Pier Luigi Filosso Giovanni Donati Caterina Casadio Enrico Ruffini Giuliano Maggi Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Filosso, P. L. Articles by Maggi, G. Search for Related Content PubMed PubMed Citation Articles by Filosso, P. L. Articles by Maggi, G. Related Collections Trachea and bronchi

J Thorac Cardiovasc Surg 2002;123:303-309
© 2002 The American Association for Thoracic Surgery

General Thoracic Surgery (GTS)

Bronchial carcinoid tumors: Surgical management and long-term outcome

From the Department of Thoracic Surgery, University of Torino, San Giovanni Battista Hospital, Torino, Italy.

Received for publication May 22, 2001. Revisions requested July 3, 2001; revisions received July 23, 2001. Accepted for publication Aug 30, 2001. Address for reprints: Pier Luigi Filosso, MD, Department of Thoracic Surgery, University of Torino, San Giovanni Battista Hospital, via Genova, 3, 101216, Torino, Italy (E-mail: pierluigifilosso{at}tiscalinet.it).

Objective: We sought to determine the variables influencing long-term survival of patients treated for bronchial carcinoid tumors.
Methods: A retrospective, mono-institutional review of patients subjected to surgical treatment since 1977 was conducted.
Results: Over 22 years, 126 patients with a final histologic diagnosis of bronchial carcinoid tumors were assessed for surgery. The group comprised 72 men (57%) and 54 women (43%) with a mean age at presentation of 47 ± 16 years (range 11-77 years). Symptoms were present in 65 (53%) patients. Operations included lobectomy or bilobectomy in 88 (with 4 bronchoplastic procedures), pneumonectomy in 15, segmentectomy in 3, wedge resection in 16, and bronchial sleeve resection in 3 patients. One patient (0.7%) died in the perioperative period. Eighty-two patients (65%) had typical and 44 (35%) had atypical carcinoid tumors. Postoperative staging was complete for 113 of 126 patients (13 patients did not undergo lymphadenectomy): 90 patients had stage I disease, 6 had stage II, 15 had stage III, and 2 had stage IV disease. A typical subtype was stage I in 70 and more advanced (II-IV) in 5, whereas an atypical subtype was stage I in 20 and more advanced in 18 (P < .05). Mean follow-up was 99 ± 73 months (range 6-282 months) during which 19 (15%) patients died (12 of recurrent disease). Recurrent tumor developed in 4 (5.5%) of 72 patients affected by typical subtypes and 8 (19.5%) of 41 by atypical subtypes with complete follow-up. Overall survival at 15 years was 74%; survival related to histologic type and nodal status at 15 years was significant (P < .05).
Conclusions: Biologic behavior and prognosis for bronchial carcinoid tumors are better than for other lung cancers. Surgical treatment requires radical excision and lymph node sampling. Survival and long-term outcome are significantly related to the histologic type, nodal status, and pathologic stage.

This article has been cited by other articles:

				H. A.P. Brokx, E. K. Risse, M. A. Paul, K. Grunberg, R. P. Golding, P. W.A. Kunst, J.-P. Eerenberg, J. C. van Mourik, P. E. Postmus, W. J. Mooi, et al. Initial bronchoscopic treatment for patients with intraluminal bronchial carcinoids J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 973 - 978. [Abstract] [Full Text] [PDF]

				A. P. Townshend, B. Lakshminarayanan, A. E. M. Ucar, Z. R. Chaudry, and J. P. Duffy Rare Pleural Recurrence of Typical Pulmonary Carcinoid Tumor 30 Years After Lobectomy Ann. Thorac. Surg., April 1, 2007; 83(4): 1523 - 1524. [Abstract] [Full Text] [PDF]

				F. Rea, G. Rizzardi, A. Zuin, G. Marulli, S. Nicotra, R. Bulf, M. Schiavon, and F. Sartori Outcome and surgical strategy in bronchial carcinoid tumors: single institution experience with 252 patients Eur. J. Cardiothorac. Surg., February 1, 2007; 31(2): 186 - 191. [Abstract] [Full Text] [PDF]

