HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, Y.-C. Articles by Chang, Y.-L. Search for Related Content PubMed PubMed Citation Articles by Lee, Y.-C. Articles by Chang, Y.-L. Related Collections Lung - cancer

J Thorac Cardiovasc Surg 2002;123:502-507
© 2002 The American Association for Thoracic Surgery

General Thoraic Surgery (GTS)

The significance of E-cadherin and -, ß-, and -catenin expression in surgically treated non–small cell lung cancers of 3 cm or less in size

From the Departments of Surgery^a and Pathology,^b National Taiwan University Hospital, Taipei, Taiwan.

Supported by research grant NSC 88-2314-B-002-322 from the National Science Council, Republic of China.

Received for publication April 16, 2001; revisions requested June 3, 2001; revisions received July 3, 2001. accepted for publication Aug 6, 2001. Address for reprints: Yih-Leong Chang, MD, 6F-1, 99, Section 3, Roosevelt Rd, Taipei 106, Taiwan (E-mail: damu{at}ha.mc.ntu.edu.tw).

Objectives: Expression of the cell-cell adhesion molecules E-cadherin and -, ß-, and -catenin seems closely related to tumor invasiveness. The relationship between the expression and clinicopathologic characteristics in surgically resected non–small cell lung cancers of 3 cm or less in size was studied. The relationship to patient survival was analyzed.
Methods: A total of 115 patients with surgically resected lung cancers of 3 cm or less in size were enrolled in this study. Expression of E-cadherin and -, ß-, and -catenin was immunohistochemically measured. The ² test was used to correlate this expression with clinicopathologic parameters. Their influence on patient survival was evaluated with the Cox proportional hazards model.
Results: There was a positive correlation between E-cadherin and catenin expression in lung cancers. In general, E-cadherin and catenin expression were greater in tumors that were either bronchioloalveolar carcinomas or adenocarcinomas, well differentiated, early stage, peripheral, and without vascular or pleural invasion. By using multicovariate analysis of patient survival, only early-stage and peripheral tumors were significantly favorable prognostic factors. Further analysis of the group of patients with early-stage disease showed that higher -, ß-, or -catenin expression was a favorable prognostic indicator.
Conclusion: Expression of -, ß-, or -catenin can be used as a prognostic indicator in patients with surgically resected stage I non–small cell lung cancers of 3 cm or less in size.

This article has been cited by other articles:

				C-Q Zhu, W Shih, C-H Ling, and M-S Tsao Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation. J. Clin. Pathol., August 1, 2006; 59(8): 790 - 800. [Abstract] [Full Text] [PDF]

				K A Voutilainen, M A Anttila, S M Sillanpaa, K M Ropponen, S V Saarikoski, M T Juhola, and V-M Kosma Prognostic significance of E-cadherin-catenin complex in epithelial ovarian cancer J. Clin. Pathol., May 1, 2006; 59(5): 460 - 467. [Abstract] [Full Text] [PDF]