JTCS Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alcaraz, A. J.
Right arrow Articles by Alvarez-Mon, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alcaraz, A. J.
Right arrow Articles by Alvarez-Mon, M.
Related Collections
Right arrow Congenital - cyanotic
Right arrow Extracorporeal circulation

J Thorac Cardiovasc Surg 2002;123:451-458
© 2002 The American Association for Thoracic Surgery

Surgery for Congenital Heart Disease (CHD)

Newborn patients exhibit an unusual pattern of interleukin 10 and interferon {gamma} serum levels in response to cardiac surgery

A. J. Alcaraz, MDa*, L. Sancho, MD, PhDa*, L. Manzano, MD, PhDb,c, F. Esquivel, PhDc, A. Carrillo, MD, PhDa, A. Prieto, PhDc, E. D. Bernstein, MD, PhDc, M. Alvarez-Mon, MD, PhDc,d

From the Department of Pediatrics and Pediatric Surgery, Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Marañóna Service of Medicine/ Clinical Immunology and Oncology, Hospital Universitario Príncipe de Asturias, University of Alcalá, Alcalá de Henaresd Service of Internal Medicine, Hospital Universitario Ramón y Cajal, University of Alcaláb and Laboratory of Clinical Immunology, Department of Medicine, University of Alcalá, Alcalá de Henares,c Madrid, Spain.

This work was partially supported by FIS, CICYT, and FEDER-SALUD.

Received for publication Feb 14, 2001; revisions requested March 21, 2001; revisions received Aug 1, 2001; accepted for publication Aug 31, 2001. Address for reprints: M. Alvarez-Mon, MD, PhD, Departamento de Medicina, Universidad de Alcalá, Alcalá de Henares, 18.871, Madrid, Spain (E-mail: mams{at}tsai.es

Objective: The aim of this study was to determine the clinical significance of serum levels of interleukin 10 and interferon {gamma} in pediatric patients undergoing cardiopulmonary bypass.
Methods: We divided the patients into 2 groups: 8 neonates and 19 nonnewborn children. Interleukin 10 and interferon {gamma} serum levels were quantified before sternotomy, at admission to the pediatric intensive care unit (30 minutes postoperatively), 24 hours after the onset of the operation, and 3 days after the operation.
Results: Newborn patients displayed significantly greater amounts of serum interleukin 10 than older children, not only in regard to the peak level achieved but also at every postoperative time point analyzed. In contrast, no significant changes in interferon {gamma} serum levels were observed in neonates at any time point, whereas nonnewborn pediatric patients showed a significant increase in interferon {gamma} serum concentrations immediately after the operation. This unusual pattern of cytokine response in newborn patients was not associated with modifications in cortisol serum levels. Furthermore, although neonates had significantly different surgical and clinical variables than did the nonnewborn pediatric patients, the variation in interleukin 10 production in neonates could not be accounted for by differences in the magnitude of surgical injury. In the group of neonates, there were significant positive correlations between peak interleukin 10 serum levels and both partial pressure of arterial oxygen/fraction of inspired oxygen ratio and postoperative body weight gain.
Conclusions: Newborn patients undergoing cardiopulmonary bypass exhibit a distinctive biologic response pattern characterized by high levels of serum interleukin 10 without changes in serum interferon {gamma}. This cytokine imbalance could have potential clinical implications.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
M. Caputo, S. Bays, C. A. Rogers, A. Pawade, A. J. Parry, S. Suleiman, and G. D. Angelini
Randomized Comparison Between Normothermic and Hypothermic Cardiopulmonary Bypass in Pediatric Open-Heart Surgery
Ann. Thorac. Surg., September 1, 2005; 80(3): 982 - 988.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Hasegawa, M. Yamaguchi, N. Yoshimura, and Y. Okita
The dependence of myocardial damage on age and ischemic time in pediatric cardiac surgery
J. Thorac. Cardiovasc. Surg., January 1, 2005; 129(1): 192 - 198.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2002 by The American Association for Thoracic Surgery.