				M. Garcia-Yuste, J. M. Matilla, A. Cueto, J. M. R. Paniagua, G. Ramos, M. A. Canizares, I. Muguruza, and Members of the Spanish Multi-centric Study of Neur Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung Eur. J. Cardiothorac. Surg., February 1, 2007; 31(2): 192 - 197. [Abstract] [Full Text] [PDF]

				L. Bertoletti, R. Elleuch, D. Kaczmarek, R. Jean-Francois, and J. M. Vergnon Bronchoscopic cryotherapy treatment of isolated endoluminal typical carcinoid tumor. Chest, November 1, 2006; 130(5): 1405 - 1411. [Abstract] [Full Text] [PDF]

				J. Lemaitre, Z. Mansour, E. A. Kochetkova, C. Koriche, X. Ducrocq, J.-M. Wihlm, E. Quoix, and G. Massard Bronchoplastic lobectomy: do early results depend on the underlying pathology? A comparison between typical carcinoids and primary lung cancer. Eur. J. Cardiothorac. Surg., July 1, 2006; 30(1): 168 - 171. [Abstract] [Full Text] [PDF]

				Two-staged treatment of bronchial carcinoid without pulmonary parenchymal resection. J. Thorac. Cardiovasc. Surg., March 1, 2006; 131(3): 753 - 754.

				T. C. Mineo, G. Guggino, D. Mineo, G. Vanni, and V. Ambrogi Relevance of Lymph Node Micrometastases in Radically Resected Endobronchial Carcinoid Tumors Ann. Thorac. Surg., August 1, 2005; 80(2): 428 - 432. [Abstract] [Full Text] [PDF]

				J K Ramage, A H G Davies, J Ardill, N Bax, M Caplin, A Grossman, R Hawkins, A M McNicol, N Reed, R Sutton, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours Gut, June 1, 2005; 54(suppl_4): iv1 - iv16. [Full Text] [PDF]

				P. L. Filosso, A. Arslanian, N. Palestini, A. Farnetti, M. Papotti, M. Bongiovanni, R. Giobbe, and E. Ruffini Thyroid metastasis after resection of atypical bronchial carcinoid J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1840 - 1843. [Full Text] [PDF]

				G. Cardillo, F. Sera, M. Di Martino, P. Graziano, R. Giunti, L. Carbone, F. Facciolo, and M. Martelli Bronchial carcinoid tumors: nodal status and long-term survival after resection Ann. Thorac. Surg., May 1, 2004; 77(5): 1781 - 1785. [Abstract] [Full Text] [PDF]

				P. L. Filosso, G. M. Actis Dato, E. Ruffini, S. Bretti, F. Ozzello, and M. Mancuso Multidisciplinary treatment of advanced thymic neuroendocrine carcinoma (carcinoid): Report of a successful case and review of the literature J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1215 - 1219. [Full Text] [PDF]

				R. Hage, A. B. de la Riviere, C.A. Seldenrijk, and J.M. M. van den Bosch Update in Pulmonary Carcinoid Tumors: A Review Article Ann. Surg. Oncol., July 1, 2003; 10(6): 697 - 704. [Abstract] [Full Text] [PDF]

				P. L. Filosso and E. Ruffini Synchronous bilateral typical carcinoid of the lung Eur. J. Cardiothorac. Surg., July 1, 2003; 24(1): 174 - 174. [Full Text] [PDF]

				P. L. Filosso, G. Donati, O. Rena, and A. Oliaro Acromegaly as Manifestation of a Bronchial Carcinoid Tumour Asian Cardiovasc Thorac Ann, June 1, 2003; 11(2): 189 - 189. [Full Text] [PDF]

				P. L. Filosso, O. Rena, E. Ruffini, A. Oliaro, and L. H. Harrison Intraoperative OctreoScan and Management of Bronchial Carcinoid Chest, October 1, 2002; 122(4): 1493 - 1494. [Full Text] [PDF]