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Yoshio Kosakai
Yoshikado Sasako
Toshikatsu Yagihara
Soichiro Kitamura
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Right arrow Electrophysiology - arrhythmias
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J Thorac Cardiovasc Surg 2002;124:575-583
© 2002 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease (ACD)

Impact of Cox maze procedure on outcome in patients with atrial fibrillation and mitral valve disease

Ko Bando, MDa, Junjiro Kobayashi, MDa, Yoshio Kosakai, MDb, Mitsuhiro Hirata, MDa, Yoshikado Sasako, MDa, Satoshi Nakatani, MDc, Toshikatsu Yagihara, MDa, Soichiro Kitamura, MDa

From the Departments of Cardiovascular Surgerya and Cardiology,c National Cardiovascular Center, Osaka, and Takarazuka Municipal Hospital,b Takarazuka, Japan.

Read at the Eighty-first Annual Meeting of The American Association for Thoracic Surgery, San Diego, Calif, May 6-9, 2001.

Received for publication May 15, 2001. Revisions requested July 27, 2001; revisions received Dec 20, 2001. Accepted for publication Dec 27, 2001. Address for reprints: Ko Bando, MD, Department of Cardiovascular Surgery, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita, Osaka, 565-8565, Japan (E-mail: kobando{at}hosp.ncvc.go.jp).

Objective: We sought to determine whether the Cox maze procedure provides additional benefit to patients with atrial fibrillation undergoing mitral valve operations.
Methods: Between May 1992 and August 2000, we performed 258 Cox maze procedures with mitral valve replacement (n = 147) or mitral valve repair (n = 111). We compared the outcomes of these patients with those of 61 control patients with preoperative atrial fibrillation who underwent mitral valve replacement alone during the same interval. The three cohorts were similar in age, sex, and proportion of patients in preoperative New York Heart Association functional class 3 or 4.
Results: Although 5-year survivals were similar among the groups (94% for mitral valve replacement alone, 95% for mitral valve replacement plus maze, and 97% for mitral valve repair plus maze), freedoms from atrial fibrillation at 5 years were significantly higher in the mitral valve replacement plus maze group (78%) and the mitral valve repair plus maze group (81%) than in the mitral valve replacement group (6%, P < .0001). Freedoms from stroke at 5 years were 97% for the mitral valve replacement plus maze group, 97% for the mitral valve repair plus maze group, and only 79% for mitral valve replacement group (P < .0001). Multivariable analysis with Cox hazard model revealed that the most significant risk factor for late stroke was the omission of the Cox maze procedure (P = .003).
Conclusions: The addition of the Cox maze procedure to mitral valve repair and replacement was safe and effective for selected patients. Elimination of atrial fibrillation significantly decreased the incidence of late stroke.




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